Acanthopanax senticosus extract, preparation method and preparation thereof

An Acanthopanax extract and Acanthopanax technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of poor removal of impurities, unstable extract preparation, easy oxidation and decomposition, etc., to alleviate Burden, huge application prospect and market value, effect of improving purity

Inactive Publication Date: 2015-07-01
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is suitable for decolorization treatment, and the effect on removing impurities is relatively poor, and a certain content loss occurs during the decolorization process
[0008] Most of the researches on Acanthopanax senticosus are to remove a large number of unstable mac

Method used

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  • Acanthopanax senticosus extract, preparation method and preparation thereof
  • Acanthopanax senticosus extract, preparation method and preparation thereof
  • Acanthopanax senticosus extract, preparation method and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: Preparation of Acanthopanax Acanthopanax Extract

[0064] (1) Extraction: extract Acanthopanax senticosus medicinal material (8kg) with 6 times the amount of water (48L) for 3 times, extract for 1 hour each time, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction, and set aside;

[0065] (2) One-time alcohol precipitation: under stirring conditions, slowly add 95% ethanol (to make the alcohol content reach 75%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, and let it stand for 6 hours; filter , the filtrate recovers ethanol until it has no alcohol smell, and continues to concentrate to a relative density of 1.18 (measured at 80°C), to obtain a primary alcohol precipitation paste of Acanthopanax acanthopanax extract, which is ready for use;

[0066] (3) Lithium sulfur method: take the Acanthopanax senticosus extract obtained in step (2) and add an appropriate amount of the primary alcohol ...

Embodiment 2

[0070] Embodiment 2: Preparation of Acanthopanax Acanthopanax Extract

[0071] (1) Extraction: extract Acanthopanax senticosus medicinal material (6kg) twice with 8 times the volume of water (48L), extract for 2 hours each time, combine the extracts, concentrate to obtain Acanthopanax senticosus water decoction, and set aside;

[0072] (2) Primary alcohol precipitation: under stirring conditions, slowly add 93% ethanol (to make the alcohol content reach 74.5%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, and let stand for 12 hours; filter , the filtrate recovers ethanol until it has no alcohol smell, and continues to concentrate to a relative density of 1.16 (measured at 80°C), to obtain a primary alcohol-precipitated paste of Acanthopanax acanthopanax extract, which is ready for use;

[0073] (3) Lithium sulfur method: Take the Acanthopanax senticosus extract obtained in step (2) and add an appropriate amount of the primary alcohol precipita...

Embodiment 3

[0077] Example 3: Preparation of Acanthopanax Acanthopanax Extract

[0078] (1) Extraction: extract Acanthopanax senticosus medicinal material (10kg) twice with 12 times the volume of water (120L), extract for 1.5 hours each time, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction, which is set aside;

[0079] (2) One-time alcohol precipitation: under stirring conditions, slowly add 95% ethanol (to make the alcohol content reach 75.5%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, and let it stand for 18 hours; filter , the filtrate recovers ethanol until it has no alcohol smell, and continues to concentrate to a relative density of 1.14 (measured at 80°C), to obtain a primary alcohol precipitation paste of Acanthopanax acanthopanax extract, which is ready for use;

[0080] (3) Lithium sulfur method: Take the Acanthopanax senticosus extract obtained in step (2) and add an appropriate amount of the primary alc...

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Abstract

The invention relates to a preparation method for an acanthopanax senticosus extract, the acanthopanax senticosus extract prepared by the method and a preparation containing the acanthopanax senticosus extract. The method includes: extracting an acanthopanax senticosus extract medicinal material with water, concentrating the extracted solution to obtain an acanthopanax senticosus water decoction paste; carrying out primary alcohol precipitation and concentration to obtain primary alcohol precipitation paste; adjusting the pH with lime milk and sulfuric acid, and then conducting standing and concentration to obtain a concentrated paste; then performing secondary alcohol precipitation and concentration to obtain secondary alcohol precipitation paste; diluting the secondary alcohol precipitation paste, then carrying out macroporous adsorbent resin adsorption and elution, subjecting the eluent to secondary ultrafiltration, and then conducting concentration to obtain the acanthopanax senticosus extract. The method provided by the invention can significantly reduce the content of impurities, especially nonpolar invalid impurities in the acanthopanax senticosus extract, improve the purity of effective components in the acanthopanax senticosus extract and the safety and stability of the extract, also reduces the energy consumption and greatly improves the extract yield, thus having huge application prospects and market value.

Description

technical field [0001] The present invention relates to the field of medicinal plant extraction, in particular to a preparation method of Acanthopanax senticosus extract, and the Acanthopanax senticosus extract obtained by the preparation method and a preparation containing the Acanthopanax senticosus extract. Background technique [0002] Acanthopanax is the dry root and rhizome or stem of Acanthopanax senticosus (Rupr. et Maxim.) Harms, a plant of Araliaceae. It has the effects of invigorating qi, invigorating the spleen, invigorating the kidney and calming the nerves. Sexually pungent, slightly bitter, warm. It is used for spleen and lung qi deficiency, physical weakness and fatigue, loss of appetite, lung and kidney deficiency, chronic cough and shortness of breath, kidney deficiency, waist and knee pain, insufficiency of heart and spleen, insomnia and dreaminess. [0003] The main active ingredients in Acanthopanax are flavonoids, saponins and polysaccharides, and the...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61P1/00A61P13/12A61P25/20
Inventor 方同华许照芹刘玉成陈景超曾向东席桂才
Owner HARBIN ZHENBAO PHARMA
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