A kind of Xiaoai plain tablet and preparation method thereof

A technology for Xiaoai flat tablets with average particle size, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, antineoplastic drugs, etc., and can solve the problems of poor patient compliance, poor compressibility, uneven tablet surface, Achieve the effects of easy forming and stability, smooth and beautiful surface, and stable tablet weight difference

Active Publication Date: 2019-01-11
SICHUAN GUOKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the quality of the extract prepared by the conventional method is unstable, and the compressibility after granulation is poor, so that the hardness, friability, and weight difference of the tablet are not easy to meet the standards, and the surface of the compressed tablet is uneven Uneven, affecting product quality
This product has a strong bitter taste, large dosage, long medication time, large tablet size, difficulty in swallowing, poor patient compliance, and difficult to guarantee drug efficacy

Method used

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  • A kind of Xiaoai plain tablet and preparation method thereof
  • A kind of Xiaoai plain tablet and preparation method thereof
  • A kind of Xiaoai plain tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Preparation of Xiaoai Plain Tablets of the present invention

[0021] Take 1500g of Tengguan vine, soak it in water for 12 hours, and extract it under reduced pressure for 3 times. The vacuum degree of extraction is -0.08~-0.09mpa, and the extraction temperature is controlled at 65±5°C. The extract is ultrafinely pulverized, crushed to an average particle size of 5 μm, mixed with 20 g of starch for 10 minutes, and added with a small amount of water to continue mixing for 5 minutes. Granulate with a twin-screw extruder granulator (Changzhou Huaou Drying and Granulating Equipment Co., Ltd.: SET series twin-screw extruder granulator), and press into 1000 tablets to get final product.

Embodiment 2

[0022] Embodiment 2 Preparation of Xiaoai Plain Tablets of the present invention

[0023] Take 1500g of Tengguan vine, soak it in water for 12 hours, and extract it under reduced pressure for 3 times. The extraction vacuum is -0.08~-0.09mpa; the extraction temperature is controlled at 65±5°C, the extract is ultra-micronized, crushed to an average particle size of 3 μm, mixed with 15g of starch for 10 minutes, and added with a small amount of water to continue mixing for 5 minutes. Granulate with a twin-screw extrusion granulator, press into 1000 tablets, and coat with sugar.

Embodiment 3

[0024] Embodiment 3 Preparation of Xiaoai Plain Tablets of the present invention

[0025] Take 1500g of Tengguan vine, soak it in water for 12 hours, and extract it under reduced pressure for 3 times. The extraction vacuum is -0.08~-0.09mpa; the extraction temperature is controlled at 65±5°C. The extract was ultramicronized, pulverized to an average particle size of 8 μm, mixed with 30 g of starch for 10 minutes, and added with 12.5% ​​water to continue mixing for 5 minutes. Granulate with a twin-screw extrusion granulator, press into 1000 tablets, and coat with a film.

[0026] The beneficial effect of the present invention is further illustrated by comparative experiments below.

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Abstract

The invention provides a preparation method of a Marsdenia tenacissima extract. The preparation method comprises the following steps: adding water and immersing Marsdenia tenacissima in water, carrying out vacuum extraction, carrying out ultra-fine pulverization or micronization on the extract so as to obtain the Marsdenia tenacissima extract. Vacuum extraction conditions are as follows: extraction vacuum degree is -0.08- -0.09mpa, and extraction temperature is controlled to 65+ / -5 DEG C. The invention also provides a Xiaoaiping tablet and its preparation method. By the vacuum extraction, damage to chemical components due to high normal-pressure extraction temperature is avoided, it is guaranteed that heat-sensitive components in the medicinal material are prevented from being damaged by high-temperature decoction, and precipitation of many macromolecular impurities such as starch, tannic acid, phlegm and the like also can be minimized so as to be convenient for forming and stabilization of the preparation. By compaction granulation, the problem that quality and appearance of a medicine are influenced by poor tablet friability, poor hardness, accidented surface, difficulty in coating and the like due to rough surface, large specific surface area, loose quality, low bulk density and the like of granules prepared by other granulation methods is avoided. The prepared Xiaoaiping tablet has advantages of stable medicinal composition, good anti-wettability, uniform content, stable table weight variation, high hardness, good friability and smooth and beautiful tablet surface.

Description

technical field [0001] The invention relates to a Xiaoai plain tablet, which belongs to the field of medicines. Background technique [0002] At present, the granulation methods generally adopted by traditional Chinese medicine pharmaceutical companies include wet granulation, dry granulation, spray granulation, fluidized bed granulation, etc. Among them, wet granulation includes various methods such as screw extrusion granulation, shaking granulation, high-speed stirring granulation and so on. Production Select the appropriate granulation method according to the characteristics of the required granules. As a processing process of particles, granulation can achieve the corresponding purpose required by a certain process or dosage form, and is related to the preparation and quality of almost all solid preparations. The granules produced can be final shaped products or intermediates. For example, granules, micropills, drop pills, etc. must be formed by granulation; tablets, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/27A61K9/28A61K9/36A61P35/00
Inventor 石万棋任娅莉史成刚孙晓琳刘芳
Owner SICHUAN GUOKANG PHARMA
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