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A kind of pharmaceutical composition containing bismuth potassium citrate

A technology of potassium bismuth citrate and a composition, applied in the field of medicine, can solve problems such as adverse reactions, influence curative effect, restrict the use of potassium bismuth citrate, etc., and achieve simple and easy production operation, high dissolution rate and good stability Effect

Active Publication Date: 2017-08-15
长春海悦药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Bismuth potassium citrate has been used in the treatment of gastrointestinal ulcers for many years. However, due to the concentration accumulation of bismuth in the brain, bones, etc. during the course of taking the medicine, causing certain adverse reactions, the course of treatment should not be longer than 28 days. The use of bismuth potassium citrate
[0005] In bismuth potassium citrate, metronidazole, and tetracycline hydrochloride compound preparations, the interaction between tetracycline hydrochloride and bismuth potassium citrate affects its curative effect

Method used

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  • A kind of pharmaceutical composition containing bismuth potassium citrate
  • A kind of pharmaceutical composition containing bismuth potassium citrate
  • A kind of pharmaceutical composition containing bismuth potassium citrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] prescription

[0068]

[0069] Preparation

[0070] (1) Pass tetracycline hydrochloride and metronidazole through a 60-mesh sieve, make soft material with water, pass through a 60-mesh sieve, and set aside;

[0071] (2) For the granules obtained in the drying step (1), control the moisture content to be less than or equal to 1%;

[0072] (3) Polyacrylic resin IV is mixed with 95% ethanol to make a coating liquid;

[0073] (4) Coating the granules obtained in step (2) with the coating liquid obtained in step (3);

[0074] (5) Mix the coated granules obtained in step (4) with the prescription amount of potassium bismuth citrate and micro-powdered silica gel uniformly, and fill them into capsules.

Embodiment 2

[0076] prescription

[0077]

[0078] Preparation

[0079] (1) Pass tetracycline hydrochloride and metronidazole through a 60-mesh sieve, make soft material with water, pass through a 60-mesh sieve, and set aside;

[0080] (2) For the granules obtained in the drying step (1), control the moisture content to be less than or equal to 1%;

[0081] (3) Polyacrylic resin IV is mixed with 95% ethanol to make a coating liquid;

[0082] (4) Coating the granules obtained in step (2) with the coating liquid obtained in step (3);

[0083] (5) Mix the coated granules obtained in step (4) with the prescription amount of potassium bismuth citrate and talc evenly, and fill them into capsules.

Embodiment 3

[0085] prescription

[0086]

[0087] Preparation

[0088] (1) Pass tetracycline hydrochloride and metronidazole through a 60-mesh sieve, make soft material with water, pass through a 60-mesh sieve, and set aside;

[0089] (2) For the granules obtained in the drying step (1), control the moisture content to be less than or equal to 1%;

[0090] (3) Polyacrylic resin IV is mixed with 95% ethanol to make a coating liquid;

[0091] (4) Coating the granules obtained in step (2) with the coating liquid obtained in step (3);

[0092] (5) Mix the coated granules obtained in step (4) with the prescription amount of potassium bismuth citrate and micro-powdered silica gel uniformly, and fill them into capsules.

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Abstract

The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition containing bismuth potassium citrate and a preparation method thereof. The pharmaceutical composition contains bismuth potassium citrate, metronidazole and tetracycline hydrochloride. The product of the invention has good stability, complete stripping and better product quality; the product of the invention is easy to operate and is suitable for industrial production.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition containing potassium bismuth citrate and a preparation method of its capsule. Background technique [0002] Diseases of the digestive tract are common and frequently-occurring diseases. Among the diseases of the system, the stomach and duodenum have the highest morbidity. The number of patients affected accounts for more than 10% of the world's population. Gastrointestinal ulcer is one of the main diseases affecting human health. Therefore, it is a hot spot in the field of drug research and development in my country to find anti-ulcer drugs with good curative effects and low prices. [0003] Potassium bismuth citrate is a bismuth-containing compound with indefinite composition. It is a white powder with a salty taste. It is easily soluble in water and minimally soluble in ethanol. Bismuth potassium citrate is dissolved by quantitative hot water ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/65A61K9/48A61P1/00A61P1/04A61K31/194A61K31/4164
Inventor 贾敬琼谭中英王晓录权超
Owner 长春海悦药业股份有限公司