The invention discloses brain-strengthening bread by utilizing green beans and chayote and a preparation method thereof. The brain-strengthening bread comprises following raw material: 2-3 parts by weight of green beans, 1-2 parts by weight of agrocybe cylindracea, 6-8 parts by weight of beer, 0.5-1 part by weight of Kuding tea, 0.5-1 part by weight of longan, 0.5-1 part by weight of salvia miltiorrhiza, 100-110 parts by weight of flour, 20-25 parts by weight of chayote, 0.05-0.06 part by weight of xanthan gum, 1-1.1 parts by weight of arabic gum, 6-7 parts by weight of white granulated sugar, 0.8-0.9 part by weight of salt, 1.5-1.7 parts by weight of dried yeast, 2-3 parts by weight of waxy corn starch, 2-3 parts by weight of soy proteins, 5-6 parts by weight of shortening oil, 6-7 parts by weight of eggs, 4-5 parts by weight of whole milk powder, and a proper amount of ascorbic acid solutions, raisin fermentation broths, filtered juice in fermented glutinous rice fermented for 36 h, salad oil and water.The brain-strengthening bread by utilizing green beans and chayote and the preparation method thereof have following beneficial effects: by putting green beans into beer for sealed immersion and taking out of green beans, green beans taste like beer due to sealed immersion in beer and combined with agrocybe cylindracea so that the bread is rich in nutrition and perfectly matched.