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Cordate houttuynia wall-breaking decoction pieces fingerprinting construction and quality detection method thereof

A technology of broken-walled decoction pieces and fingerprints, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of incomplete reflection of the quality of decoction pieces, specificity, stability, reproducibility, and poor precision, and achieve simple operation , Detection of fast and accurate results

Inactive Publication Date: 2015-08-19
ZHONGSHAN ZHONGZHI PHARMA GRP
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Problems solved by technology

Although there are detection methods involving the fingerprints of traditional Chinese medicines in the prior art, there is no method for broken-walled decoction pieces of traditional Chinese medicines with special morphology, and there are defects in specificity, stability, reproducibility and precision, which cannot fully reflect the decoction pieces. defect in quality

Method used

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  • Cordate houttuynia wall-breaking decoction pieces fingerprinting construction and quality detection method thereof
  • Cordate houttuynia wall-breaking decoction pieces fingerprinting construction and quality detection method thereof
  • Cordate houttuynia wall-breaking decoction pieces fingerprinting construction and quality detection method thereof

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Embodiment Construction

[0020] 1 Instrument and sample

[0021] 1.1 Instruments: Electric heating heavy distilled water device (Shanghai Sanshen Medical Equipment Co., Ltd.), electric heating constant temperature water bath HWS24 (Shanghai Yiheng Technology Co., Ltd., FEJ-200 electronic scale (d=0.1g), one ten thousandth electronic balance AB204- S (METTLERTOLEOD), 1 / 100,000 electronic balance AUW220D (Shimadzu Corporation) Agilent 1200RLC fast liquid chromatograph (equipped with G1315C model DAD detector, G4218A ELSD evaporative light detector, G1312B binary pump, G1329B automatic inlet Sampler, G1322A Degasser G1316B Column Thermostat, Agilent Chemstation Chromatography Workstation, Agilent ZORBAX-C18 5μm (250mm×4.6mm), Agilent ZORBAX-C18 1.8μm (50mm×4.6mm), Phenomenex Synergi 4u Fusion-RP 80A (250mm×4.6mm) chromatographic column, KQ-400KOE high-power numerical control ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.).

[0022] 1.2 Reagents: acetonitrile (chromatographically pure, Anhui...

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Abstract

The invention relates to a cordate houttuynia wall-breaking decoction pieces fingerprinting construction and a quality detection method thereof. The method takes quercitrin as a contrast, when column temperature is 30 DEG C, wavelength is 326nm, acetonitrile is a mobile phase A, 0.1% of phosphoric acid solution is a mobile phase B, gradient elution is 0-45 minutes, the mobile phase A is changed from 10%-27%, the samples with more than 10 batches are performed with an HPLC analysis, and a common mode standard atlas and determine index can be established. The quality of the samples to be detected can be detected by comparing the atlas of the sample to be detected under same chromatogram condition. The invention firstly aims at the cordate houttuynia wall-breaking decoction pieces to establish the HPLC common mode standard atlas and quality detection method. The atlas comprehensively covers the atlas information of the main active component of the cordate houttuynia wall-breaking decoction pieces, has the advantages of strong specialization, and rapid and accurate detection; and can effectively control the integral quality of medicinal material, wall breaking powder and the wall breaking decoction pieces.

Description

technical field [0001] The invention relates to a quality detection method of Chinese medicine decoction pieces, in particular to the construction of HPLC standard fingerprint spectrum of Houttuynia cordata decoction pieces and its quality detection method. Background technique [0002] Houttuynia Cordata Houttuynia cordata Thunb. is the fresh whole herb or dry aerial part of the plant Houttuynia cordata Thunb. The active ingredients are mainly volatile oil, flavonoids and phenylpropanoids. The functional components in the volatile oil are aldehyde and ketone compounds, mainly decanoyl acetaldehyde and lauric aldehyde, both of which have the specific smell of Houttuynia cordata. The main flavonoids are quercetin, quercetin, isoquercetin, hyperoside, afuside, renoside and rutin. At present, there are many studies on the quality control of Houttuynia cordata. The main research methods are as follows: 1. Control the quality standard with volatile oil or total flavonoids as th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 彭丽华王慧玲徐吉银成金乐
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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