Application of borneol in preparing epilepsy treatment drug and drug comprising borneol

A technology of therapeutic effect and borneol, which is applied to medical preparations containing active ingredients, drug combinations, active ingredients of hydroxyl compounds, etc., can solve the problems of many peripheral adverse reactions, difficult treatment, and intolerance of patients.

Inactive Publication Date: 2015-04-08
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the effect of the blood-brain barrier, only a very small amount of drugs for the treatment of brain diseases enter the blood brain, and the peripheral concentration is high, so the treatment is difficult, the peripheral adverse reactions are many, and even the patient cannot tolerate it.

Method used

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  • Application of borneol in preparing epilepsy treatment drug and drug comprising borneol
  • Application of borneol in preparing epilepsy treatment drug and drug comprising borneol

Examples

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Effect test

Embodiment 1

[0016] A pharmaceutical composition for treating epilepsy, the active ingredients of which are borneol and phenytoin, wherein the borneol contains 5 parts, and the phenytoin contains 0.1 part. During preparation, the composition can be prepared into various required dosage forms, such as tablets, granules, capsules, etc., by adding pharmaceutically acceptable adjuvants. When taking it, the usage amount is determined according to the content of phenytoin sodium in the preparation.

Embodiment 2

[0018] A medicinal composition for treating epilepsy, the active ingredients of which are borneol and phenytoin, wherein the borneol contains 5 parts, and the phenytoin contains 0.2 parts. During preparation, the composition can be prepared into various required dosage forms, such as tablets, granules, capsules, etc., by adding pharmaceutically acceptable adjuvants. When taking it, the usage amount is determined according to the content of phenytoin sodium in the preparation.

Embodiment 3

[0020] A pharmaceutical composition for treating epilepsy, the active ingredients of which are borneol and phenytoin, wherein the borneol contains 10 parts, and the phenytoin contains 0.1 part. During preparation, the composition can be prepared into various required dosage forms, such as tablets, granules, capsules, etc., by adding pharmaceutically acceptable adjuvants. When taking it, the usage amount is determined according to the content of phenytoin sodium in the preparation.

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Abstract

The invention discloses an application of borneol in preparing an epilepsy treatment drug, mainly an application of the borneol in combination with western medicine which has a therapeutical effect in epilepsy in preparing the epilepsy treatment drug. The invention also discloses the drug comprising the borneol. The drug comprises the western medicine and the borneol, the borneol content is 1 to 10 g when the western medicine content is one third to one time of single dosage of the western medicine in treating the epilepsy. According to the application of the borneol in preparing the epilepsy treatment drug, a new application of the borneol is discovered, the western medicine absorption is increased, the western medicine is prompted to enter blood-brain, the western medicine concentration entering the blood-brain is prompted, the treatment effect of the western medicine is improved, meanwhile accumulation of the western medicine at the periphery of a brain is reduced, adverse effects are reduced, and accordingly the dosage of the western medicine is reduced to be one third of the original dosage, the adverse effects are further reduced, economical burden of a patient is reduced, pain from the adverse effects are reduced, and a patient is easy to accept.

Description

technical field [0001] The invention relates to a new application of borneol, in particular to a new application of borneol in the preparation of drugs for treating epilepsy and the obtained epilepsy drug containing borneol. Background technique [0002] Epilepsy is a chronic recurrent short-term brain dysfunction syndrome characterized by repeated epileptic seizures caused by abnormal discharge of brain neurons. Epilepsy is one of the common diseases of the nervous system, second only to stroke in prevalence. The incidence of epilepsy is related to age. It is generally believed that the prevalence rate is the highest within 1 year old, followed by a gradual decrease after 1 to 10 years old. [0003] At present, the treatment of epilepsy is mainly based on chemical drug therapy. Commonly used drugs for the treatment of epilepsy include phenytoin, carbamazepine, and ethosuximide. The dosage of phenytoin sodium is 0.3-0.6g / time, divided into 2-3 times or once in the evening...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61K31/4166A61P25/08
CPCA61K31/045A61K31/4166A61K2300/00
Inventor 孙明江刘源香孙敬昌石仲歌
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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