Application of dermastin a in the preparation of preparations for suppressing immune rejection of organ transplantation

A technology of immune rejection and dermatocin, applied in medical preparations containing active ingredients, gene therapy, peptide/protein components, etc., can solve the problem of low long-term survival rate, achieve the goal of improving survival rate and inhibiting immune rejection Effect
CN104474532BInactive Publication Date: 2016-11-16XUZHOU MEDICAL COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XUZHOU MEDICAL COLLEGE
Publication Date
2016-11-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an application of hypodermin A in preparation of a preparation for inhibiting immunological rejection in organ transplantation. According to the invention, an HA transgenetic mouse is prepared and the survival rate of the skin of the HA transgenetic mouse is remarkably higher than that of the skin of a mild mouse by virtue of allogeneic transplantation of the skin of the mouse. The preparation disclosed by the invention can be used for inhibiting immunological rejection in organ transplantation and improving the survival rate of organ transplantation, thereby providing an effective method for treating chronic end-stage diseases of organs such as liver, kidney, heart and the like.
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Description

technical field

[0001] The invention belongs to the field of organ transplant medicines, in particular to a new application of dermatoxin A (HyderminA, HA), which can reduce organ transplant rejection and provide a new method for allogeneic organ transplantation. Background technique

[0002] Organ transplantation is the main method for treating chronic end-stage diseases such as liver, kidney and heart, and suppression of rejection is one of the key factors restricting the long-term survival of transplanted organs. Parasites can invade hosts with normal immune function, and can evade the host's immune effects, develop, reproduce, and survive. This phenomenon is called immune evasion. Psoriasis larvae can migrate in the host tissue for 8 months, and the four serine proteases dermatoxin A, B, C, and D secreted by it have an immunosuppressive effect on the host, so that the host cannot use the immune function to kill the fly larvae. The immunoregulatory function of HA suppres...

Claims

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