Method for improving hydrophily and flexibility of polypeptide membrane by polycarbamate and polyethylene glycol
A technology of polyurethane and polyethylene glycol is applied in the field of polymer film preparation to achieve the effect of simple operation and easy mastery
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Embodiment 1
[0019] 1) Synthesis of Polyurethanes Containing Terminal -COOH Groups
[0020] Add 5.5 grams of 2,4-toluene diisocyanate and 17 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 350 ml of dimethylformamide solvent, and add di Dibutyltin laurate, under an inert atmosphere, stirred and reacted at 40°C for 40 minutes, then added 0.8 g of 1,4-butanediol and reacted for 10 minutes, then added 1.2 g of 3-hydroxypropionic acid and reacted for 5 minutes to terminate the reaction and obtain the target thing;
[0021] 2) Synthesis of Polypeptide-Polyurethane Block Copolymer
[0022] Add 16 g of poly(r-benzyl-L-glutamate) (molecular weight 80,000) and 9 g of polyurethane containing terminal -COOH groups into a dry reactor, add 300 ml of dimethyl formamide, add another 0.045 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 20°C for 3 days, then terminated the reaction, filtered, dialyzed, and dried to obtain ...
Embodiment 2
[0029] 1) Synthesis of Polyurethanes Containing Terminal -COOH Groups
[0030] Add 6.05 grams of 2,4-toluene diisocyanate and 19 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 353 ml of dimethylformamide solvent, and add di Dibutyltin laurate, under an inert atmosphere, stirred and reacted at 45°C for 45 minutes, then added 0.88 g of 1,4-butanediol and reacted for 12 minutes, then added 1.3 g of 3-hydroxypropionic acid and reacted for 7 minutes to terminate the reaction and obtain the target thing;
[0031] 2) Synthesis of Polypeptide-Polyurethane Block Copolymer
[0032] Add 16.5 g of poly(r-ethyl-L-glutamate) (molecular weight: 85,000) and 9 g of polyurethane containing terminal -COOH groups into the dry reactor, add 310 ml of dimethylformaldehyde amide, add 0.027 g N,N' -Diisopropylcarbodiimide, under an inert atmosphere, stirred at 25°C for 4 days, then terminated the reaction, filtered, dialyzed, and dried to obtain the tar...
Embodiment 3
[0039] 1) Synthesis of Polyurethanes Containing Terminal -COOH Groups
[0040]Add 6.6 grams of 2,4-toluene diisocyanate, 21 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 360 ml of dimethylformamide solvent, and add di Dibutyltin laurate, under an inert atmosphere, stirred and reacted at 50°C for 50 minutes, then added 0.92 g of 1,4-butanediol to react for 15 minutes, then added 1.84 g of 3-hydroxypropionic acid to react for 10 minutes, terminated the reaction, and obtained the target thing;
[0041] 2) Synthesis of Polypeptide-Polyurethane Block Copolymer
[0042] Add 16.8 g of poly(r-methyl-L-glutamate) (molecular weight: 90,000) and 9.9 g of polyurethane containing terminal -COOH groups into the dry reactor, add 315 ml of dimethylformaldehyde Amide, then add 0.046 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir and react at 30°C for 3 days, then terminate the reaction, filter, dialyze, and ...
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