Method for preparing compound pseudo-ginseng film coated tablet

A technology of compound notoginseng and film-coated tablets, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problem that the content of active ingredients cannot meet the minimum requirements of the standard and the disintegration of sugar-coated tablets The time limit exceeds the limit, sugar-coated tablets are easy to absorb moisture, etc., to achieve the effects of saving coating materials, accelerating release and absorption speed, and easy disintegration

Inactive Publication Date: 2015-02-25
CHENGDU SENKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing preparation method of compound notoginseng film-coated tablets needs to prepare dry cream powder and notoginseng fine powder respectively first, then add appropriate amount of auxiliary materials to the dry cream powder and notoginseng fine powder to mix and evenly granulate, and finally add volatile oil ethanol Solution or volatile oil cyclodextrin inclusion compound and appropriate amount of auxiliary materials are mixed, tableted, coated, etc. and the dry cream powder also includes 1/2 of the prescription amount, and the preparation of dry cream powder itself is a very complicated process. The process requires crushing various raw materials first, then cooking, spray drying, etc.
It can be seen that the preparation process of t...

Method used

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  • Method for preparing compound pseudo-ginseng film coated tablet
  • Method for preparing compound pseudo-ginseng film coated tablet
  • Method for preparing compound pseudo-ginseng film coated tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment one (compound notoginseng tablet prepared by film coating provided by the invention)

[0036] Raw materials include: Panax notoginseng 45.57Kg, Angelica dahurica 10.63Kg, Wood beetle 10.63Kg, Ligusticum chuanxiong 10.63Kg, Angelica 10.63Kg, Safflower 10.63Kg, Frankincense 10.63Kg, Myrrh 10.63Kg; Excipients include: Magnesium stearate 4.8Kg, Sodium carboxymethylcellulose (CMC) 0.72Kg; film coating powder 12Kg.

[0037] The steps of preparing the compound Sanqi film-coated tablet by adopting the above-mentioned crude drug, auxiliary material and film-coating powder are as follows in sequence:

[0038] (1) Pulverization: According to the above formula, take the processed medicinal materials of the 8 raw materials and put them in a microwave drying sterilizer for drying and sterilization at 70° C. until the water content is ≤4.0%, take them out, pulverize them into fine powders, and 80-mesh sieve, put into a double-layer clean plastic bag, and attach a material ...

Embodiment 2

[0049] Embodiment two (compound notoginseng tablet of traditional craft bag sugar coating)

[0050] The raw materials include: Panax notoginseng 45.57Kg, Angelica dahurica 10.63Kg, wood beetle 10.63Kg, Chuanxiong 10.63Kg, angelica 10.63Kg, safflower 10.63Kg, frankincense 10.63Kg, myrrh 10.63Kg.

[0051] (1) Pulverization: According to the above formula, the processed medicinal materials of the 8 herbs are respectively pulverized into fine powder, passed through an 80-mesh sieve, and attached with a material stick.

[0052] (2) Granulation: Add the extract powder into the mixer and mix evenly, add water and stir for 10 minutes to obtain soft material; put the soft material into the granulator to granulate; use 12 mesh iron screen to make the wet granules, mix the wet The particles are transferred to a hot air oven and dried at 115°C until the water content is less than 7%.

[0053] (3) Tablet compression: Use a 9 mm diameter deep arc die to compress the granules into tablets i...

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Abstract

The invention discloses a method for preparing a compound pseudo-ginseng film coated tablet. The method comprises steps of grinding, granulating, tabletting, coating and the like. According to the preparation method, the number of bacteria, mould, escherichia coli and other pathogenic bacteria in a product can be greatly reduced, moisture in medicinal materials can be reduced, and the medicinal materials can be easily ground; the content of ginsenoside in each compound pseudo-ginseng film coated tablet can be increased, and the product quality and acting effect on a focus can be improved; the tablet can be easily disintegrated in stomach and intestines, so that the releasing speed of the medicinal materials can be increased, the tablet can be absorbed in time to reach the level of plasma concentration after a patient takes the tablet, and the curative effect can be improved; coating materials can be reduced, and cost can be reduced; the tablet can be directionally absorbed by a human body; the labor production rate can be improved, and the labor intensity of workers can be reduced; and the preparation process can be simplified, potential consumption of raw materials can be eliminated, and industrialization can be easily realized.

Description

technical field [0001] The invention belongs to the technical field of Chinese patent medicines, and relates to a preparation method of Chinese patent medicines, in particular to a preparation method of compound notoginseng film-coated tablets. Background technique [0002] Compound Panax notoginseng film-coated tablets have the effects of removing blood stasis, stopping bleeding, reducing swelling and relieving pain, and are mainly used for bruises, blood stasis, swelling and pain, traumatic bleeding, contusions, sprains, and femoral trauma. However, the existing preparation method of compound notoginseng film-coated tablets needs to prepare dry cream powder and notoginseng fine powder respectively first, then add appropriate amount of auxiliary materials to the dry cream powder and notoginseng fine powder to mix and evenly granulate, and finally add volatile oil ethanol Solution or volatile oil cyclodextrin inclusion compound and appropriate amount of auxiliary materials a...

Claims

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Application Information

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IPC IPC(8): A61K36/286A61K9/30A61K47/40A61P29/00A61P7/04
CPCA61K9/2806A61K36/232A61K36/236A61K36/258A61K36/286A61K36/324A61K36/328A61K47/6951A61K2300/00Y02A50/30
Inventor 晏柳清田兴华李万荣罗丹
Owner CHENGDU SENKE PHARMA
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