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A modified soybean protein hollow capsule material and its preparation method

A soy protein and hollow capsule technology, applied in the direction of capsule delivery, inactive components of polymer compounds, etc., can solve problems such as hardening and brittleness, drug moisture absorption failure, hindering drug release, etc., and achieve good film-forming performance and application potential. Huge, well-adapted effect

Active Publication Date: 2017-12-26
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, gelatin capsules also have certain limitations, which are mainly reflected in the following aspects: 1. The raw material gelatin is boiled from bones and skins of pigs, cattle, and sheep, and the use of animal source materials on the one hand Increased the potential safety hazards of capsules, especially the outbreak of mad cow disease in western countries, etc. has exacerbated people's concerns about the safety of gelatin capsules, and on the other hand, it has also caused people with special beliefs and vegetarians to be inedible; 2. The water content of gelatin capsules High hygroscopicity and strong hygroscopicity, it is easy to transfer moisture to the contents of the capsule, causing the drug to fail to absorb moisture or even be inedible; 3. The stability of gelatin capsules is greatly affected by temperature, and it becomes hard and brittle at low temperatures, which may easily cause capsule damage. Drug leakage, etc.; 4. Gelatin capsules are prone to cross-linking reactions with aldehyde-containing drugs, hindering drug release and prolonging the disintegration time limit
5. In recent years, the "poisonous capsule" incident has had a bad impact, aggravating people's concerns about the safety of pharmaceutical capsules, seriously reducing the credibility of the capsule market, and bringing haze to the field of pharmaceutical capsules
However, it is still impossible to realize the hot-melt process of edible soybean protein isolate and the modified substance that completely replaces gelatin

Method used

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  • A modified soybean protein hollow capsule material and its preparation method
  • A modified soybean protein hollow capsule material and its preparation method
  • A modified soybean protein hollow capsule material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-2

[0033] 1) Mix and dissolve soy protein isolate powder and distilled water at a ratio of 1:5, stir in a water bath at 60°C for 30 minutes under nitrogen protection, then raise the temperature to 70°C, react at constant temperature for 1.5 hours, and use 1.0mol / L sodium hydroxide The solution is adjusted to pH7, and the soybean protein isolate activation treatment is carried out;

[0034] 2) After the activation treatment, add the lactic acid prepolymer produced by the reaction, raise the temperature to 80°C, add the catalyst after the temperature is stable, evacuate to 100Pa, and react for 4 to 12 hours to form a water-insoluble copolymer product, remove the product, and wash repeatedly , and vacuum-dried to complete the graft modification of soybean protein isolate.

[0035] 3) each component and mass ratio:

[0036] Modified soybean protein: 85 parts;

[0037] κ-type carrageenan: 10 parts;

[0038] Polyethylene glycol: 2.0 parts;

[0039] Genipin: 2.0 parts;

[0040] Tea g...

Embodiment 3-5

[0046] 1) Soybean protein isolate powder and distilled water were mixed and dissolved at a ratio of 1:3, and stirred in a water bath at 60°C for 30 minutes under nitrogen protection. Then raise the temperature to 70°C, react at constant temperature for 2 hours, adjust the pH to 8 with 1.0mol / L sodium hydroxide solution, and perform the activation treatment of soybean protein isolate;

[0047] 2) After the activation treatment, add the lactic acid prepolymer produced by the reaction, raise the temperature to 80°C, add the catalyst after the temperature is stable, evacuate to 100Pa, and react for 4 to 12 hours to form a water-insoluble copolymer product, remove the product, and wash repeatedly , vacuum-dried to complete the graft modification of soybean protein isolate;

[0048] 3) each component and mass ratio:

[0049] Modified soybean protein: 65 parts;

[0050] Pectin and sodium alginate: 32 parts;

[0051] Sucrose vinegar: 1.0 parts;

[0052] Genipin: 1.0 parts;

[005...

Embodiment 6-8

[0056] 1) Mix and dissolve soybean protein isolate powder and distilled water at a ratio of 1:7, and stir for 30 minutes in a water bath at 60°C under nitrogen protection. Then raise the temperature to 90°C, react at constant temperature for 1.5h, adjust the pH to 8 with 1.0mol / L sodium hydroxide solution, and carry out the activation treatment of soybean protein isolate;

[0057] 2) After the activation treatment, add the lactic acid prepolymer produced by the reaction, raise the temperature to 80°C, add the catalyst after the temperature is stable, evacuate to 100Pa, and react for 4 to 12 hours to form a water-insoluble copolymer product, remove the product, and wash repeatedly , vacuum-dried to complete the graft modification of soybean protein isolate;

[0058] 3) each component and mass ratio:

[0059] Modified soybean protein: 70 parts;

[0060] Pectin and kappa carrageenan: 27 parts;

[0061] Polyethylene glycol: 1.0 parts;

[0062] Transglutaminase: 1.0 parts;

[...

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Abstract

The invention relates to a medical polymer material, in particular to a modified soybean protein hollow capsule material and a preparation method thereof, which belongs to the technical field of pharmaceutical excipients, and includes the following components and mass ratio: modified soybean protein: 60~ 85 parts; edible gum: 10-35 parts; emulsifier: 0.5-2.0 parts; Compared with traditional vegetable capsule materials, it does not contain any animal gelatin additives, and is safer and more reliable, which is unmatched by hollow capsules made of other materials. In addition, all kinds of soft and hard capsules prepared with it as pharmaceutical excipients have stable performance, low cost, no side effects, and will not affect the efficacy of drugs. They have good adaptability to traditional drug capsule equipment and do not require special Equipment modification or addition, the application potential is huge.

Description

technical field [0001] The invention relates to a medical polymer material, in particular to a modified soybean protein hollow capsule material and a preparation method thereof, and belongs to the technical field of pharmaceutical auxiliary materials. technical background [0002] Empty capsules have been developed in various varieties, such as hollow capsules, sustained-release capsules, enteric-coated soft capsules, chewable soft capsules, soft capsule suppositories, and sustained-release soft capsules. Capsules have the advantages of fast dissolution, high bioavailability, good taste masking, and easy swallowing, and are favored by patients of different ages and diseases. [0003] At present, domestic gelatin capsules are used as the main loading material for some medicines and health-care food raw materials. They play an active role in protecting the medicines and food raw materials in the capsule, realizing slow release in the body, and covering up the smell or taste of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/42
Inventor 王大威张树袁功道
Owner WUHAN INSTITUTE OF TECHNOLOGY
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