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Reflective split-pupil confocal-photoacoustic microscopy imaging device and method

A photoacoustic microscopy and imaging device technology, applied in the direction of material excitation analysis, etc., can solve the problems of inability to realize cell structure images, etc., and achieve the effects of easy miniaturization and hand-held, increased working distance, and improved axial resolution

Active Publication Date: 2017-05-31
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the resolution of photoacoustic imaging is only up to 10 microns, and it cannot realize structural images at the cellular level

Method used

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  • Reflective split-pupil confocal-photoacoustic microscopy imaging device and method
  • Reflective split-pupil confocal-photoacoustic microscopy imaging device and method
  • Reflective split-pupil confocal-photoacoustic microscopy imaging device and method

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Embodiment 1

[0037] The embodiment of the present invention is based on Figure 4 The reflective split-pupil confocal-photoacoustic microscopy imaging device shown includes a point light source system 1 composed of a laser 14, a focusing mirror 13 and a first pinhole 12, and a collimating mirror 3 placed in the direction of travel of the pulse beam 2 in sequence , a reflective condenser 4, an aberration compensating hemispherical mirror 7, a three-dimensional beam scanner 8 and a sample to be tested 11, and an acoustic lens 6 and an ultrasonic transducer 5 that are placed in the backscattering direction of the sample 11 to detect photoacoustic signals in sequence, And a reflective split-pupil confocal detection system for detecting the backscattered light or fluorescence signal of the sample under test 11; wherein, the reflective split-pupil confocal detection system includes: aberrations placed in sequence along the backscattering direction of the measured sample Compensation hemispherica...

Embodiment 2

[0070] Such as figure 2 As shown, in the reflective split-pupil confocal-photoacoustic microscopy imaging device of Embodiment 1, the point light source system 1 is replaced by an exit optical fiber 17 . The pulse beam 2 emitted by the output fiber 17 is focused on the sample 11 to excite a photoacoustic signal, scattered light or fluorescence signal after being passed through the collimating mirror 3, the reflective condenser mirror 4, and the aberration compensating hemispherical mirror 7.

[0071] In the reflective split-pupil confocal-photoacoustic microscopy imaging device of Embodiment 1, the point detector 10 is replaced by a detection fiber 18 . The scattered light or fluorescent signal of the measured sample excited by the focused beam is focused to the detection fiber 18 for detection through the aberration compensating hemispherical mirror 7, the three-dimensional beam scanner 8, the reflecting condenser mirror 4, and the collecting mirror 9.

[0072] All the othe...

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Abstract

The invention relates to a reflection type spectral pupil confocal-photoacoustic microimaging device and method. The structures and the functions of a reflection type spectral pupil confocal microimaging system and a photoacoustic imaging system are organically combined on the basis of a spectral pupil confocal microimaging system with a large working distance, high axial resolution and stray light interference resistance; the reflection type spectral pupil confocal microimaging system is used for detecting spatial structure information of a biological sample, and the photoacoustic microimaging system is used for detecting functional information of the biological sample, so that simultaneous detection of the spatial structure information and the functional information of the biological sample can be realized, and in-situ and noninvasive real-time imaging of a biological living body is expected to be realized. By adoption of a spectral pupil confocal imaging technology, the axial resolution and the working distance of the spectral pupil differential confocal-photoacoustic microimaging device can be effectively compatible, so that interference of stray light on a focal surface on the a high-stray sample can be suppressed; the signal-to-noise ratio of the system is high; therefore, integrated and handheld design of the spectral pupil confocal-photoacoustic microimaging device can be facilitated.

Description

technical field [0001] The invention relates to a reflective split-pupil confocal-photoacoustic microscopic imaging device and method, and belongs to the technical fields of confocal microscopic imaging technology and photoacoustic microscopic imaging technology. [0002] technical background [0003] Due to its unique tomographic imaging capability and high spatial resolution capability in the optical field, confocal microscopy imaging technology has been widely used as an important technical means in biomedical research, physical chemistry research, material testing, micro-nano testing and other fields. However, the existing confocal microscopic imaging technology mainly uses the scattered light or fluorescence of the object for imaging, which only obtains the structural image of the observed object, and cannot obtain the functional image of cells or biological macromolecules. The depth is only on the order of submillimeters. [0004] Photoacoustic imaging is based on the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/63
Inventor 赵维谦王允
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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