Double(2-ethyl -3-hydroxyl-4-pyranone)copper(II)complex and its uses in treating diabetes

A technology of complexes and pyrone, which is applied in copper organic compounds, drug combinations, metabolic diseases, etc., can solve the problems of unsatisfactory hypoglycemic activity, low bioavailability, poor fat solubility, etc., and achieve good development and application prospects, Good fat solubility, lowering blood sugar effect

Inactive Publication Date: 2006-02-15
KUNMING MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At present, the copper compound for lowering blood sugar researched and reported at home and abroad is mainly CuSO 4 , copper salicylate Cu (salicylate) 2 , copper gluconate, Cu(gluconate) 2 , copper maltolate Cu (maltolate) 2 , but their poor fat solubility leads to low bioavailability and unsatisfactory hypoglycemic activity [SE Gandy, MG Buse. Diabetologia, 1983, 24, 437] [KH. Thompson, JH McNeil, COrvig. J Inorg Chem, 2004, 98, 683-690]

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  • Double(2-ethyl -3-hydroxyl-4-pyranone)copper(II)complex and its uses in treating diabetes
  • Double(2-ethyl -3-hydroxyl-4-pyranone)copper(II)complex and its uses in treating diabetes

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Embodiment Construction

[0014] (1) Preparation of the compound of the present invention

[0015] Take 5.3g of CuSO 4 5H 2 O, dissolve in 50ml of water, add 50ml, 5.9g of 2-ethyl-3-hydroxy-4-pyrone aqueous solution, adjust the pH to 7.0 with 0.1mol / L NaOH, stir and react for 3 hours, and precipitate green bis(2-ethyl Base-3-hydroxy-4-pyrone) copper(II), collected by filtration, washed with water and ethanol, dried under vacuum at 60-70°C for 4 hours, and then chemically recrystallized in water to obtain 6.5g of pure product, Yield 91%.

[0016] Take 5g of 2-ethyl-3-hydroxyl-4-pyrone, dissolve it in 50ml of water, add an equimolar amount of NaHCO 3 (3.0g) to obtain 2-ethyl-3-hydroxyl-4-pyrone sodium salt, then add CuCl 2 2H 2 O solution (3.1g), stirring and reacting for 3 hours, precipitated green bis(2-ethyl-3-hydroxy-4-pyrone)copper(II), collected by filtration, washed with water and ethanol, and then in 60-70 It was dried under vacuum at °C for 4 hours, and then chemi...

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Abstract

Disclosed is a bis(2-ethyl-3hydroxy-4-pyranone) copper(II) complex and its use in treating diabetes, which relates to heterocyclic compound having oxygen atoms, especially a copper central ionic 2-ethyl-3-hydroxy-4-pyranone chelate and its use. The copper complex has a molecular formula of C14H14CuO6, and a formula weight of FW=341.5. The compound can be made into oral administration medicines against diabetes.

Description

Technical field [0001] The invention relates to heterocyclic compounds containing oxygen atoms, in particular to 2-ethyl-3-hydroxyl-4-pyrone chelates with copper as the central ion and applications thereof. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia caused by insulin secretion defect and its biological action disorder, which can lead to a series of complications and endanger human health. Modern research shows that Cu is an essential trace element for the human body. It is the active center of many redox proteases and plays an important role in the metabolism of glucose [Edited by Yang Kedi. Trace Elements and Health. Science Press. First Edition. 2003, p91-106]. Epidemiological surveys have shown that there is copper deficiency and deficiency in diabetic patients, and copper-containing compounds can make animal models of diabetes show the activity of lowering blood sugar and i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61K31/555A61P3/10
Inventor 李玲谌喜珠刘伟平牛艳芬陈植和王玉天张力
Owner KUNMING MEDICAL UNIVERSITY
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