Silk protein/cellulose derivative blending hydrogel and preparation method thereof

A technology of cellulose derivatives and silk protein, which is applied in the field of high-strength natural biomacromolecular hydrogel and its preparation, can solve the problem that the mechanical properties cannot reach the mechanical properties of artificially synthesized chemical hydrogels, and achieve large-scale industrial Production, low cost, simple and efficient preparation method

Inactive Publication Date: 2015-08-19
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of regenerated silk protein solutions to prepare hydrogels has been reported many times, but its mechanical properties cannot meet the mechanical properties of artificially synthesized chemical hydrogels or the requirements of tissues with high mechanical properties, such as ligaments or cartilage, etc.

Method used

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  • Silk protein/cellulose derivative blending hydrogel and preparation method thereof
  • Silk protein/cellulose derivative blending hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prepare regenerated silk protein and hydroxypropyl methylcellulose aqueous solutions with concentrations of 6%, 8% and 10%, respectively, and mix the same concentration of silk protein aqueous solution and hydroxypropyl methylcellulose aqueous solution at a volume ratio of 9:1, Ensure that the final mixed solution concentration (that is, the following solid content value) is 6%, 8% or 10%, 65 o C water bath heating 2h to form a hydrogel. The mechanical properties test shows that the tensile modulus of the hydrogel with a solid content of 6% is 0.37 MPa, the elongation at break is 120%, and the compressive modulus is 0.47 MPa; the tensile modulus of the hydrogel with a solid content of 8% is 0.75 MPa, The elongation at break was 116%, and the compressive modulus was 0.75 MPa; the tensile modulus was 1.23 MPa, the elongation at break was 108%, and the compressive modulus was 1.45 MPa.

Embodiment 2

[0026] Prepare a 10% regenerated silk protein aqueous solution and a 10% hydroxypropyl methylcellulose aqueous solution, mix the silk protein aqueous solution and the hydroxypropyl methylcellulose aqueous solution at a volume ratio of 9:1, and ensure that the final mixed solution concentration is 10%. 65 o After heating in a water bath for 2 hours, a cylindrical sample was finally obtained. The tensile modulus was 1.40 MPa, the elongation at break was 105%, and the compressive modulus was 1.34 MPa.

Embodiment 3

[0028] Prepare a 10% regenerated silk protein aqueous solution and a 10% hydroxypropyl methylcellulose aqueous solution, mix the silk protein aqueous solution and the hydroxypropyl methylcellulose aqueous solution at a volume ratio of 9:1, and ensure that the final mixed solution concentration is 10%. 90 o After heating in a water bath for 2 hours, a cylindrical sample was finally obtained. The tensile modulus was 1.28 MPa, the elongation at break was 117%, and the compressive modulus was 1.34 MPa.

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Abstract

The invention belongs to the technical field of natural polymer materials and biomedical materials, and particularly relates to a silk protein/cellulose derivative blending hydrogel and a preparation method thereof. A silk protein water solution and a blending water solution of hydroxypropyl methyl cellulose or methylcellulose or hydroxypropyl cellulose are heated to prepare the high strength hydrogel with the solid content of 4-20%. The preparation process is simple, green and mild, energy-saving and efficient and low in cost, and the physical properties of the final hydrogel can be controlled by simply changing the solid content; the prepared high strength hydrogel based on natural polymers can be applied to the field of biomedicine.

Description

technical field [0001] The invention belongs to the technical field of natural polymer materials and biomedical materials, and in particular relates to a high-strength natural biomacromolecule hydrogel and a preparation method thereof. Background technique [0002] Polymer hydrogel is a three-dimensional network with a water content of up to 90%, in which the polymer is in a swollen but insoluble state in water. Generally, hydrogels are divided into two types: chemically crosslinked hydrogels and physically crosslinked hydrogels. The advantage of ordinary chemically cross-linked hydrogels is that the mechanical properties of the final hydrogel can be controlled by changing the chemical structure, but the disadvantages are poor biocompatibility and the need to introduce chemical cross-linking agents. The advantage of physically cross-linked hydrogels is that they are often three-dimensional networks formed by natural polymers or FDA-approved synthetic polymers such as PVA, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08L1/28
Inventor 邵正中罗坤原杨宇红
Owner FUDAN UNIV
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