Method for preparing naringenin ultrafine particle by using supercritical compressed fluid anti-solvent precipitation process

A technology of anti-solvent precipitation and compressed fluid, which is applied in organic chemistry, bulk chemical production, etc., can solve the problems of low bioavailability, poor oral absorption, slow dissolution rate, etc., and achieve low solvent residue, convenient operation, and high yield. high rate effect

Inactive Publication Date: 2015-05-27
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have shown that naringenin has low water solubility, low solubility in the gastroi...

Method used

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  • Method for preparing naringenin ultrafine particle by using supercritical compressed fluid anti-solvent precipitation process
  • Method for preparing naringenin ultrafine particle by using supercritical compressed fluid anti-solvent precipitation process

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Embodiment

[0022] figure 1 It is an equipment diagram for implementing the method of the present invention. The device mainly includes a carbon dioxide delivery system, a solution delivery system and an autoclave. The main implementation process is: check the airtightness of the system, open the top CO2 2 Open the inlet valve and start the heater of the crystallization kettle. After the inside and outside of the kettle reach the predetermined temperature, the CO in the cylinder 2 Through the low-temperature constant temperature tank and high-pressure pump, it is passed into the crystallization kettle from the top of the kettle. After the temperature and pressure in the kettle are stabilized, open the CO2 at the bottom of the kettle. 2 outlet valve, and adjust the trim valve to a predetermined volume flow. After the system is stable, the prepared solution is sprayed into the crystallization kettle from the top of the kettle through the nozzle by the high-pressure infusion pump at a cer...

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Abstract

The invention relates to a method for preparing solid naringenin and particularly relates to a method for preparing naringenin ultrafine particle by using a supercritical compressed fluid anti-solvent precipitation process, so as to produce the naringenin ultrafine particle with an improved dissolution rate. By regulating pressure, temperature, solution concentration, CO2 flow rate and the like, the particle size of the naringenin ultrafine particle can be controlled effectively; the particle size of the prepared naringenin ultrafine particle is in a range of 0.5mu m to 6mu m and the product yield is above 85%. The accumulative release rate of the prepared naringenin ultrafine particle within 240min is increased by 3.2 times in comparison with that of a naringenin raw material.

Description

technical field [0001] The invention relates to a method for preparing naringenin ultrafine particles, in particular, the present invention relates to a method for preparing naringenin ultrafine particles using supercritical compressed fluid anti-solvent precipitation method (PCA), which is used to produce pomelo with improved Ultrafine particles for corticosteroid dissolution. technical background [0002] One of the ways to improve the dissolution rate of poorly soluble drugs is to increase the total surface area of ​​the particles by reducing the drug particle size. The particle size reduction techniques include spray drying, antisolvent method, jet milling, grinding, freeze drying, liquid antisolvent crystallization and supercritical fluid precipitation. Compared with other technologies, supercritical fluid technology, which has developed rapidly in recent years, has attracted great attention. This technology has many advantages such as: controllable particle size and p...

Claims

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Application Information

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IPC IPC(8): C07D311/32
CPCC07D311/32Y02P20/54
Inventor 王志祥缪虹刚颜庭轩黄德春程月
Owner CHINA PHARM UNIV
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