Application of oleanolic acid in preparation of medicine for treating obesity

A technology for oleanolic acid and obesity, applied in the field of medicine, can solve the problem of unclear regulation of miR-26a expression

A technology for oleanolic acid and obesity, applied in the field of medicine, can solve the problem of unclear regulation of miR-26a expression

CN104840468AInactive Publication Date: 2015-08-19FUJIAN MEDICAL UNIV UNION HOSPITAL
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  • Application of oleanolic acid in preparation of medicine for treating obesity
  • Application of oleanolic acid in preparation of medicine for treating obesity
  • Application of oleanolic acid in preparation of medicine for treating obesity

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] The present invention will discuss the role of TGR5 as the main receptor (not the only receptor) of the natural compound OA in anti-obesity and blood sugar reduction. TGR5 can increase the expression of miR-26a in macrophages through a JNK-dependent signaling pathway, but FXR cannot. This novel association of TGR5 with miR-26a could enhance the metabolic effects of OA.

[0031] The main English abbreviations in this manual are compared with Chinese terms: BA, bile acid; CA, cholic acid; DCA, deoxycholic acid; OA, oleanolic acid; HFD, high-fat diet; GP-BAR1, G-protein bile acid-activated receptor; FXR, farnesoid receptor; T2D , type 2 diabetes; JNK, c-jun amino-terminal kinase; MAPK, mitogen-activated protein kinase; ERK1 / 2, extracellular regulated protein kinase.

[0032] Materials and Methods

[0033] Animal Feeding and Handling

[0034] C57BL / 6 and JNK1 knockout mice were purchased from Jackson Laboratory. TGR5 - / -Mice were kindly provided by Dr. Vassileva ...

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Abstract

The invention discloses an application of oleanolic acid in preparation of medicine for treating obesity. According to the invention, the oleanolic acid enables in-vitro activation of TGR5, so that mice weight is controlled and high blood sugar can be reduced, and TGR5 can adjust stable state of bile acid and energy metabolism. The experiment shows that the TGR5 as a main acceptor (not the only acceptor) of a natural compound oleanolic acid (OA) has effect for resisting obesity and reducing blood sugar. The oleanolic acid (OA) can reduce the accumulation of wild-type mice body fat, but the effect can not be embodied on TGR5 mice; the result clearly indicates that TGR5 can adjust fat-reducing effect induced by OA; the oleanolic acid (OA) has slight efficacy to TGR5, because that OA has slight activation effect to FXR or other protein.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of oleanolic acid in the preparation of medicines for treating obesity. Background technique [0002] Recent research highlights bile acid signaling molecules as new targets for the treatment of metabolic disorders, including obesity and type 2 diabetes. Two major bile acid signaling regulators have been identified: FXR and GPBAR-1 / TGR5. FXR is a transcription factor that directly regulates gene expression. In contrast, TGR5 is a bile acid membrane receptor that can initiate downstream signaling pathways to indirectly affect gene expression. TGR5 is widely expressed in different tissues but not the same. Hydrophobic bile acids, such as LCA and DCA, are potent endogenous agonists of TGR5. Functionally, TGR5 can regulate bile acid metabolism, glucose metabolism, brown adipose tissue energy metabolism and inflammation. Recently, the role of TGR5 in regulating obesity and...

Claims

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Application Information

Patent Timeline
19 Aug 2015
Publication
CN104840468A
IPC
A61K31/56; A61P3/04; A61P3/10
Inventors
陈小松; 傅湘辉