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Drug preparation and applications of drug preparation in preparation of myocardial ischemia and gastritis treating drugs

A technology of myocardial ischemia and drugs, applied in drug combinations, cardiovascular system diseases, pharmaceutical formulations, etc.

Inactive Publication Date: 2015-08-05
BEIJING FUANHUA BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017]Propantheline bromide, English name: Propantheline Bromide, alias: Propantheline, has M receptor blocking effect similar to "atropine", but it is harmful to stomach The selectivity of intestinal M receptors is high, and the effect of antispasmodic and inhibition of gastric acid secretion is strong and long-lasting

Method used

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  • Drug preparation and applications of drug preparation in preparation of myocardial ischemia and gastritis treating drugs
  • Drug preparation and applications of drug preparation in preparation of myocardial ischemia and gastritis treating drugs
  • Drug preparation and applications of drug preparation in preparation of myocardial ischemia and gastritis treating drugs

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the protective effect of propantheline bromide on myocardial ischemia in anesthetized dogs

[0031] 1 Materials and Instruments

[0032] TDZ5-4.0 multi-tube rack automatic balancing centrifuge (Hunan Instrument Factory), LG-E&H-20 dynamic erythrocyte sedimentation rate / pressure volume tester (Beijing Zhongqin Shidi Co., Ltd.), RM-6280 multi-channel intelligent physiological signal acquisition , Treatment system (Chengdu Instrument Factory and Japan NihonKohden Company), SC-3 electric ventilator (Zhejiang Medical University Instrument Factory).

[0033] Propantheline Bromide Tablets (Jiangsu Tasly Diyi Pharmaceutical Co., Ltd., approved by H32025089), Nitrendipine Tablets (Shanghai Xinyi Tianping Pharmaceutical Co., Ltd., approved by H31020349), sodium pentobarbital (Sinopharm Group Chemical Co., Ltd. Reagent Co., Ltd., WS20120401), CK and LDH kits (Nanjing Jiancheng Institute of Bioengineering). Healthy mixed-breed dogs, weighing 14-16 kg, ...

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PUM

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Abstract

The present invention relates to the technical field of chemical drugs and clinical diagnosis and treatment, specially to a drug preparation and applications of the drug preparation in preparation of myocardial ischemia and gastritis treating drugs, particularly to a propantheline bromide drug and applications of the propantheline bromide drug in preparation of drugs for treating myocardial ischemia, stomach ulcer, duodenal ulcer, gastritis, pancreatitis and enterospasm, wherein the propantheline bromide drug is propantheline bromide drug tablets and propantheline bromide drug capsules. According to the present invention, with the technology, the medical clinical uses are expanded, and the new medication selection and the clinical diagnosis and treatment scheme are provided for the treatments of myocardial ischemia, stomach ulcer, duodenal ulcer, gastritis, pancreatitis, enterospasm and other diseases.

Description

Technical field [0001] The present invention involves the field of chemical drugs and clinical diagnosis and treatment technology, and specially involves a new use of bromine and its pharmaceutical use. Background technique [0002] Myocardial ischemia is the initial stage of a variety of heart disease. Clinically, coronary heart disease is mainly manifested in myocardial ischemia such as angina pectoris and myocardial infarction.In recent years, with the widespread application of modern medical molecular biology, modern medicine has also had a deeper understanding of the pathophysiological process of ischemic heart disease.The research perspective of anti -myocardial ischemia mechanisms mainly include: inhibiting cell apoptosis, clearing free radicals, suppressing calcium overload, promoting new blood vessels, and inhibiting inflammation damage. [0003] 1. Inhibit the apoptosis [0004] Pitching is also called cell programming. The myocardial myocardial muscle apoptosis occurs ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P9/10A61P1/04A61P1/18A61P1/06
Inventor 吴平安黄金勇丁丽曼王莉
Owner BEIJING FUANHUA BIOLOGICAL TECH CO LTD