Niclosamide ethanolamine slow-release water dispersion granules and preparation process thereof

Abstract

The invention discloses niclosamide ethanolamine slow-release water dispersion granules and a preparation process thereof. Raw materials comprise the following components in percentage by mass: 20-60 percent of niclosamide ethanolamine, 0.1-0.25 percent of polyvinyl alcohol, 1-10 percent of a dispersing agent, 4-10 percent of sodium tripolyphosphate and the balance of padding. The surfaces of the water dispersion granules are sprayed with polyvinyl alcohol protecting films, the completeness of the granules can be kept before the granules are immersed by water, and effective components are protected from being lost; after coming into contact with the water, a medicine is automatically disintegrated in the water and is uniformly dispersed in the water without the limitation of medicine application time, the medicine can be flexibly applied, the operation is convenient, playing of the medicine effect is ensured, the snail control effect is improved, and the aim of comprehensive prevention is achieved; the granules are smooth in surface and dust-free, the medicine application is environment-friendly, the medicine can be applied manually or can be applied by an unmanned aerial vehicle; compared with conventional granules, the niclosamide ethanolamine slow-release water dispersion granules have the advantages of low dosage, high efficiency and environmental friendliness.

Description

technical field

[0001] The invention belongs to the technical field of molluscicide, and in particular relates to a slow-release water-dispersible granule of spirochetamine ethanolamine salt and a preparation process thereof. Background technique

[0002] Spirocidal is the only molluscicide recommended by the World Health Organization and widely used in my country. At present, because the spiroxaden granule does not need to be diluted with water, this drug dosage form is generally used in tidal flat areas. Compared with other dosage forms, it is more convenient to operate and saves labor. However, the common granules show the following defects in the process of use: (1) Before the water surface is inflated or the snails are not flooded, the common granules have no protective film on the surface, and when they are in the humid air or the ground, most The active ingredient of the drug has been lost, which affects the molluscicidal effect of the drug; therefore, it puts forwar...

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