Medicinal composition of paclitaxel

A composition and technology of paclitaxel, which are applied in the directions of drug combination, anti-tumor drug, powder delivery, etc., can solve the problems of large particle size and complicated process of paclitaxel freeze-dried powder, and achieve the advantages of avoiding adverse reactions, simple preparation process and blood stability. high effect
CN104511022AInactive Publication Date: 2015-04-15POLYMERCHEM
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
POLYMERCHEM
Publication Date
2015-04-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of medicinal preparations, and concretely relates to a medicinal composition of paclitaxel. The medicinal composition comprises, by weight, 2.87-27.66 parts of paclitaxel and 100 parts of mPEG-PLA-phenylalanine. The medicinal composition has the following advantages: 1, the in vitro stability is high, and a re-dissolved paclitaxel solution keeps stable at room temperature for above 12h to meet medicinal treatment requirements; 2, the medicinal composition has high stability in blood and small particle size, and can easily perform the ERP effect; 3, a novel micelle carrier is adopted, so the toxicity is low, and the safety is high; and 4, a pharmacy common freeze-drying technology is directly adopted to prepare freeze-dried powder, so the medicinal composition is simple to prepare, and is convenient to transport and store, and untoward effects brought by the addition of an excipient are avoided The medicinal composition can be instantly re-dissolved by using common normal saline or glucose injection, so the administration process is greatly simplified.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition and preparation containing paclitaxel. Background technique

[0002] The molecular formula of paclitaxel is: C 47 h 51 NO 14 , molecular weight 853.9, melting point 213-216 ℃, highly lipophilic, insoluble in water, is a highly efficient, low toxicity, broad-spectrum natural anticancer drug isolated from Taxus genus. It is a complex natural secondary metabolite in Taxus plants, and its molecular structure is shown in the following formula.

[0003]

[0004] Paclitaxel is a microtubule-specific drug with high anti-cancer activity. Its sales volume ranks first among new anti-tumor drugs all the year round, and is increasing at a rate of 20%.

[0005] In 1977, Horwit Z discovered that the anti-cancer mechanism of paclitaxel lies in its ability to bind to tubulin, promote tubulin polymerization and assemble into microtubule dimer...

Claims

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