Anti-tuberculous traditional Chinese medicine fritillary and burdock fruit tuberculosis-eliminating extractive and application

A technology for eliminating nuclei and extracts from scallops, applied in antibacterial drugs, pharmaceutical formulations, plant raw materials, etc., can solve the problems of difficult release of active ingredients, poor patient compliance, and general improvement effect, and achieves spleen tissue bacteria count. Effects of reduction, weight gain, and improved compliance

Inactive Publication Date: 2015-06-10
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The Chinese invention patent with the patent number 200710048778.X has the following disadvantages: first, because the invention patent is only to clean each Chinese herbal medicine, air-dry, pulverize, then mix and package, resulting in large dosage and poor patient compliance ; secondly, some active ingredients are not easy to release in the gastrointestinal tract; thirdly, although the Chinese medicinal materials

Method used

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  • Anti-tuberculous traditional Chinese medicine fritillary and burdock fruit tuberculosis-eliminating extractive and application
  • Anti-tuberculous traditional Chinese medicine fritillary and burdock fruit tuberculosis-eliminating extractive and application
  • Anti-tuberculous traditional Chinese medicine fritillary and burdock fruit tuberculosis-eliminating extractive and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1: Preparation of Niubei Xiaohe No. Ⅱ (alcoholic water extract)

[0070] (1) API compatibility:

[0071] Houttuynia cordata 800g, Bellflower 800g, Chuan Fritillaria 800g, Baiji 1700g, Burdock 800g, Glutinous rice 1100g;

[0072] (2) Alcohol extraction

[0073] Weigh 800g of Houttuynia cordata, 800g of Platycodon grandiflorum, and 800g of Fritillaria chinensis, put them into a container, add 50% ethanol with a concentration of 8 times the total weight of medicinal materials, soak for 30 minutes, heat to reflux, extract for 1.5 hours, and filter while hot to obtain Filtrate and filter residue, filter residue plus 50% ethanol with a concentration of 6 times the total weight of medicinal materials, heat to reflux, extract for 1 hour, filter while hot to obtain filtrate and filter residue, combine 2 filtrates, recover ethanol under reduced pressure and concentrate to obtain alcohol extraction thick paste, spare;

[0074] (3) Water extraction

[0075] According to...

Embodiment 2

[0078] Embodiment 2: the preparation of alcohol water extract

[0079] (1) API compatibility:

[0080] Houttuynia cordata 800g, Bellflower 800g, Chuan Fritillaria 800g, Baiji 1700g, Burdock 800g, Glutinous rice 1100g;

[0081] (2) Alcohol extraction

[0082] Weigh 800g of Houttuynia cordata, 800g of Platycodon grandiflorum, and 800g of Fritillaria chinensis, put them into a container, add 50% ethanol with a concentration of 8 times the total weight of medicinal materials, soak for 30 minutes, heat to reflux, extract for 1.5 hours, and filter while hot to obtain Filtrate and filter residue, the filtrate is decompressed to recover ethanol and concentrated to obtain a thick paste for alcohol extraction, which is set aside;

[0083] (3) Water extraction

[0084] According to the formula described in step (1), weigh Radix Radix Potatoes, Burdock Fructus and glutinous rice, mix with the filter residue obtained in step (2), add water 10 times the total weight of medicinal material...

Embodiment 3

[0087] Example 3 (secondary extraction): Preparation of Niubei Xiaohe No. Ⅲ (water extract)

[0088] (1) API compatibility:

[0089] Chuan Fritillaria 800g, Bellflower 800g, Baiji 1700g, Arctium 800g, Houttuynia cordata 800g, Glutinous rice 1100;

[0090] (2) Water extraction:

[0091] According to the formula described in step (1), weigh the crude drug, put it into a container, add water 10 times the total weight of the medicinal material, soak for 0.5 hours, heat and boil (keep slightly boiling), extract, filter, and obtain the filtrate and filter residue; Add water 10 times the total weight of the medicinal materials to the filter residue, soak for 0.5 hours, heat and boil (keep slightly boiling), extract, filter to obtain the filtrate and filter residue; combine the filtrate twice to obtain the water extract;

[0092] (3) Preparation of extract

[0093] The water extract obtained in step (2) is concentrated under reduced pressure to form a thick paste, dried under reduced...

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Abstract

The invention relates to an anti-tuberculous traditional Chinese medicine fritillary and burdock fruit tuberculosis-eliminating extractive and application and belongs to the field of traditional Chinese medicine treatment preparations. Alcohol water, water and/or alcohol are adopted to extract three extractives, adopted raw medicinal materials include, by weight, 3-5 parts of burdock fruits, 5-10 parts of common bletilla pseudobulb, 3-5 parts of fritillary fruits, 3-5 parts of platycodon grandiflorum, 3-10 parts of sticky rice and 3-5 parts of houttuynia cordata and are weighed in proportion, ethyl alcohol and/or water are/is added into the raw medicinal materials, heating is performed for reflux extraction after soaking, filtration is performed to obtain an extracting solution, pressure reduction is performed to recover a solvent, the solvent is concentrated to form thick paste, pressure-reduction drying is performed to form dry paste, and the dry paste is smashed and screened to obtain the extractive. The fritillary and burdock fruit tuberculosis-eliminating extractive serves as a traditional Chinese medicine treatment preparation and enables the weight of a mouse to be inordinately increased than the weight before the mouse is treated, and the weight is more than the weight increased by means of existing medicine powder combinations. Bacterial quantity of the spleen tissues can be remarkably decreased, the lung lesions are inordinately relieved, and a normal lung structure can be seen. The fritillary and burdock fruit tuberculosis-eliminating extractive is better than existing medicine powder in overall treatment effect and can be used for preparation of medicines for treating tuberculosis of patients.

Description

technical field [0001] The invention relates to an anti-tuberculosis traditional Chinese medicine Niubei Xiaonuo extract and its preparation and application, in particular to three Chinese medicine Niubei Xiaonuo extracts for antibacterial, especially anti-tuberculosis, and their preparation and application, belonging to the field of traditional Chinese medicine treatment preparations. Background technique [0002] Tuberculosis (TB) is a serious respiratory infectious disease caused by Mycobacterium tuberculosis (MTB). Although the number of tuberculosis patients worldwide has decreased, the number of patients with multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) continues to increase. According to the 2013 WHO Global Tuberculosis Report: In 2012, there were 8.7 million new tuberculosis patients worldwide and 1.3 million tuberculosis patients died of it. MDR-TB cases rose in 27 high MDR-TB burden countries, with 450 000 MDR-TB a...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P31/06
Inventor 吴雪琼刘光陵梁艳阳幼荣张俊仙白雪娟陈实兵刘军杨春玮罗华锋
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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