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Ultrasonic coupling agent and preparation method thereof

An ultrasonic couplant and solubilizer technology, applied in the field of couplant, can solve the problems of high component cost, product viscosity drop, complex components, etc., and achieve large-scale production, simple materials and components, and excellent sound-conducting performance Effect

Inactive Publication Date: 2015-06-03
QINGDAO MINGYAOTANG MEDICAL TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. Most of the existing disinfection and sterilization ultrasonic coupling agents are based on the original coupling agent formula, such as hydroxyethyl cellulose, chitosan, glycerol, carbomer, ethanol, sodium hydroxide, etc. Bacterial components, but because the compatibility between the bactericide and the water-based polymer gel cannot be well solved, the disinfection and sterilization products will appear crystallization, whitening, etc., which will affect the quality and use effect of the product;
[0006] 2. Most medical disinfection couplants need to undergo subsequent sterilization treatment, such as cobalt 60 sterilization treatment. If the irradiation time of cobalt 60 is not properly controlled, it will not only affect the appearance of the couplant product, but also cause the product to appear viscosity drop, discoloration, etc. There is a great quality risk;
[0007] 3. The components used in the coupling agent are relatively complex and the cost of the components is relatively high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A medical ultrasonic coupling agent for disinfection and sterilization, which is composed of six components including triclosan, F3 solubilizer, glycerin, carbomer, triethanolamine and purified water. The specific composition weight percentage is: 0.03% triclosan Health and 1.00% F3 solubilizer, 3.00% glycerol, 43.67% Carbomer 940, 21.83% triethanolamine, 30.47% purified water.

[0027] 1. The preparation method comprises the following steps:

[0028] 1) Slowly add carbomer into purified water, stir until completely dissolved and swollen, and leave it;

[0029] 2) Add F3 solubilizer to triclosan, stir until it is completely dissolved, then add glycerol and stir until uniform, record it as the oil phase, and leave it in place;

[0030] 3) Add triethanolamine to the oil phase of step 2), stir evenly, and leave in place;

[0031] 4) Mix the mixed solution prepared in steps 1) and 3) evenly, and leave in place;

[0032] 5) Vacuumize to obtain a transparent, bubble-free g...

Embodiment 2

[0035] A medical ultrasonic coupling agent for disinfection and sterilization, which is composed of six components including triclosan, F3 solubilizer, glycerin, carbomer, triethanolamine and purified water. The specific composition weight percentage is: 0.20% trichloro Health and 1.30% F3 solubilizer, 3.00% glycerol, 43.67% Carbomer 940, 21.83% triethanolamine, 30.00% purified water.

[0036] 1. The preparation method comprises the following steps:

[0037] 1) Slowly add carbomer into purified water, stir until completely dissolved and swollen, and leave it;

[0038] 2) Add F3 solubilizer to triclosan, stir until it is completely dissolved, then add glycerol and stir until uniform, record it as the oil phase, and leave it in place;

[0039] 3) Add triethanolamine to the oil phase of step 2), stir evenly, and leave in place;

[0040] 4) Mix the mixed solution prepared in steps 1) and 3) evenly, and leave in place;

[0041] 5) Vacuumize to obtain a transparent, bubble-free g...

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PUM

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Abstract

The invention relates to an ultrasonic coupling agent and a preparation method thereof. The ultrasonic coupling agent comprises the following raw materials: triclosan, an F3 solubilizer, glycerin, carbomer, triethanolamine and purified water. The ultrasonic coupling agent is colorless and transparent, does not contain an air bubble or contains a few of air bubbles, is moderate in viscosity, is capable of rapidly killing a plurality of pathogenic organisms, such as germs, viruses and bacteria, and is free of cytotoxicity on skin, free of thrill, free of sensitization, excellent in sound-conducting property and clear in ultrasonic image. The formula and the technological processes are adopted; the used material components are simple; the preparation technology is simple and convenient; and large-scale production can be realized.

Description

technical field [0001] The invention relates to a coupling agent, in particular to an ultrasonic coupling agent and a preparation method thereof. Background technique [0002] Medical ultrasonic couplant is used as an intermediary for transmitting sound waves. In the process of ultrasonic diagnosis and treatment, in order to improve the transmission of medical ultrasonic waves and make the image clear, first, the couplant must exclude the air between the probe and the skin; No skin damage, no cytotoxicity, no sensitization, no pollution. [0003] According to China's national conditions, it is impossible to use the ultrasound probe as a disposable product. Therefore, in order to reduce medical expenses, ultrasonic probes in ultrasonic diagnosis are usually directly used for detection and treatment of different patients or parts after simple wiping, which is very prone to cross-infection, especially cross-infection in cavity mucosal ultrasonic detection. At present, a condo...

Claims

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Application Information

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IPC IPC(8): A61K49/22
Inventor 李育强侯风君智倩倩刘红梅韩超
Owner QINGDAO MINGYAOTANG MEDICAL TECH DEV
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