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Preparation method of a gradient β-phase tricalcium phosphate bone substitute material

A technology of interphase tricalcium phosphate bone and phase tricalcium phosphate, applied in medical science, prosthesis, etc., can solve the problems of poor biological functionality and low compressive strength, and achieve low porosity, high compressive performance, and strengthened bonding sexual effect

Inactive Publication Date: 2016-08-31
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing a gradient β-phase tricalcium phosphate bone substitute material, which solves the problems of low compressive strength and poor biological functionality of the gradient bone substitute material prepared by existing materials and technologies, and can efficiently prepare vertical bone substitute materials. Bone substitute material with longer dimensions

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  • Preparation method of a gradient β-phase tricalcium phosphate bone substitute material
  • Preparation method of a gradient β-phase tricalcium phosphate bone substitute material

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preparation example Construction

[0030] The preparation method of gradient structure comprises the following steps:

[0031] ①Blank pressed layer by layer: stainless steel mold is used, and the mark of the molding mold is M n , n=1, 2, 3, 4....., 4≤n≤12, where the molding die M n The outer radius is greater than the molding die M n-1 The outer radius of the raw material is pressed from the outermost layer to the inside according to the corresponding order, and the pressing pressure is P 1 , 60MPa≤P 1 ≤200MPa, pressing is divided into four stages, and the holding time of each stage is t 1 , t 2 , t 3 , t 4 , 15s≤t 1 , t 2 , t 3 ≤120s, 600s≤t 4 ≤800s, deflation time is t ' 1 , t ' 2 , t ' 3 , 15s≤t ' 1 , t ' 2 , t ' 3 ≤150s;

[0032] The molded blank is marked as F n , n=1, 2, 3, 4....., 4≤n≤12, the blank interface is semi-circular, and the outer diameter is R no , the inner diameter is R ni , n=2, 3, 4....., 4≤n≤12, and the inner and outer diameters of two adjacent billets satisfy R...

preparation example

[0041] First weigh 80g of β-phase tricalcium phosphate and 20g of polyvinyl alcohol and mix them, then add stearic acid to it, the amount of stearic acid added in the raw materials decreases layer by layer from the inside to the outside, respectively 50.00g, 45.13g, 42.87g, 40.73 g, using a rolling mixer for mixing, the mixing speed is 50r / min, and the mixing time is 30min. A total of 4 groups of mixed materials are prepared, which are marked as T from the inside to the outside. 1 ,T 2 ,T 3 ,T 4 ;

[0042] ①Blank pressed layer by layer: stainless steel mold is used, and the mark of the molding mold is M n , n=1, 2, 3, 4, where the molding die M n The outer radius of the mold should be greater than that of the molding die M n-1 The outer radius, the raw material T n Press from the outermost layer to the inside according to the corresponding order, and the pressing pressure is P 1 , P 1 =100MPa, the pressing is divided into four stages, and the holding time of each stage...

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Abstract

The invention discloses a preparation method of a gradient β-phase tricalcium phosphate bone substitute material. The method is to compress the blanks of β-phase tricalcium phosphate, binder, porogen-gas generating agent and surfactant layer by layer, and adopt Surfactants are used for surface activation treatment, layer-by-layer assembly and composite sintering to prepare the gradient β-phase tricalcium phosphate bone substitute material. The binder is polyvinyl alcohol powder of 120 mesh to 200 mesh; the porogen-gas generating agent is stearic acid; the surfactant is titanium dioxide suspension. The bone substitute material prepared by the present invention has good biocompatibility and interface biological activity, and can be used in the research and application of bone-like materials. The structure design of the bone substitute material is based on the principle of bionics, imitating the human skeleton, which is dense on the outside and sparse on the inside. The structure, that is, the gradient distribution structure whose porosity increases layer by layer from the outside to the inside, provides a channel and space for the growth of fibroblasts and bone cells into the material, increases the bonding area between new bone and the material, and has good mechanical properties, close to human bone .

Description

technical field [0001] The invention relates to a preparation method of a gradient β-phase tricalcium phosphate bone substitute material. Background technique [0002] As an important part of the human body, bones play an irreplaceable role in protecting and supporting various organs of the human body. At the same time, they are also responsible for supporting the trunk, hematopoiesis, calcium storage, and metabolism. They are the foundation of human life. Skeletal injuries can cause great damage to the human body, and most bone defects cannot heal on their own, requiring bone substitute material transplantation. There are a variety of bone substitute materials that can be used for bone grafting, generally including metal materials, non-metal materials, and polymer materials, and each material can be further classified according to its properties and characteristics. At present, the composition of β-phase tricalcium phosphate-based bioceramic materials in non-metallic mater...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/50
Inventor 马云海范雪莹尚文博吕雪漫庄健佟金
Owner JILIN UNIV
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