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A kind of preparation method of calcined bone for surgical implant

A technology for surgical implantation and calcined bone, which is applied in the field of preparation of calcined bone for surgical implant, which can solve the problems of difficult material degradation, lack, high calcining temperature, etc., and achieve the effect of smooth transplantation process, increased nutrition, and mild treatment

Active Publication Date: 2018-03-16
FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current calcination of heterogeneous bone has the following problems: the bone often contains small mineral plaques or inorganic stains, which cannot be removed by traditional cooking and washing pretreatment methods; Long, the calcination temperature is high, the material is difficult to degrade, and the bone is deformed and deformed, which is not conducive to the operation of surgical transplantation; the lack of air supplement in the furnace, the oxidation of organic matter is not complete
In the process of bone grafting, due to unclean removal of stains, or lack of necessary nutrition, it cannot be effectively supplemented, and the graft fails or the effect is not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for preparing calcined bone for surgical implantation is carried out according to the following steps:

[0021] (1) Select heterogeneous bone or allogeneic bone as the raw material, wash the bone body with running water, and boil it in boiling water for 1 hour;

[0022] (2) Soak the boiled bone in 0.3M ammonium hydrogen phosphate solution for 12 hours, and rinse twice with 1% sodium carbonate solution;

[0023] (3) Put the soaked bone into a high-temperature furnace for calcination, calcine at 600°C for 1 hour, turn off the flame and cool down to 150°C, raise the temperature to 760°C, calcinate for 1 hour, turn off the flame and cool down to 150°C, then raise the temperature to 600°C, Turn off the flame and cool down to normal temperature; ventilate during the calcination process to help complete oxidation;

[0024] (4) Soak the calcined bone in polylysine solution for 10 hours, add adenine and basic fibroblast growth factor during the soaking process; the amo...

Embodiment 2

[0029] A method for preparing calcined bone for surgical implantation is carried out according to the following steps:

[0030] (1) Select heterogeneous bone or allogeneic bone as the raw material, wash the bone body with running water, and boil it in boiling water for 2 hours;

[0031] (2) Soak the boiled bone in 0.2M ammonium dihydrogen phosphate solution for 15 hours, and rinse it with 0.2% anilinoimidazoline solution for 3 times;

[0032] (3) Put the soaked bone into a high-temperature furnace for calcination, calcine at 700°C for 2 hours, turn off the flame and cool down to 180°C, raise the temperature to 770°C, calcinate for 2 hours, turn off the flame and cool down to 180°C, and then raise the temperature to 700°C, Turn off the flame and cool down to normal temperature; ventilate during the calcination process to help complete oxidation;

[0033] (4) Soak the calcined bone in essential amino acids for 15 hours, add adenine and basic fibroblast growth factor during the ...

Embodiment 3

[0038] A method for preparing calcined bone for surgical implantation is carried out according to the following steps:

[0039] (1) Select heterogeneous bone or allogeneic bone as the raw material, wash the bone body with running water, and boil it in boiling water for 2 hours;

[0040] (2) Soak the boiled bone in 0.2M ammonium dihydrogen phosphate solution for 16 hours, and rinse it with 1.7% sodium carbonate solution for 4 times;

[0041] (3) Put the soaked bone into a high-temperature furnace for calcination, calcine at 700°C for 2 hours, turn off the flame and cool down to 180°C, raise the temperature to 790°C, calcinate for 2 hours, turn off the flame and cool down to 180°C, and raise the temperature to 650°C, Turn off the flame and cool down to normal temperature; ventilate during the calcination process to help complete oxidation;

[0042] (4) Soak the calcined bone in the essential amino acid nutrient solution for 18 hours, add adenine and basic fibroblast growth fact...

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Abstract

The invention discloses a method for preparing calcined bone for surgical implantation, which belongs to the technical field of medical bone materials. The method uses xenograft bone or allograft bone as the initial material, soaks in weakly acidic solution, weakly alkaline solution, heats up first and then cools down, nutrient solution soaks and soluble collagen solution soaks, and is suitable for surgery. Bone material for transplantation. The method of the present invention adopts weak acidic and weak alkaline solutions to soak and wash alternately for pretreatment, the treatment is mild, and can effectively remove small mineral plaques or inorganic stains. After calcination, nutrient solution and soluble collagen solution are used to protect the bone and increase nutrition, making the transplantation process smoother.

Description

technical field [0001] The invention belongs to the technical field of medical bone materials, and in particular relates to a method for preparing calcined bone for surgical implantation. Background technique [0002] The source of xenogeneic bone material is not restricted, however the risk of infectious diseases and immune reactions is higher. Using the calcination process, under a suitable temperature curve, the organic protein components of the heterogeneous bone are completely removed, so that the regeneration of the bone can be ideally fused with the scaffold material, eliminating the risk of infectious diseases and immune reactions, and obtaining natural bone with a certain mechanical strength. Porous bioapatite scaffold material comes from a wide range of sources. [0003] The current calcination of heterogeneous bone has the following problems: the bone often contains small mineral plaques or inorganic stains, which cannot be removed by traditional cooking and wash...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/54
Inventor 赵彦涛朱加亮衷鸿宾侯树勋韩丽伟白玉龙
Owner FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA