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Method for modifying polyether-ether-ketone surface

A polyetheretherketone modification technology, which is applied in the field of surface modification of biomedical polymer materials, can solve problems affecting the normal activities of cells, and achieve stable and controllable preparation processes, easy popularization and application, and good antibacterial properties

Active Publication Date: 2015-04-08
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Recently, studies have shown that the surface of PEEK after sulfonation can form a three-dimensional pore structure that is conducive to cell adhesion and proliferation (Biomaterials.2013; 34:9264-77.), but the micro-mesoporous structure formed on the surface of PEEK after sulfonation Some harmful S-series compounds will remain, and these S-series compounds will affect the normal activities of cells

Method used

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  • Method for modifying polyether-ether-ketone surface
  • Method for modifying polyether-ether-ketone surface
  • Method for modifying polyether-ether-ketone surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] a) The medical PEEK material is washed three times with ethanol, acetone, and deionized water after polishing; b) The magnet is placed in concentrated sulfuric acid, stirred at a speed of 300r / min in a magnetic stirrer, and the PEEK is placed in Among them, react for 5 minutes, place the sulfonated PEEK in deionized water, soak for 5 minutes, take it out and dry it naturally to obtain a modified layer with a three-dimensional pore structure; c) place the sulfonated PEEK in deionized water at 80°C After hydrothermal treatment in a hydrothermal kettle for 24 hours, the sample was taken out, rinsed, and dried naturally to obtain a modified layer with a three-dimensional pore structure without S.

[0062] Fig. 1 (a), Fig. 1 (b), Fig. 1 (c) are related accompanying drawings in the embodiment; As can be seen from Fig. 1 (a), Fig. 1 (b), Fig. 1 (c), sulfonation The treatment can form a three-dimensional channel structure on the surface of PEEK, and the hydrothermal treatment w...

Embodiment 2

[0067] a) The medical PEEK material is washed three times with ethanol, acetone, and deionized water after polishing; b) The magnet is placed in concentrated sulfuric acid, stirred at a speed of 300r / min in a magnetic stirrer, and the PEEK is placed in Wherein reaction 5min, the PEEK after sulfonation is placed in deionized water, soaks 5min, takes out and dries naturally, obtains the modified layer with three-dimensional pore structure; After hydrothermal treatment in a hydrothermal kettle for 24 hours at ℃, the sample was taken out, rinsed, and dried naturally to obtain a modified layer with a three-dimensional pore structure without S;

[0068] Figure 2(c) is the EDS spectrum of the PEEK that has undergone vulcanization treatment and hydrothermal treatment in this example. It can be seen that most of the S in the three-dimensional pore structure can be removed by hydrothermal treatment with dilute hydrochloric acid as the hydrothermal medium at 80 °C. .

Embodiment 3

[0070] a) The medical PEEK material is washed three times with ethanol, acetone, and deionized water after polishing; b) The magnet is placed in concentrated sulfuric acid, stirred at a speed of 300r / min in a magnetic stirrer, and the PEEK is placed in Wherein react for 5min, place the PEEK after sulfonation in deionized water, soak for 5min, take out and dry naturally, obtain the modified layer with three-dimensional pore structure; c) place the PEEK after sulfonation in de-diluted sodium hydroxide After hydrothermal treatment in a hydrothermal kettle at 80°C for 24 hours, the sample was taken out, rinsed, and dried naturally to obtain a modified layer with a three-dimensional pore structure without S;

[0071] Figure 2(d) is the EDS spectrum of the PEEK that has undergone vulcanization treatment and hydrothermal treatment in this example. It can be seen from it that the hydrothermal treatment with dilute sodium hydroxide as the hydrothermal medium at 80°C can remove part of t...

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Abstract

The invention relates to a method for modifying a polyether-ether-ketone surface. The method comprises the following steps: firstly, carrying out sulfonation treatment on polyether-ether-ketone with concentrated sulfuric acid, so as to form a modification layer with a three-dimensional open-framework structure on the polyether-ether-ketone surface; taking out a polyether-ether-ketone block material for washing after sulfonation treatment is ended; and carrying out hydrothermal treatment, so as to remove the residual sulphur in the three-dimensional open-framework structure.

Description

technical field [0001] The invention relates to a method for modifying the surface of PEEK, in particular, relates to a method for sulfonating it with concentrated sulfuric acid, and then undergoing hydrothermal treatment to obtain a PEEK surface modification layer with a three-dimensional network structure that removes S The invention belongs to the technical field of surface modification of biomedical polymer materials. Background technique [0002] Polyetheretherketone (PEEK), a semi-crystalline polymer, has a crystallinity of 30-35% and a glass transition temperature of 143°C. Because of its radiolucency, PEEK has mechanical properties similar to human bone (J. Reinf. Plast. Compos. 22 (2003) 751–767), and has good thermoplasticity, easy to make the desired bone shape, and its elasticity is close to that of human bone. (Biomaterials 28 (2007) 4845–4869) has thus become a favored material for medical implant devices. However, the bioactivity of polyetheretherketone is p...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08J7/14A61L27/18A61L27/56C08L61/16
Inventor 刘宣勇欧阳丽萍
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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