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Fingerprint detection method for antitumor traditional Chinese medicine composition

A technology of fingerprint spectrum and detection method, which is applied in the field of fingerprint spectrum detection of traditional Chinese medicine compositions, can solve the problems such as the inability to comprehensively and objectively detect and evaluate the quality of Tianfoshen oral liquid.

Active Publication Date: 2015-03-25
常熟雷允上制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, Acanthopanax ovalifolia, kiwi fruit root, and sea buckthorn fruit are extracted by water extraction process, and American ginseng, asparagus, and soil Fritillaria are extracted by alcohol extraction process. The polarity of the compounds contained in the total extract covers the range of strong polarity and medium polarity. The detection methods of the prior art cannot comprehensively and objectively detect and evaluate the quality of Tianfoshen Oral Liquid

Method used

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  • Fingerprint detection method for antitumor traditional Chinese medicine composition
  • Fingerprint detection method for antitumor traditional Chinese medicine composition
  • Fingerprint detection method for antitumor traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] 1. A fingerprint detection method of an anti-tumor Chinese medicinal composition, in parts by weight, the Chinese medicinal composition is composed of 50 parts of American ginseng, 0.25 part of toad venom, 167 parts of Asparagus, 200 parts of Fritillaria, and oval leaf. 599 parts of Wujia, 1,000 parts of kiwi fruit root, 333 parts of sea buckthorn fruit, and 167 parts of bergamot were prepared into oral liquid preparations. The fingerprint detection method includes the following steps:

[0117] (1) Preparation of the test solution: take the traditional Chinese medicine composition and process it by an appropriate method to make the test solution;

[0118] (2) Determination of the reference fingerprint of this product by high performance liquid chromatography: take more than 10 batches of Chinese medicine composition test samples and inject them under appropriate chromatographic conditions, measure the fingerprints of each batch of test samples, and use these fingerprints...

Embodiment 2

[0130] A fingerprint detection method for an anti-tumor traditional Chinese medicine composition, calculated in parts by weight, the traditional Chinese medicine composition is composed of 50 parts of American ginseng, 0.25 parts of toad venom, 167 parts of Asparagus, 200 parts of Fritillaria, and Ovii 599 parts, 1000 parts of kiwi fruit roots, 333 parts of sea buckthorn fruit, and 167 parts of bergamot were prepared into oral liquid preparations. The fingerprint detection method includes the following steps:

[0131] (1) Preparation of the test solution: take the traditional Chinese medicine composition and process it by an appropriate method to make the test solution;

[0132] (2) Determination of the reference fingerprint of this product by high performance liquid chromatography: take more than 10 batches of Chinese medicine composition test samples and inject them under appropriate chromatographic conditions, measure the fingerprints of each batch of test samples, and use t...

Embodiment 3

[0145] A fingerprint detection method for an anti-tumor traditional Chinese medicine composition, calculated in parts by weight, the traditional Chinese medicine composition is composed of 60 parts of American ginseng, 0.30 parts of toad venom, 180 parts of Asparagus, 210 parts of Fritillaria, and Ovale vulgaris 620 parts, 1100 parts of kiwi fruit roots, 340 parts of sea buckthorn fruit, and 210 parts of bergamot were prepared into oral liquid preparations. The fingerprint detection method includes the following steps:

[0146] (1) Preparation of the test solution: take the traditional Chinese medicine composition and process it by an appropriate method to make the test solution;

[0147] (2) Determination of the reference fingerprint of this product by high performance liquid chromatography: take more than 10 batches of Chinese medicine composition test samples and inject them under appropriate chromatographic conditions, measure the fingerprints of each batch of test samples,...

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Abstract

The invention discloses a fingerprint detection method for an antitumor traditional Chinese medicine composition. The composition is prepared from American ginseng, venenum bufonis, asparagus cochinchinensis, rhizoma bolbostemmae, acanthopanax obovatus hoo, Chinese actinidia root, fructus hippophae and fingered citron as crude drugs. Multiple experiments prove that the quality of the composition can be comprehensively, objectively and accurately detected and evaluated by the fingerprint detection method disclosed by the invention; and the clinical curative effect is ensured.

Description

technical field [0001] The invention relates to a fingerprint detection method of a traditional Chinese medicine composition, in particular to a fingerprint detection method of a traditional Chinese medicine composition with antitumor effect. Background technique [0002] Tianfoshen oral liquid is a pure natural traditional Chinese medicine preparation refined by modern advanced technology. It is produced by Changshu Leiyunshang Pharmaceutical Co., Ltd. It has the functions of nourishing yin and nourishing qi, detoxifying and dispersing knots, and it can be used in combination with anti-tumor chemicals. , for non-small cell lung cancer is Qi and Yin deficiency syndrome, can reduce chemotherapy-induced nausea, vomiting, constipation, hair loss and other phenomena, widely used clinically, the effect is accurate and reliable. Among them, Tianfoshen oral liquid is composed of 8 medicinal materials: American ginseng, toad flakes, asparagus, soil fritillary, obovate leaf, kiwi fru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 顾治平阙瑞艳王恒斌陈力建张礼学
Owner 常熟雷允上制药有限公司
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