A method of manufacturing a microfluidic chip

Abstract

The invention discloses a method for manufacturing a microfluidic chip, comprising the following steps: preparing a first base material with a microchannel; preparing a second base material for encapsulating the first base material; The first base material and the second base material are pressed together; wherein the order of preparation of the first base material and the second base material is in no particular order. The present invention does not need to modify the base material, thereby reducing process steps and equipment investment, increasing work efficiency, and greatly reducing production costs; it is not limited by modification treatment equipment, so it can solve the problem of existing equipment preparation The bottleneck of chips with a size exceeding 20 inches can prepare large-sized chips at one time, which can greatly improve the production capacity of microfluidic chips.

Description

technical field [0001] The invention relates to a method for manufacturing a microfluidic chip. Background technique [0002] Microfluidic chip laboratory, also known as microfluidics or lab-on-chip, is a separation and analysis method that has developed rapidly in recent years. It can process samples, inject samples, All the operations of the process of separation and detection are concentrated on a chip of a few square centimeters. Due to the reduced volume, it not only reduces the consumption of reagents and samples by thousands of times compared with conventional analysis methods, but also greatly improves the speed of analysis and separation. This new method will become an important method in gene polymorphism analysis, proteome analysis, drug screening and clinical diagnosis in the post-genome era, so it has very attractive commercial prospects. [0003] The core technology of this new method lies in the packaging process of microfluidic chips. In recent years, peop...

AI Technical Summary

Problems solved by technology

Oxygen plasma gas cleaning requires a vacuum link, and the vacuum cleaning chamber will greatly increase the manufacturing cost when performing large-scale cleaning, thus greatly limiting the possibility of mass production of microfluidic chips

At the same time, because oxygen plasma surface modification has a certain time limit, it is difficult to do it when preparing a relatively complex double-layer microfluidic chip structure, especially in the process of aligning microfluidic channels between the upper and lower substrates. to precise control