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Method for extracting chemical components from root of mongolian medicine Cymbaria dahurica
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A technology of chemical composition and bark root, which is applied in the field of natural product extraction and separation, to achieve the effect of simple process, low price and reduced raw material cost
Inactive Publication Date: 2015-07-08
INNER MONGOLIA UNIVERSITY
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However, at present, there is only one Hungarian literature report on the extraction and separation of effective chemical components of the Mongolian medicine Daurixinba, and no other literature reports have been seen.
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Embodiment 1
[0025] Implementation example 1, the extraction and separation of the chemical components of the Mongolian medicine Dawuli Simba root of the present invention
[0027] 1.1Kg of shade-dried Dauri sago root was ground into dry powder (moisture content lower than 0.5%, weight ratio), and refluxed with 5 times the amount of 95% ethanol at 75°C for three times, each time for six hours. The combined extracts were concentrated under reduced pressure to obtain about 180 g of brown-yellow extract.
[0028] (2) Extraction
[0029] Disperse the brown-yellow extract with 50% ethanol, then extract with petroleumether, ethyl acetate, and n-butanol respectively, and concentrate under reduced pressure to obtain petroleumether extract, ethyl acetate extract, and n-butanol extract respectively. matter, the quality is respectively 40g, 27g, 80g, and the extraction rate is respectively 3.6%, 2.5%, 7.3%.
[0030] (3) Separation and purification of petroleum eth...
Embodiment 2
[0039] Implementation example two, the structural identification of the effective chemical constituents of the Mongolian medicine Dawuli Simba root of the present invention
[0040] The identification results of 4 compounds and 1 mixture are as follows:
[0041] Compound 1: white solid, m.p: 64-65°C; IR(KBr)v max (em -1 ): 3069, 2955, 2918, 2872, 2850, 1704, 1472, 1311, 942, 719; 1 HNMR (600MHz, DMSO-d 6 ) (ppm): δ2.35 (2H, d, J = 9.5), 1.65 (2H, d, J = 7.5), 1.26 (24H, s), 0.90 (3H, d, J = 9.5), 13 CNMR (125MHz, DMSO-d 6 ) (ppm): 181.0, 34.5, 32.3, 30.1, 29.9, 29.8, 29.7, 29.5, 25.1, 23.1, 14.5. The NMR data were accurately assigned by DEPT, HSQC, and HMBC spectra, and the data showed that the compound was hexadecanoic acid, namely palmitic acid.
[0042] Compound 2: white powdery solid; easily soluble in chloroform; no spots were observed under UV light during TLC analysis; EI-MS (m / z): 303, 285, 253; 1 HNMR (600MHz, DMSO-d 6 )(ppm): 5.26(1H, m), 5.20(1H, dd, J=15.4,...
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Abstract
The invention belongs to the technical field of natural product extraction separation and relates to a method for extracting and separating four compounds and one mixture form the root of mongolian medicine Cymbaria dahurica. The method utilizes root of mongolian medicine Cymbaria dahurica as a raw material and comprises the following steps of 1, alcohol extraction, 2, extraction, 3, silicagel column- and polyamide column-based separation and purification of petroleumether extract, 4, silicagel column-based separation and purification of ethyl acetate extract, and 5, identification of the compounds 1-4 of palmitic acid, cholest-8 alpha-methoxy-22-double bond-3 beta, 6 beta-diol, luteolin and luteolin-7-O-beta-D-glucoside and the mixture 1 of a straight-chain alkane compound by modern spectral data. The method creatively utilizes mongolian medicine Cymbaria dahurica with a medicinal value as a raw material, realizes separation of five materials, has simple processes and a low comprehensive cost and lays a foundation of research of mongolian medicine Cymbaria dahurica.
Description
technical field [0001] The invention belongs to the technical field of extraction and separation of natural products, and specifically relates to the extraction and separation of chemical components from the root of the Mongolian medicine Dawuli siba - palmitic acid, cholesteryl-8α-methoxyl-22-double bond-3β, 6β-diol , luteolin, luteolin-7-O-β-D-glucoside and linear alkanes. Background technique [0002] Dawu Lixinba, also known as Dahuanghua, Baihaocao, Xing'an Xinba, belongs to Scrophulariaceae, Xinba genus, perennial herb. Xinba is a special medicine for Mongolian medicine, which is divided into two types: Dawuli Xinba and Mongolian Xinba. "Inner Mongolia Chinese Herbal Medicine" classifies Xinba as the hemostatic drug of blood-regulating drugs, and contains: "Xinba, slightly bitter taste, cool in nature. Dispelling rheumatism, diuresis, and hemostasis. Indications for rheumatoid arthritis, menorrhagia, vomiting blood, epistaxis blood, hematochezia, traumatic bleeding, ...
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