High-efficiency high-yield preparation method of panax notoginseng extract
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An extraction and high-yield technology, applied in the field of medicine, can solve the problems of loss of active ingredients of Panax notoginseng, long time of percolation, and difficulty in industrial application
Active Publication Date: 2015-04-08
云南云药中药资源开发利用有限公司
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Since the plant cells have been dehydrated, the active ingredients must be dissolved from the dry and solidified cells. Despite the adoption of various modern methods and technologies, there are still constraints between cost and yield.
[0004] Panax notoginseng is known for its hard texture and is described as a "copper-skinned iron bone lion's head". It is more time-consuming and labor-intensive to crush it, and the continuous high temperature during the drying and crushing process causes a greater loss of active ingredients in
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[0016] The high-efficiency and high-yield preparation method of the Radix Notoginseng extract of the present invention uses fresh Radix Notoginseng as a raw material, and obtains it through homogenization, freeze-drying, and extraction steps, specifically comprising:
[0017] A. Homogenization: Take fresh Sanqi as raw material, add water with a weight ratio of 0.05 to 0.50 times to homogenate to obtain Panax notoginseng slurry;
[0018] B. Freeze-drying: Freeze-drying the notoginseng slurry prepared in step A to obtain notoginseng powder;
[0019] C. Extraction:
[0020] Method 1: add an ethanol solution with a weight ratio of 3 to 8 times to the notoginseng slurry prepared in step A, extract at a temperature of 20 to 35°C for 0.5 to 3.0 hours, filter and concentrate to obtain the target notoginseng extract;
[0021] Method 2: Add the notoginseng powder prepared in step B to an ethanol solution with a weight ratio of 5 to 15 times, extract at a temperature of 20 to 35°C for 1...
Embodiment 1
[0035] Take 50 kg of fresh Panax notoginseng, add 15 kg of water and 5 kg of ice cubes, and homogenize it in a homogenizer for 40 minutes to obtain a panax notoginseng slurry. Add 8 times the weight of 60% ethanol solution to the slurry and extract at 20°C for 3 hours. The extract was filtered under reduced pressure to remove the filter residue, and the filtrate was concentrated and dried under reduced pressure to obtain the target Panax notoginseng extract.
[0036] It has been tested that the Panax notoginseng extract contains 83% of the total saponins of Panax notoginseng, of which Panax notoginseng saponin R1 accounts for 8%, ginsenoside Rg 1 Accounted for 32%, ginsenoside Re accounted for 5%, ginsenoside Rb 1 Accounted for 37%, ginsenoside Rd accounted for 9%, accounting for 91% of the total saponins.
Embodiment 2
[0038] Take 80kg of fresh Panax notoginseng, add 40kg of water and 18kg of ice cubes, and homogenize it in a homogenizer for 45 minutes to obtain a panax notoginseng slurry. Add 3 times the weight of 90% ethanol solution to the slurry and extract at 35°C for 0.5h. The extract was filtered under reduced pressure to remove the filter residue, and the filtrate was concentrated and dried under reduced pressure to obtain the target Panax notoginseng extract.
[0039] After testing, the Panax notoginseng extract contains 89% of the total saponins of Panax notoginseng, of which Panax notoginsenoside R1 accounts for 7%, ginsenoside Rg 1 34%, ginsenoside Re 4%, ginsenoside Rb 1 Accounted for 39%, ginsenoside Rd accounted for 8%, accounting for 92% of the total saponins.
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Abstract
The invention discloses a high-efficiency high-yield preparation method of a panax notoginseng extract. The high-efficiency high-yield preparation method of the panax notoginseng extract comprises the steps of taking fresh panax notoginseng as a raw material, homogenizing, performing freeze drying and extracting. The method specifically comprises the following steps: taking the fresh panax notoginseng as the raw material, adding water according to the weight ratio of 0.05-0.50 time, homogenizing to obtain a panax notoginseng slurry, and performing freeze drying, thereby obtaining panax notoginseng powder; adding an ethanol solution in a weight amount of 3-8 times into the panax notoginseng slurry, leaching at the temperature of 20-35 DEG C for 0.5-3.0 hours, filtering, and concentrating, thereby obtaining a target panax notoginseng extract; and adding an ethanol solution in a weight amount of 5-15 times into the panax notoginseng slurry, leaching at the temperature of 20-35 DEG C for 1-4 hours, filtering, and concentrating, thereby obtaining the target panax notoginseng extract. By utilizing the characteristics that fresh panax notoginseng cells are full, the cell structure is easy to damage and the active ingredients can be efficiently dissolved, the panax notoginseng powder is prepared by combining a low-temperature freeze drying method by adopting a homogenizing technology; and moreover, the characteristic that the active ingredients are free in the panax notoginseng powder and are easy to dissolve is utilized, the active ingredients can be directly extracted and enriched, the panax notoginseng extract is prepared, and the defects of the traditional method for preparing the panax notoginseng powder by disintegrating the panax notoginseng medicinal materials and performing reflux extraction to produce the panax notoginseng extract are overcome.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a high-efficiency and high-yield preparation method of a Panax notoginseng extract. Background technique [0002] Panax notoginseng is the dry root of Panax notoginseng (Burk) F. H. Chen. Panax notoginseng was first recorded in "Compendium of Materia Medica", and modern "Chinese Materia Medica" listed it as a blood-invigorating medicine. Traditional Chinese medicine is used as a medicine for removing blood stasis and stopping bleeding, reducing swelling and analgesia. It has the characteristics of "stopping bleeding without leaving stasis". Panax notoginseng contains saponins, notoginseng, flavonoids, volatile oils, amino acids, sugars and other active ingredients. Its total saponin content is about 12%, which is the main active ingredient of panax notoginseng. Modern pharmacological research has found that the pharmacological activity of the total saponins of Pana...
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