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Acanthopanax senticosus extract, preparation method thereof and preparation containing the same

A technique for extracts of Acanthopanax senticosus and Acanthopanax senticosus, applied in the directions of anti-inflammatory agents, drug combinations, pharmaceutical formulations, etc., can solve the problems of poor removal of impurities, unstable extract preparations, easy oxidative decomposition, etc. Yield improvement, huge application prospect and market value, the effect of improving purity

Inactive Publication Date: 2015-07-01
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is suitable for decolorization treatment, and the effect on removing impurities is relatively poor, and a certain content loss occurs during the decolorization process
[0009] Most of the researches on Acanthopanax senticosus are to remove a large number of unstable macromolecular compounds in the extract, such as tannins, resins, pigments, etc., and these macromolecular compounds are easy to be oxidized and decomposed, which is also the reason why the Acanthopanax senticosus extract and One of the reasons for the instability of its preparation

Method used

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  • Acanthopanax senticosus extract, preparation method thereof and preparation containing the same
  • Acanthopanax senticosus extract, preparation method thereof and preparation containing the same
  • Acanthopanax senticosus extract, preparation method thereof and preparation containing the same

Examples

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Effect test

Embodiment 1

[0065] Embodiment 1: Preparation of Acanthopanax Acanthopanax Extract

[0066] (1) Extraction: extract Acanthopanax senticosus medicinal material (8kg) with 6 times the volume of water (48L) for 3 times, extract for 1 hour each time, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction, which is set aside;

[0067] (2) Alcohol precipitation: under stirring conditions, slowly add 95% ethanol (to make the alcohol content reach 75%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, let stand for 6 hours, filter, Recover ethanol from the filtrate until it has no alcohol smell, continue to concentrate until the relative density is 1.17 (measured at 80°C), and obtain the alcohol-precipitated paste of Acanthopanax senticosus extract, which is set aside;

[0068] (3) Lithium sulfur treatment: take an appropriate amount of the ethanol extract of Acanthopanax senticosus obtained in step (2) and add it to a tank filled with a...

Embodiment 2

[0072] Embodiment 2: Preparation of Acanthopanax Acanthopanax Extract

[0073] (1) Extraction: extract Acanthopanax senticosus medicinal material (6kg) with 8 times the volume of water (48L) for 2 times, each time for 2 hours, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction for future use;

[0074] (2) Alcohol precipitation: under stirring conditions, slowly add 93% ethanol (to make the alcohol content reach 74.5%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, and let stand for 12 hours; filter, Recover the ethanol from the filtrate until it has no alcohol smell, continue to concentrate until the relative density is 1.18 (measured at 80°C), and obtain the alcohol-precipitated paste of Acanthopanax acanthopanax extract, which is set aside;

[0075] (3) Lithium sulfur treatment: take an appropriate amount of the ethanol extract of Acanthopanax senticosus extract obtained in step (2) and add it to a tank fill...

Embodiment 3

[0079] Example 3: Preparation of Acanthopanax Acanthopanax Extract

[0080] (1) Extraction: extract Acanthopanax senticosus medicinal material (10kg) twice with 12 times the volume of water (120L), extract for 1.5 hours each time, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction, and set aside;

[0081] (2) Alcohol precipitation: under stirring conditions, slowly add 95% ethanol (to make the alcohol content reach 75.5%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, and let stand for 12 hours; filter, and the filtrate Recover ethanol until there is no alcohol smell, continue to concentrate until the relative density is 1.14 (measured at 80°C), and obtain the alcohol-precipitated paste of Acanthopanax acanthopanax extract, which is set aside;

[0082] (3) Lithium sulfur treatment: take an appropriate amount of the ethanol extract of Acanthopanax senticosus extract obtained in step (2) and add it to a tank fil...

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Abstract

The invention relates to a preparation method for an acanthopanax senticosus extract, the acanthopanax senticosus extract prepared by the method and a preparation containing the acanthopanax senticosus extract. The method includes: extracting an acanthopanax senticosus medicinal material with water, adding water to the obtained acanthopanax senticosus and conducting decoction and alcohol precipitation so as to obtain an acanthopanax senticosus extract alcohol precipitation paste; and treating the acanthopanax senticosus extract alcohol precipitation paste by a lime-sulphur technique, then carrying out adsorption and elution with macroporous resin and DM1180 resin in order, and subjecting the eluent to two-stage ultrafiltration, thus obtaining the acanthopanax senticosus extract. The method provided by the invention can significantly reduce the content of impurities, especially nonpolar invalid impurities in the acanthopanax senticosus extract, improve the purity of effective components in the acanthopanax senticosus extract and the safety and stability of the acanthopanax senticosus extract, at the same time can reduce energy consumption, and greatly enhances the extract yield, achieves a effect superior to the prior art, thus having enormous application prospects and market value.

Description

technical field [0001] The present invention relates to the field of medicinal plant extraction, in particular to a preparation method of Acanthopanax senticosus extract, and the Acanthopanax senticosus extract obtained by the preparation method and a preparation containing the Acanthopanax senticosus extract. Background technique [0002] Acanthopanax is the dry root and rhizome or stem of Acanthopanax senticosus (Rupr. et Maxim.) Harms, a plant of Araliaceae. It has the effects of invigorating qi, invigorating the spleen, invigorating the kidney and calming the nerves. Sexually pungent, slightly bitter, warm. It is used for spleen and lung qi deficiency, physical weakness and fatigue, loss of appetite, lung and kidney deficiency, chronic cough and shortness of breath, kidney deficiency, waist and knee pain, insufficiency of heart and spleen, insomnia and dreaminess. [0003] The main active ingredients in Acanthopanax are flavonoids, saponins and polysaccharides, and the...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61P1/14A61P11/14A61P11/06A61P25/20A61P29/00
Inventor 方同华许照芹刘玉成陈景超曾向东席桂才
Owner HARBIN ZHENBAO PHARMA
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