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Rhizoma bletillae fibrous root biphenanthryl D and preparation method and application thereof

A fibrous root and semi-preparation technology, applied in ether preparation, ether separation/purification, organic chemistry and other directions, can solve problems such as waste of resources, and achieve good bacteriostatic and anti-tumor effects.

Inactive Publication Date: 2015-07-22
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in the literature that the ratio of fibrous root to tuber yield of Baiji is as high as 1:4 to 1:3, that is, about 1 ton of fibrous root is discarded for every 3-4 tons of Baiji produced, which is a great waste of resources.

Method used

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  • Rhizoma bletillae fibrous root biphenanthryl D and preparation method and application thereof
  • Rhizoma bletillae fibrous root biphenanthryl D and preparation method and application thereof
  • Rhizoma bletillae fibrous root biphenanthryl D and preparation method and application thereof

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Embodiment 1

[0023] Put the sun-dried bletilla or tuber roots in an oven, dry at 35°C, crush them, and pass through a 40-mesh sieve to get bletilla powder; take 1.5kg of the powder and add 95% according to the material ratio 1: (5-10) Ethanol reflux extraction 4 times, 30-100min each time, filter, combine the filtrates, concentrate under reduced pressure to obtain 100-500g of extract; suspend the extract in water, and use equal volumes of ethyl acetate, water-saturated n-butanol in sequence Extracted 4 times, concentrated under reduced pressure to obtain ethyl acetate extract; the ethyl acetate extract was mixed with silica gel, the mass ratio of ethyl acetate extract: silica gel was 1:1, and the sample was loaded by dry method, chloroform: methanol (100:0, 80:1, 60:1, 40:1, 20:1, 5:1, 1:1, 0:1) gradient elution, the elution volume is 5 column volumes, and the chloroform is collected: Methanol = (20-60): 1 elution component, spotting on a thin-layer silica gel plate, combining spots with t...

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Abstract

The invention discloses new rhizoma bletillae fibrous root biphenanthryl D and a preparation method and an application thereof, and belongs to the technical field of traditional Chinese medicine. The rhizoma bletillae fibrous root biphenanthryl D has the structure represented by the formula 1. The preparation method comprises the steps: after reflux extraction by a 95% ethanol, extracting by using ethyl acetate, carrying out silica gel column chromatography of the ethyl acetate extract, carrying out gradient elution with chloroform:methanol, collecting an eluted component with chloroform:methanol=(20-60):1, carrying out sample application with a thin-layer silica gel plate, merging spots with the same RF value, and thus obtaining a merged material; repeatedly carrying out silica gel column chromatography on the merged material, carrying out high-performance liquid semi-preparation, and thus obtaining the rhizoma bletillae fibrous root biphenanthryl D. The rhizoma bletillae fibrous root biphenanthryl D has quite good antibacterial and anti-tumor effects and mainly exists in rhizoma bletillae fibrous roots, so as to provide an effective means for reasonable use of the rhizoma bletillae fibrous roots.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a novel bletilla baicalensis and fibrous root lianfei D and its preparation method and application. Background technique [0002] Bletilla sfriata (Thunb.) Reiehb.f. is the dried tuber of orchid plant Bletilla sfriata (Thunb.) Reiehb.f., which tastes bitter, sweet, astringent, slightly cold, and returns to the lung, stomach, and liver meridian. It is used for the treatment of hemoptysis, hematemesis, traumatic bleeding, sore swelling and chapped skin. Baiji is mainly produced in Guizhou, Sichuan, Yunnan, Hunan, Hubei, Anhui, Zhejiang and other provinces. Baiji has a long history of medicinal use and obvious medicinal value. Scholars at home and abroad have done a lot of research on its chemical composition and pharmacological activity. However, in the study of antibacterial activity, there are few researchers and they mainly study crude extracts...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C43/23C07C41/34A61P35/00A61P31/04
CPCC07C43/23C07C41/34
Inventor 程东庆丁志山蒋福升钱朝东沈勇丁滨陈铌铍余杭苏
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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