Pteris semipinnata general flavone sustained release preparation and preparation method thereof

A technology of sustained-release preparations and total flavonoids, which is applied in pharmaceutical formulations, medical raw materials derived from ferns/filamentous plants, drug delivery, etc., can solve life-threatening problems, achieve balanced and lasting curative effect, and overcome frequent medication , the effect of enhancing compliance

Inactive Publication Date: 2015-06-24
广西南宁科冠医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, when cancer pain occurs, the patient is extremely painful, and if not treated in time, it may even be life-threatening. This requires the development of new sustained

Method used

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  • Pteris semipinnata general flavone sustained release preparation and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Respectively, the total flavonoids of Banner Banner, carboxypropyl cellulose K1001v, microcrystalline cellulose and magnesium stearate are fully dried and passed through a 100-mesh sieve for subsequent use; take 8 g of Banner Banner total flavonoids, add 13.5 g of carboxypropyl methylcellulose K1001v and 8.2g microcrystalline cellulose, mix well, add 5.94ml of 90% ethanol to prepare soft material, granulate with 20 mesh sieve, dry at 60°C, then granulate with 24 mesh sieve, add 0.3g magnesium stearate and mix evenly, 100 sustained-release tablets were prepared by a tablet machine.

Embodiment 2

[0025] Respectively fully dry the total flavonoids of Banner Banner, carboxypropyl cellulose K4M, microcrystalline cellulose, sodium carboxymethyl cellulose, and magnesium stearate, pass through a 100-mesh sieve, and set aside; take 8g of total flavonoids of Banner Banner, add 12.0g Carmellose K4M, 8.2g of microcrystalline cellulose and 1.5g of sodium carboxymethylcellulose were mixed uniformly, and 5.94ml of 90% ethanol was added to prepare a soft material, granulated with a 20-mesh sieve, dried at 60°C, and then dried at 24 Mesh sieve for granulation, add 0.3g of magnesium stearate and mix evenly, prepare 100 sustained-release tablets through a tablet machine.

Embodiment 3

[0027] Fully dry the total flavonoids, carboxypropyl cellulose K4M, microcrystalline cellulose, and magnesium stearate respectively and pass through a 100-mesh sieve for later use; take 7.6 g of the total flavonoids of the half-pinner, add 12.0 g of carboxypropyl methylcellulose K4M 10.1g microcrystalline cellulose, mix well, add 5.94ml of 90% ethanol to prepare soft material, granulate with 20 mesh sieve, dry at 60°C, then granulate with 24 mesh sieve, add 0.3g magnesium stearate and mix evenly , prepare 100 sustained-release tablets through a tablet machine.

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Abstract

The invention discloses a pteris semipinnata general flavone sustained release preparation and a preparation method thereof and belongs to the technical field of traditional Chinese medicine preparation. The pteris semipinnata general flavone sustained release preparation is prepared from the following components by weight percentage: 7.2-16.0% of pteris semipinnata general flavone, 0.8-4.0% of disintegrating agent, 25.0-35.0% of filler A, 18.0-33.0% of sustained release material, and 10.0-35.0% of filler B. The medicine is released in the medication later period, the pesticide effect is smooth and durable, the shortcomings of frequent medication times and large blood concentration fluctuation in the common preparation are overcome and thus the long-term medication is facilitated. The in vitro release test shows that the release rates of the pteris semipinnata general flavone sustained release preparation in 2h, 6h and 10h are respectively 25-45%, 45-75% and greater than 85% of the labelled amount, and the release rate in 12h is close to 90%; the pteris semipinnata general flavone sustained release preparation has an obvious sustained release effect and the pesticide effect is smooth and durable.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a slow-release preparation of half-banner total flavonoids and a preparation method thereof. Background technique [0002] Half-side flag Pteris semipinnata L., also known as half-side fern, lobelia, and single-side flag, is a plant of Pteridaceae. It is a commonly used herbal medicine in the south. The plant has the effects of hemostasis, muscle growth, detoxification, and swelling. It is used in the folks to treat hematemesis, traumatic bleeding, back hair, sores, bruises, red eyes, swelling and pain. Modern research shows that half-side flag contains various substances such as volatile oil, terpenes, flavonoids, saponins and so on. The research on the medicinal components of Banner Banner mainly focuses on terpenoids, and the research reports on flavonoids in Banner Banner are less. [0003] Flavonoids are an important class of medicinal ing...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61K9/22
Inventor 杨建国梁梦雪
Owner 广西南宁科冠医药科技开发有限公司
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