68 results about "High blood sugar level" patented technology

The embodiment of the invention provides a blood glucose monitoring and early warning method, device and equipment and a storage medium. The method comprises the following steps: acquiring historical blood glucose data and body index data of a user; determining a mean value and a standard deviation of the historical blood glucose data, and determining a blood glucose threshold value of the user based on the mean value and the standard deviation; key risk factors in the body index data and the weight corresponding to each key risk factor are determined, and the blood glucose risk score of the user is determined according to the key risk factors and the corresponding weights; and determining a blood glucose threshold value of the user and a target early warning level corresponding to the blood glucose risk score from a plurality of preset early warning levels, and executing a corresponding target early warning strategy in response to the condition that the target early warning level is greater than the preset early warning threshold value. The embodiment of the invention aims to improve the accuracy and flexibility of blood glucose monitoring and early warning.

A GLP-1 / GIP dual-targeted polypeptide, containing a first polypeptide having the following amino acid sequence: X1X2X3GT FX4SDY SX5X6X7X8 X9X10X11X12X13 X14FX15X16W LX17X18X19. The GLP-1 / GIP dual-targeted polypeptide can effectively reduce the weight and blood sugar level.

The present application relates to a blood glucose concentration analysis method, apparatus, device, storage medium, and computer program product. The method comprises: obtaining intensity sets corresponding to multiple photoplethysmographic wave sets of a target subject within a target time period; the intensity sets include average AC intensity and average DC intensity; performing curve fitting on the multiple intensity sets to obtain fitting coefficients and fitting bias; comparing the fitting bias with the bias range corresponding to the target subject, and if it is determined that the fitting bias is not within the bias range, adjusting the fitting bias to obtain an adjusted fitting bias; based on the adjusted fitting bias, performing curve fitting on the multiple intensity sets to obtain adjusted fitting coefficients, and using the adjusted fitting coefficients as the target subject's blood glucose concentration during the target time period. This method can improve the accuracy of blood glucose concentration analysis.

The present invention discloses a non-invasive blood glucose testing method based on a group big data model, which relates to the technical field of blood glucose testing, and includes the following steps: using a near-infrared spectrometer to detect spectral data in skin and tissues, and obtaining the absorption peak of glucose molecules in the near-infrared range; performing preliminary feature extraction on the obtained absorption peak, and after performing abnormal analysis on the extracted features, preliminarily judging whether the absorption peak is abnormal, and screening out the abnormal absorption peak. The present invention uses a machine learning model to screen out abnormal absorption peaks through feature extraction and abnormal analysis, ensures the use of normal data, improves the accuracy of blood glucose prediction, reduces the risk of overestimation or underestimation, provides reliable monitoring for diabetic patients, adjusts drugs in time, and reduces the risk of complications. At the same time, differential analysis and standardized deviation calculation screen out abnormal prediction values, optimize data processing, improve system robustness and final prediction accuracy, and provide accurate non-invasive blood glucose monitoring solutions.

The invention discloses a glucometer high-precision detection method based on a dynamic calibration algorithm and a glucometer, and relates to the field of blood glucose detection.The method comprises the steps that modal decomposition is conducted on a blood glucose current signal, the blood glucose current signal is decomposed into a plurality of frequency components, and an effective physiological component and an interference component are separated from the frequency components; performing time sequence feature extraction on the effective physiological component to obtain feature parameters at multiple moments, and performing correlation analysis on the feature parameters at the multiple moments, the environment temperature and the tissue impedance parameter to obtain a fusion feature vector; inputting the fusion feature vector into a parameter calibration model, and outputting a preliminary blood glucose value; a temperature correction coefficient is calculated according to the deviation between the environment temperature and the preset reference temperature, the initial blood glucose value is dynamically adjusted according to the temperature correction coefficient, and a final blood glucose detection value is obtained. By implementing the method, the detection accuracy of the glucometer can be improved.

The invention discloses an intelligent wearable product for realizing three-dimensional health monitoring management early warning and multi-dimensional first aid. An index monitoring module monitors human health related indexes in real time all day long; the risk early warning module judges the high, medium and low risk levels of each heart and cerebral vessel index and makes corresponding early warning reminding; the health conditioning module helps to regulate and improve hyperglycemia, hypertension and hyperlipidemia, and provides personalized scientific healthy diet, scientific exercise improvement suggestions and health conditioning schemes for improving emotion and sleep; the health management module generates a motion target recommendation, a sleep target recommendation, a health report and a health portrait; when it is judged that the user is in a high-risk early warning state, the emergency help seeking module automatically enters a first-aid mode, automatically dials to seek help outwards, automatically answers an incoming call, quickly positions an incident point, a nearby medical unit and an AED, and displays a pre-stored medical health electronic file, so that multi-dimensional deployment and control and defense are achieved, and the life and health of the user are protected in a three-dimensional mode.

The invention relates to a health-care product capable of reducing blood sugar. The health-care product comprises a bitter gourd extract, a cinnamon extract, a mulberry leaf extract, chromium, dietary fibers and the like. Through the multi-target effect, the product has a remarkable blood sugar reducing effect, and is suitable for diabetics and hyperglycemia people.

The present invention provides an apricot forest tea meal with effects of assisting in lowering three highs and a preparation method thereof, and relates to the field of food, the apricot forest tea meal comprises the following raw materials: a component I: 1000 parts of Chinese yam, 100 parts of jerusalem artichoke, 200 parts of radix puerariae, 10 parts of tricholoma matsutake, 50 parts of onion powder, and 10 parts of low-sugar dry yeast; component II: 2000 parts of bitter gourd, 200 parts of jerusalem artichoke, 50 parts of endothelium corneum gigeriae galli, 50 parts of lotus root, 30 parts of stevia rebaudiana, 20 parts of tricholoma matsutake and 20 parts A component III: 50 parts of Adenophora stricta, 100 parts of Jerusalem artichoke, 200 parts of hulless oat, 1000 parts of radish and 10 parts of low-sugar dry yeast; component IV: 1000 parts of asparagus, 1000 parts of okra, 1000 parts of towel gourd, 1000 parts of small bamboo shoot, 1000 parts of lotus root, 1000 parts of garlic sprout, 1000 parts of kelp, 1000 parts of banana-plant, 1000 parts of radish and 1000 parts of green Chinese onion The traditional Chinese medicine is taken as the root, diet is taken as the basis, and aiming at the characteristics of diabetes, lung, spleen and kidney deficiency, yin deficiency and internal heat, three more and one less, and the like, according to the traditional Chinese medicine dialectical diet treatment, monarch, minister, assistant and guide formula rule, the traditional Chinese medicine is aimed at lowering hyperglycemia, hypertension and hyperlipidemia.

Provided in the present application are a blood glucose monitoring method and a related apparatus. In the method, the blood glucose level at a first moment can be acquired on the basis of a glucose concentration in interstitial fluid at the first moment, a glucose concentration in the interstitial fluid within a time period before the first moment and a glucose concentration in the interstitial fluid within a time period after the first moment. In the present application, the glucose concentration in the interstitial fluid within the time period after the first moment is taken into consideration, and an additional time period is provided for the diffusion of glucose between the interstitial fluid and blood; therefore, when the blood glucose level drastically changes, the glucose concentration in the interstitial fluid more closely approximates the blood glucose level, and thus the accuracy of blood glucose monitoring can be improved.

The application discloses an AKI patient blood glucose dynamic monitoring system based on clustering processing, which comprises a data acquisition module, an initialization module, a blood glucose sample clustering processing module and a blood glucose dynamic monitoring module. The application belongs to the field of data processing and specifically refers to an AKI patient blood glucose dynamic monitoring system based on clustering processing. The scheme introduces a self-adaptive forgetting rate to construct a time decay weighted matrix, improves the sensitivity to sharp fluctuations, and avoids the response delay caused by excessive smoothing. The forgetting Mahalanobis distance fuses the time weight and the intra-cluster covariance information, reduces the noise interference, and further improves the blood glucose dynamic monitoring effect. Through non-correlation component filtering, the blood glucose is not dragged by the historical rigid components when the blood glucose suddenly drops or rises. Through elastic trust calibration, a secondary forgetting factor is introduced to exponentially attenuate the number of historical effective blood glucose samples, a stable detection factor is introduced to inhibit the small fluctuation error in the stable period, and the blood glucose mutation is quickly responded to, so that the blood glucose dynamic monitoring accuracy is improved.

The present invention relates to an edible blood sugar-improving skewer and a method for manufacturing the edible blood sugar-improving skewer. By using an eco-friendly and edible material such as cake flour, indigestible maltodextrin, salt, and water, the skewer is edible, making post-processing easy and preventing environmental pollution. It can be processed in an eco-friendly manner by dissolving it in water. Furthermore, by using indigestible maltodextrin, which can suppress blood sugar spikes, the skewer can alleviate and improve blood sugar spikes when consuming foods with high blood sugar, such as tanghulu. The invention also relates to a method for manufacturing the edible blood sugar-improving skewer.

The invention belongs to the technical field of food health, and particularly relates to a heptapeptide helpful for reducing blood sugar and application of the heptapeptide. The heptapeptide is ADTYNPR, that is, the amino acid sequence of the heptapeptide is Ala-Asp-Thr-Tyr-Asn-Pro-Arg. The heptapeptide has a DPP-IV inhibition IC50 value of 245.51 + / -13.55 g / mL, can significantly reduce a blood sugar value (Plt, 0.001) by 53.19%, can be used for preparing health food or drugs for preventing, improving or treating hyperglycemia, and has a significant effect.

The invention relates to design and application of peptidyl hydrogel, in particular to an RXD or RXDX peptide motif, a design method of the RXD or RXDX peptide motif, application of the RXD or RXDX peptide motif in preparation of medicine for treating diseases by reducing 4-GBA and the peptidyl hydrogel. In order to overcome the defects that in the prior art, osteogenesis-related growth factors cannot completely recover the osteogenesis effect in a hyperglycemia environment, or compounds such as metformin and the like can only partially reverse MSCs dysfunction, the curative effect on hyperglycemia bone regeneration deficiency is limited, or MSCs transplantation and extracellular vesicle (EVs) treatment face curative effect limitation and safety risk, the invention provides a preparation method of the osteogenesis-related growth factors. The X in the RXD or RXDX peptide motif is determined through virtual screening and affinity scoring, and finally the peptide motif with the best electrostatic adsorption effect is obtained. Meanwhile, the invention further provides application of the RXD or RXDX peptide motif and peptidyl hydrogel based on the peptide motif.

The embodiment of the invention provides a blood glucose abnormal event identification method and electronic equipment, and in the blood glucose abnormal event identification method, first electronic equipment obtains blood glucose information of a user in a first time interval from second electronic equipment; and if the blood glucose fluctuation of the second moment relative to the third moment in the first time interval is greater than or equal to the first threshold value, the first electronic equipment acquires first data, and determines that the blood glucose fluctuation is the occurrence of the blood glucose abnormal event according to the first data, so that the recognition accuracy of the blood glucose abnormal event can be improved, and the user experience is improved. And interference of events such as compression and dining can be eliminated without asking a user wearing the CGM device for a sleep time period and / or a dining time period.

The invention discloses herba cistanche and dendrobium officinale tablets and a preparation method thereof, and belongs to the field of health food manufacturing. The tablet takes 500g of cistanche, 300g of dendrobium officinale and 200g of American ginseng as main medicines, and mannitol, microcrystalline cellulose and other auxiliary materials are matched. Effective components of the medicinal materials are extracted through two times of decoction, auxiliary materials are added after concentration, tablets are prepared, and the tablets are subpackaged according to 5g per bag. The compatibility of the main medicines can regulate the balance of yin and yang, tonify kidney yang, benefit essence and blood, relax bowel, tonify stomach, promote salivation, nourish yin, clear heat and enhance immunity, and the traditional Chinese medicine composition is mild in medicine property, nourishes yin but not greasy, warms yang but not dry, and is especially suitable for middle-aged and elderly people. The preparation process guarantees the maximization of the drug effect, and the four types of auxiliary materials have a synergistic effect, so that the tablet has good formability and disintegration, is suitable for people with hyperglycemia, is convenient to take, good in taste, high in stability in storage and transportation, and sufficient in absorption of effective components, and provides a safe and efficient health maintenance product for sub-health people.

The application provides a brewing tea for yin deficiency constitution, which is composed of the following raw materials: 2-10 grams of radix puerariae, 1-15 grams of dioscorea, 1-10 grams of rhizoma phrgmitis communis, 1-10 grams of polygonatum, and 2-10 grams of lily. The application improves the synergistic effect of each component, and has better constitution conditioning effect on yin deficiency constitution, and has better auxiliary control effect on the fasting blood sugar level of yin deficiency constitution with high blood sugar.

The present application belongs to the field of biological medicine and functional food technology, and discloses a peony polypeptide microcapsule, a preparation method and application thereof in reducing blood sugar. The microcapsule is prepared by using a wrapping material to wrap the peony polypeptide for reducing blood sugar, and is made into a W1 / O / W2 type multiple emulsion, or is further dried to obtain a microcapsule solid. The present application realizes efficient encapsulation and stable release of the peony polypeptide for reducing blood sugar by using the microcapsule wrapping technology for the first time. The obtained microcapsule has uniform particle size, stable structure and good release performance. The product obtained by the technology is suitable for ordinary food, health food, special medical food and drug addition and application of high blood sugar people.

The invention provides a puffed black bean food containing active peptides and a preparation method thereof. The preparation method comprises the following steps: mixing black bean powder and siraitia grosvenorii powder in proportion, adding neutral protease and water, uniformly mixing, carrying out heat-preservation enzymolysis for 2-3 hours, carrying out high-voltage electric pulse treatment, and drying and reducing water in a drying box for 3-4 hours; and mixing the black bean powder with glutinous rice powder, puffing by a twin-screw extruder, granulating, cooling, drying and the like to obtain the puffed black bean food. The puffing degree and the brittleness of the obtained puffed black bean food are obviously improved, and the polypeptide in the food has the effects of inhibiting alpha-amylase and inhibiting nitrosation. The food can be used as a functional food for people with hyperglycemia and weight loss, and a functional food for preventing nitrosation from harming a human body. The product can be used as a puffed leisure snack food, and can also be further ground and processed into brewing meal replacement powder.

The invention discloses a personalized blood glucose prediction method and device, a medium and a product, and relates to the field of blood glucose prediction.The method comprises the steps that a historical blood glucose sequence and current blood glucose data of a to-be-detected user are obtained; the historical blood sugar sequence comprises historical blood sugar values at a plurality of sampling moments; constructing an initial blood glucose prediction model based on a long short-term memory network; in the historical blood glucose sequence, taking the historical blood glucose value at the previous sampling moment as input, taking the historical blood glucose value at the next sampling moment as output, and forming an adjustment sample pair; adjusting the initial blood glucose prediction model by adopting the adjusting sample pair until an output error of the adjusted initial blood glucose prediction model reaches a set threshold value, and taking the adjusted initial blood glucose prediction model as a final blood glucose prediction model; and inputting the current blood glucose data into the final blood glucose prediction model to obtain a blood glucose prediction result of the to-be-tested user. The method and the device can adapt to personalized requirements and improve the blood glucose prediction efficiency.

The invention relates to heterobacterium faecalis, in particular to application of heterobacterium faecalis DSM 13633 or a culture solution thereof in preparation of a medicine for preventing or treating diabetic nephropathy. The invention proves that the urine volume of a mouse with diabetic nephropathy can be reduced by the heterobacterium faecalis DSM 13633, and the levels of urinary albumin, urine creatinine and urea nitrogen can be reduced, so that the Allobacter sterilicis can be used for improving the renal function impairment induced by hyperglycemia. Meanwhile, the pathological evaluation of kidney tissue shows that the Allobaculum stericolicis can be used for improving the renal lesion of the hyperglycemia mouse. According to the present invention, with the application of the Allobaculum stericoranis, the mRNA expression level of M1 type macrophage markers (Il6, Il1beta, iNOS) in the diabetic mouse kidney tissue can be reduced, the mRNA expression level of M2 type macrophage markers (Arg1, Il10, CD206) can be increased, and the results show that the Allobaculum stericoranis can alleviate the hyperglycemia induced renal tissue inflammation state;

The invention belongs to the technical field of food processing, and particularly relates to an application of soybean phospholipid extraction by-products in food for delaying blood sugar rise, and the food is a catering beverage, staple food or snack prepared by taking the soybean phospholipid extraction by-products as one of raw materials. The staple food is steamed buns, noodles and the like, and the snacks are walnut cakes, sugar cakes and the like. According to the invention, dietary fibers contained in by-products are extracted from soybean phospholipids, food which is richer in taste and capable of effectively relieving blood sugar rise is provided for people with hyperglycemia, the soybean phospholipids are also suitable for people with weight loss to eat, the raw materials are common and easy to obtain, the processing mode is simple, the soybean fragrance is strong, and the soybean phospholipids can be accepted by most people, and the edible range is wide.

The present invention discloses a blood glucose signal processing method for blood glucose detection, which relates to the technical field of blood glucose signal processing. The method comprises: using an optical blood glucose sensor and an electrochemical blood glucose sensor to synchronously and continuously detect the blood glucose of a target user in a predicted detection window, obtaining an optical blood glucose signal detection value sequence and an electrochemical blood glucose signal detection value sequence; obtaining an optical blood glucose signal detection value subsequence set and an electrochemical blood glucose signal detection value subsequence set; performing multimodal interactive fusion analysis to obtain a blood glucose fusion feature; calling the target user's historical blood glucose feature set to authenticate the blood glucose fusion feature and obtain an authentication result. If the authentication result is passed, the blood glucose fusion feature is used as the blood glucose signal processing result. The present invention solves the technical problem in the prior art that the accuracy of blood glucose signal processing is low and it cannot effectively reflect the user's blood glucose status. The technical effect of improving the reliability of blood glucose signal processing is achieved.

Provided herein are methods of producing β cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.

Provided herein are methods of producing β cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.

The application discloses mulberry leaf composite herbal blood sugar reducing and qi regulating and liver nourishing root grass and a preparation method thereof, which is prepared from the following raw materials in parts by weight: mulberry leaves 20-35 parts, ruscus aculeatus 10-20 parts, sweet potato leaves 15-25 parts, soybeans 30-45 parts, stevia rebaudiana leaves 2-5 parts and appropriate purified water; the application can play a synergistic effect through scientific compounding of the five kinds of food and medicine homologous materials, long-term consumption can stabilize blood sugar, improve sugar tolerance, assist in regulating high blood sugar problems, help high blood sugar people better control blood sugar level, and reduce health risks caused by blood sugar fluctuation; the application has the effects of soothing liver and regulating qi, promoting blood circulation and removing blood stasis, can effectively improve symptoms such as physical fatigue, limb numbness and dark complexion caused by liver qi stagnation and incoordination of qi and blood, dredges the meridians of the whole body, promotes the running of qi and blood, and improves the metabolism level of the human body.

The invention discloses hydrogel for driving phenotypic conversion from M1 to M2 of macrophages and application of the hydrogel, the hydrogel comprises a matrix and an active component, the matrix is a chitosan quaternary ammonium salt-phenylboronic acid copolymer, and the active component is a fullerol-Apoptozole conjugate APamp formed by covalent coupling of fullerol and a small molecule inhibitor Apoptozole through an acylhydrazone bond; c60; the hydrogel is a fullerol-chitosan hydrogel which can respond to a hyperglycemia and oxidative stress wound microenvironment and can controllably release fullerol and a small molecule inhibitor Apoptozole to block a signal axis of mitochondria HSPA8-ROMO1, the three effects of antibiosis, antioxidation and immunoregulation can be integrated, and a precise treatment scheme is provided for chronic wounds of diabetes mellitus.

The invention relates to a blood glucose prediction method and device, electronic equipment and a storage medium. The method comprises the following steps: calling a feature reset parameter of a second preset time, and screening blood glucose features of a first preset time adjacent to the second preset time to obtain effective blood glucose features of the first preset time; performing fusion processing on the effective blood glucose characteristics and the blood glucose information of the second preset time to obtain fused blood glucose characteristics of the second preset time; calling a feature updating parameter of the second preset time, and performing selective updating processing on the fused blood glucose feature of the second preset time and the blood glucose feature of the first preset time to obtain an updated fused blood glucose feature of the second preset time; and performing blood glucose prediction processing based on the updated fusion blood glucose features to obtain blood glucose prediction data of third preset time adjacent to the second preset time. By adopting the method, the accuracy of blood glucose prediction can be improved.

The invention discloses multifunctional hydrogel based on delivery of CeO2 / Cu-coated Au-Pt nano-enzyme as well as a preparation method and application of the multifunctional hydrogel, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: under a water bath heating condition, sequentially adding gallic acid modified quaternized chitosan and 4-arm polyvinyl alcohol benzaldehyde into deionized water to obtain a hydrogel precursor solution; mixing the CeO2 / Cu-coated Au-Pt nano-enzyme with the hydrogel precursor solution to obtain a precursor hydrogel solution containing the nano-enzyme; and carrying out vortex treatment on the precursor hydrogel solution containing the nano-enzyme, and carrying out Schiff base crosslinking to form a QPCCAP multifunctional hydrogel network, so as to prepare the multifunctional hydrogel based on the delivery of the CeO2 / Cu-coated Au-Pt nano-enzyme. The artificial nano-enzyme hydrogel platform with multi-enzyme cascade reaction activity, developed by the invention, is helpful for solving a complex microenvironment in which hyperglycemia, high ROS and serious hypoxia of a diabetic wound surface are mutually staggered, improving wound angiogenesis and blood supply reconstruction of a diabetic patient, and is used for treating a chronic diabetic wound and accelerating wound healing.

The invention relates to the technical field of medical dressings, and discloses a diabetes wound multifunctional dressing system based on intelligent responsive hydrogel, which comprises an intelligent responsive hydrogel matrix, a biosensing module, a micro-drug storage and release module, an energy collection and wireless communication module and a central control and data processing module, all the modules cooperate to form a closed-loop intelligent treatment system. By synergistically integrating the intelligent responsive hydrogel matrix, the biosensing module, the micro-drug storage and release module and other modules, the problems that a traditional diabetes wound dressing can only achieve basic moisturizing or single treatment and cannot cope with complex dynamic changes such as wound hyperglycemia, inflammatory factor overexpression and bacterial infection are effectively solved; the functions of real-time sensing of the wound surface microenvironment, accurate delivery of multiple types of treatment drugs and the like can be completed at the same time, multi-dimensional coverage of physiological and pathological requirements of the diabetic wound surface is achieved, and the problem that the treatment effect is not comprehensive due to a single-function dressing is solved.

The invention discloses an anti-saccharification nutritional composition and application thereof, and belongs to the technical field of healthy food. The active ingredients of the anti-saccharification nutritional composition disclosed by the invention comprise HMOs and a food-grade antioxidant, breast milk oligosaccharide HMOs is taken as a main component and is combined with antioxidants such as vitamin C, vitamin E and N-acetylcysteine, so that formation of AGEs is reduced by reducing blood sugar fluctuation of a user, shortening maintenance time of a high blood sugar level and reducing inflammatory response and oxidative stress reaction, the purpose of resisting saccharification is achieved from the source, and the problems of skin yellowing and the like are remarkably improved.