A Computational Chip Imaging Biosensing Platform Using Surface Plasmon Chips

Abstract

The invention discloses a computing chip imaging biosensing platform capable of utilizing a surface plasma chip. The biosensing platform comprises the surface plasma chip and a CCD image sensor, wherein the surface plasma chip comprises one or more microarray pixels manufactured on a metallic membrane layer of a glass base; each microarray pixel comprises a periodic metal nanowire array; each microarray pixel is a separate unit in X direction and the Y direction; the surface plasma chip serves as a sensing chip; the CCD image sensor serves as a detecting element, is attached to the reverse side of the glass base of the surface plasma chip and used for recording the diffraction image of each microarray pixel and obtaining the concentration or intermolecular interaction information of a to-be-detected albuminous membrane layer through analyzing the diffraction image. The biosensing platform has the characteristics of compact structure, light weight, lens-free integrated chip imaging, zero chemical reaction process, and zero mark detection.

Description

technical field [0001] The invention relates to a biosensor used in the fields of disease screening and epidemic prevention, in particular to a computational chip imaging biosensing platform using a surface plasmon chip in a surface plasmon mode. Background technique [0002] Effective diagnosis and examination are crucial for disease screening and epidemic prevention. Most of the current medical examination methods are time-consuming and expensive chemical processes, especially in developing countries, there is an urgent need for an effective and easy-to-operate detection method. [0003] A biosensor is an instrument that is sensitive to biological substances and converts its concentration into an electrical signal for detection. It uses biologically sensitive materials as identification elements (such as enzymes, antibodies, nucleic acids and other biologically active substances) and appropriate physical and chemical transducers. (such as oxygen electrode, photosensitive ...

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Problems solved by technology

[0004] However, at present, the wide application of biosensors still faces some difficulties, such as the selection of biosensing elements with strong activity and high selectivity; the improvement of the service life of the signal detector; the improvement of the service life of the signal converter; the biological response stability and the miniaturization and portability of biosensors

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