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Use of salidroside in preparation of drug for promoting bone fracture repair

A technology of salidroside and fractured bone, which is applied in the directions of drug combination, bone disease, pharmaceutical formulation, etc., to achieve good clinical application prospects, and the effect of promoting osteogenesis and angiogenesis.

Inactive Publication Date: 2015-05-13
LOGISTICS UNIV OF CAPF
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  • Summary
  • Abstract
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  • Claims
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Problems solved by technology

At present, there is no report on the role of SAL in the bone regeneration process of fractures

Method used

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  • Use of salidroside in preparation of drug for promoting bone fracture repair
  • Use of salidroside in preparation of drug for promoting bone fracture repair
  • Use of salidroside in preparation of drug for promoting bone fracture repair

Examples

Experimental program
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Embodiment 1

[0027] 1. Method

[0028] 1.1 Establishment of mouse tibial fracture model

[0029] This study was improved based on the unstable fracture animal model described by Choi P et al. (Cellular and molecular characterization of a murine non-union model. J Orthop Res, 2004, 22:1100-7). 6-8 weeks old clean grade male Kunming white mice, weighing 22-28 g, were anesthetized by intraperitoneal injection of 2.5% Avertin (Avertin) at 0.012-0.018 ml / g (body weight). After the mice were fully anesthetized, the skin was prepared and the right lower limbs of the mice were disinfected. A longitudinal incision of about 8 mm was made under the right knee joint of the mice. After the muscle fascia was separated, the middle and upper third of the tibia was cut with ophthalmic scissors. The tibia was rinsed with sterile PBS, and the incision was sutured layer by layer. Mice were housed in single cages at a room temperature of 22-24°C, provided with standard feed, free to eat, drink and move freel...

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Abstract

The invention discloses use of salidroside in preparation of a drug for promoting bone fracture repair, and effect of the salidroside in promotion of bone regeneration and bone fracture repair can be observed by a mice tibial fracture model. The results show that the salidroside has a significant role in promotion of osteogenesis and angiogenesis the process of bone regeneration, and so that the salidroside has a good prospect in clinical application.

Description

technical field [0001] The present invention relates to the use of a medicine, in particular to the use of salidroside in preparing a medicine for promoting fracture bone repair. Background technique: [0002] In the process of bone development and bone repair, the vascularization of bone tissue plays a very important role. Bone tissue has a rich blood supply, and its blood flow accounts for about 10% of cardiac output. The body mainly relies on red blood cells to carry oxygen to supply the growth, development and metabolism of tissue cells. The normal tissue oxygen concentration of the human body fluctuates between 5% and 12%. %between. Hypoxia often occurs where the blood flow is interrupted or reduced. When the blood flow is interrupted in a fracture, the partial pressure of oxygen in the center of the wound is even reduced to 0% to 2%. At present, a large number of studies have shown that bone formation is closely related to angiogenesis, and many local or systemic is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P19/08A61P9/00
Inventor 王越张晓雷郭小芹李玲杨静祁琳李宗旻牛秀珑屈野
Owner LOGISTICS UNIV OF CAPF
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