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Preparation method of ambroxol hydrochloride nanoparticles

A technology of ambroxol hydrochloride and nanoparticles, which is applied in the field of preparation of ambroxol hydrochloride nanoparticles, and achieves the effects of low production cost, rapid hydrolysis and strong stability

Inactive Publication Date: 2015-07-01
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A kind of ambroxol hydrochloride nanoparticle of the present invention aims to overcome the deficiencies in the clinical application of ambroxol hydrochloride tablets and granules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] Ambroxol hydrochloride nanoparticles were prepared by emulsion polymerization with n-butyl cyanoacrylate as capsule material.

[0027] First, use 10ml of n-butyl polycyanoacrylate in an appropriate amount of ethanol and set aside. Then, accurately measure 50ml of 7.5mg / ml ambroxol hydrochloride solution, add 0.2-2.0g of surfactant Pluronic F-68, 0.2-2.0g of dextran-70, 1-10g of sodium sulfite, and adjust the pH value with hydrochloric acid To 1.0-3.0, spare. Finally, slowly add (1) to (2) under the condition of 50-300r / min, continue to stir for 1-6h, then adjust the pH value to neutral with sodium hydroxide solution, continue to stir for 1-3h, 0.45μm Filter through a microporous membrane to obtain a milky white suspension of ambroxol hydrochloride nanoparticles.

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Abstract

The invention discloses a preparation method of ambroxol hydrochloride nanoparticles. Main components for preparing the ambroxol hydrochloride nanoparticles comprise 1-90wt% of ambroxol hydrochloride and 1-30wt% of poly(n-butylcyanoacrylate. The preparation method of the ambroxol hydrochloride nanoparticles has the advantages of simplicity and few medicinal auxiliary materials, and the above medicinal preparation has the advantages of good stability, definite therapeutic effect and high bioavailability, and is a good medicine for treating acute and chronic respiratory diseases.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a preparation method of ambroxol hydrochloride nanoparticles. Background technique [0002] Ambroxol hydrochloride is a unique new expectorant drug, and its expectorant effect is stronger than that of bromhexine. This product has the functions of dissolving mucus, promoting the synthesis of pulmonary surfactant and activating the purification function of mucus and cilia. It also has the effect of reducing the adhesion between sputum and cilia and making sputum easy to cough up. Ambroxol hydrochloride Ambroxol HCl has been proved in clinical trials: this product can regulate the secretion of serous and mucus, promote the synthesis of pulmonary surfactant, strengthen the vibration of cilia, and increase the clearance capacity of the mucociliary transport system. This product can also increase the volume of respiratory tract fluid, reduce mucus secretion, promote the secr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/137A61K47/32A61P11/10
Inventor 曾培安曾灿丽吴健民刘娟贺莲张静
Owner KAMP PHARMA