Dual-mode coaxial in-vivo imaging method and dual-mode coaxial in-vivo imaging system

Abstract

The invention belongs to the technical field of in-vivo imaging detection and scientific instruments and discloses a dual-mode coaxial in-vivo imaging method and a dual-mode coaxial in-vivo imaging system. The system comprises an X-ray and optical signal dual-mode imaging detector, a color filter switching device, an optical imaging module, a rotary object stage, an X-ray source, more than one light source, a movement controller, a light source switching controller, a signal acquisition and digitization processor and a microprocessor. The microprocessor is connected with the movement controller, the light source switching controller and the signal acquisition and digitization processor. The X-ray and optical signal dual-mode imaging detector comprises a photoelectric conversion imaging device, an optical fiber taper, a light-permeable X-ray fluorescent conversion fiber faceplate and a detector shell. Compared with other international dual-mode or multimode in-vivo imaging detection instruments for small animals, the dual-mode coaxial in-vivo imaging system has the advantages that dual-mode coaxial parallel real-time imaging is realized, rotating registration in image fusion and reconstruction is avoided, and structural simplicity and compactness, low cost and promising application prospect are realized.

Description

technical field [0001] The invention belongs to the field of in-body imaging detection technology and scientific instruments, in particular to a dual-mode coaxial or coaxial in-body imaging technology and system structure design. Background technique [0002] In vivo molecular imaging detection of small animals is a key link in the research of medical systems biology, and it is also an intermediate bridge link for the transformation of scientific research and exploration from in vitro detection of gene protein molecules and cell levels to in vivo clinical detection applications. Among them, the multimodal imaging system based on X-ray, CT, PET and optical fluorescence molecular tomography (FMT) has been widely used in animal experiment research, and the existing multimodal imaging can be fused through computer image processing to obtain biological Information on anatomical structures, physiological functions, and biological activities at the molecular or cellular level. [...

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Problems solved by technology

The second is the detector, which is the core component of in vivo imaging of small animals. It is expensive, ranging from hundreds of thousands to millions of yuan per unit, and different imaging modalities require different types of detectors. For example, low-temperature refrigeration is used for optical imaging. CCD detectors, X-ray imaging and CT use flat panel detectors, PET uses crystal-converted high-energy ray detectors, MRI uses magnetic coils, etc. There is no detector that is compatible wit

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