Cobalt-base alloy, as well as thermal processing and thermal treatment methods and application thereof

A heat treatment method and technology of cobalt-based alloy, applied in the field of medical materials, can solve the problem of in-stent restenosis that cannot be effectively suppressed, and achieve the effects of solving in-stent restenosis, reducing or inhibiting in-stent restenosis, and reducing the formation of thrombus.

Active Publication Date: 2015-03-25
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above problems, the present invention proposes a cobalt-based alloy and its thermal processing, heat treatment

Method used

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  • Cobalt-base alloy, as well as thermal processing and thermal treatment methods and application thereof
  • Cobalt-base alloy, as well as thermal processing and thermal treatment methods and application thereof
  • Cobalt-base alloy, as well as thermal processing and thermal treatment methods and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The content is 20.26 (weight) % of Cr, W: 15.15 (weight) %; Ni: 10.18 (weight) %; Fe: 1.63 %; C: 0.08 (weight) %; Si: 0.58 (weight) %; Mn: 1.15(weight)%; Cu: 4.61(weight)%; the rest is cobalt-based alloy of Co and unavoidable impurities after hot working, specifically:

[0060] Homogenize the cobalt-based alloy at 1200-1250°C for 2-4 hours until the elements in the cobalt-based alloy are fully homogenized;

[0061] The cobalt-based alloy is billet-forged and multi-fired forged into rods and / or blooms, and the final forging temperature is not lower than 1000°C.

[0062] After thermal processing and then heat treatment, specifically:

[0063] Solid solution treatment of the cobalt-based alloy at 1100-1200°C for 1-2 hours until the copper element in the cobalt-based alloy is fully dissolved in the matrix;

[0064] Heat the cobalt-based alloy at 700°C for 2-6 hours until the supersaturated copper is precipitated and a certain amount of copper-rich phase is formed;

[006...

Embodiment 2

[0068] Repeat embodiment 1, following difference is arranged: content is that Cr is 19.87 (weight) %, W: 14.94 (weight) %; Ni: 9.54 (weight) %; Fe: 2.03 (weight) %; C: 0.03 (weight) % ) %; Si: 0.51 (weight) %; Mn: 0.98 (weight) %; Cu: 5.01 (weight) %; the rest is Co and unavoidable impurities Cobalt-based alloy after hot working and heat treatment. See Table 1 for the composition content data of the cobalt-based alloy in Example 2 above, and see Table 2 for the cobalt-based alloy after thermal processing and heat treatment.

Embodiment 3

[0070] Repeat embodiment 1, following difference is arranged: content is that Cr is 19.43 (weight) %, W: 15.59 (weight) %; Ni: 10.90 (weight) %; Fe: 1.98 (weight) %; C: 0.05 (weight) % ) %; Si: 0.80 (weight) %; Mn: 1.85 (weight) %; Cu: 5.45 (weight) %; the rest is Co and unavoidable impurities of cobalt-based alloy after hot working and heat treatment. See Table 1 for the composition content data of the cobalt-based alloy in Example 3, and see Table 2 for the cobalt-based alloy after thermal processing and heat treatment.

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Abstract

The invention provides a cobalt-base alloy. The cobalt-base alloy comprises a Cu element, and the content of the Cu element is 4.5-5.5 percent by weight. The invention further provides a thermal processing method and a thermal treatment method of the cobalt-base alloy, as well as an application of the cobalt-base alloy as a coronary stent. The cobalt-base alloy can be used for persistently generating trace copper in the cardiovascular system, and is capable of inhibiting hyperplasia, migration and degeneration of artery smooth muscles caused after the coronary stent is implanted and effectively reducing formation of thrombus, so that the function of reducing or inhibiting in-stent restenosis caused after the coronary stent is implanted is realized.

Description

technical field [0001] The invention relates to medical materials, in particular to a cobalt-based alloy and its thermal processing, heat treatment method and application. Background technique [0002] Heart disease is one of the primary causes of human health threats, and now about 15 million patients with coronary heart disease worldwide need advanced PTCA (percutaneous transluminal coronary angioplasty, percutaneous coronary angioplasty). PTCA has the advantages of minimal trauma, high efficiency and easy repeatability, so it has become a rapidly developing new method for the treatment of coronary heart disease caused by cardiovascular stenosis. Finely shaped coronary stents are used in PTCA, which are currently mainly processed from medical metal materials such as L605 cobalt-based alloy and 316L stainless steel. [0003] However, a large number of clinical observations show that a certain degree of ISR (in-stent restenosis, in-stent restenosis) occurs after PTCA, espec...

Claims

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Application Information

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IPC IPC(8): C22C19/07C22F1/10A61L27/04
Inventor 任玲杨柯张书源孙子晴杨春光
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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