Development bone cement and its preparation method and use

A bone cement and developing technology, which is used in the field of developing bone cement and its preparation, can solve the problems of weak interaction between bone cement particles and polymer matrix, phase separation between bone cement and contrast agent, and artificial joint wear.

Active Publication Date: 2015-08-12
山东明德生物医学工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these materials can effectively play a role in imaging, these materials have a series of adverse effects on the performance of bone cement. The interaction between bone cement particles and polymer matrix is ​​weak and the bonding performance is poor, so it cannot form an effective bone cement. Overall, the phase separation of bone cement and developer is prone to occur, reducing the mechanical properties of bone cement, and causing wear and loosening of artificial joints, shortening the service life of artificial joints

Method used

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  • Development bone cement and its preparation method and use
  • Development bone cement and its preparation method and use
  • Development bone cement and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] The preparation method of above-mentioned visible bone cement, comprises the following steps:

[0024] (1) refinement treatment of the developer, the developer is ground and mixed for 0.5-5 hours, and passed through a 200-mesh sieve;

[0025] (2) Take the sieved developer and the rest of the bone cement powder in a mixer and mix for 3-12 hours;

[0026] (3) Add the mixed bone cement powder to the bone cement liquid for reconciliation. According to the mass ratio, the ratio of powder to liquid is (1.5-2.5):1.

[0027] The aforementioned visible bone cement is used for fracture fixation and bone defect filling caused by osteoporosis.

[0028] The powder polymethyl methacrylate PMMA and benzoyl peroxide are conventional ratios and options, and the liquid liquid is composed of methyl methacrylate monomer, N, N dimethyl p-toluidine and hydroquinone, It is also a conventional ratio and selection, and will not be described here.

Embodiment 1

[0029] Example 1: Using strontium phosphate as a contrast agent to prepare developable bone cement

[0030] (1) Grinding strontium phosphate for 3 hours, passing through a 200-mesh sieve on a vibrating sieve after grinding;

[0031] (2) After sieving, mix strontium phosphate with PMMA and benzoyl peroxide powder in a mixer, mix for 12 hours, and the content of benzoyl peroxide in bone cement powder mass is 0.5%;

[0032] (3) Add the mixed bone cement powder to the bone cement liquid for blending. The ratio of powder to liquid is 2:1 (mass ratio, the same below). After blending evenly, inject or fill it into the desired site.

[0033] Bone cement performance comparison is shown in Table 1, from the X-ray photo of its cured body (see figure 1 ) It can be seen that compared with the bone cement added with barium sulfate for development, when the content of strontium phosphate is 10%, there is no difference in brightness, the curing time of bone cement is 12min, and the compressi...

Embodiment 2

[0036] Example 2: Using strontium carbonate as a contrast agent to prepare developable bone cement

[0037] (1) Grinding strontium carbonate for 3 hours, after grinding, cross a 200-mesh sieve on a vibrating sieve;

[0038] (2) After sieving, strontium carbonate, PMMA, and benzoyl peroxide powder were mixed in a mixer, and mixed for 12 hours, and the content of benzoyl peroxide accounting for the bone cement powder mass was 0.5%;

[0039] (3) Add the mixed bone cement powder to the bone cement liquid for blending. The ratio of powder to liquid is 2:1. After blending evenly, inject or fill into the desired part.

[0040] Bone cement performance comparison is shown in Table 1, from the X-ray photograph of bone cement (see figure 1 ) It can be seen that compared with the bone cement added with barium sulfate for development, when the content of strontium carbonate is 10%, there is no difference in brightness, the curing time of bone cement is 14.5min, 2min longer, and the compre...

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Abstract

The invention discloses development bone cement and its preparation method and use. The development bone cement comprises powder and a liquid. The powder comprises polymethyl methacrylate (PMMA), a developer and benzoyl peroxide. The liquid comprises a methyl methacrylate (MMA) monomer as a main component. The developer is a strontium salt. The strontium salt is one of strontium phosphate, strontium sulfate and strontium carbonate. A mass ratio of the developer to the bone cement powder is in a range of 10%-30%. The development bone cement can be used for fixing of fracture caused by osteoporosis and bone defect filling.

Description

technical field [0001] The invention belongs to the field of medical materials for bone defect repair, and in particular relates to a developing bone cement and its preparation method and application. Background technique [0002] With the development of society, osteoporosis and osteoporotic fractures have become serious public health and social issues of worldwide concern. Various orthopedic diseases and bone injuries have also increased significantly. The market demand for orthopedic biomaterials is very considerable. Local treatment of osteoporosis and osteoporotic fractures is a new technique. In orthopedic surgery, percutaneous vertebroplasty (PVP) has become The minimally invasive treatment of vertebral body compression fractures caused by malignant tumors and osteoporosis mainly achieves the purpose of treatment by injecting PMMA bone cement into the vertebral body through percutaneous puncture to strengthen the vertebral body. PMMA bone cement is currently the most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/54A61L27/02
Inventor 李朝阳崔永顺邸勋吕维加
Owner 山东明德生物医学工程有限公司
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