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Niclosamide ethanolamine slow-release water dispersion granules and preparation process thereof

The technology of spirulina ethanolamine salt and dispersing particles is applied in the directions of biocides, molluscicides, biocides, etc., and can solve the problems such as the inability of effective ingredients to diffuse evenly with water, the inability to obtain comprehensive prevention and control, and the loss of effective ingredients of medicines. To achieve the effect of ensuring the efficacy of the drug, improving the effect of snail control, and flexible application

Inactive Publication Date: 2015-09-09
JIANGSU ESSENCE AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the common granules show the following defects in the process of use: (1) Before the water surface is inflated or the snails are not flooded, the common granules have no protective film on the surface, and when they are in the humid air or the ground, most The active ingredients of the drug have been lost, which will affect the molluscicidal effect of the drug; therefore, it puts forward higher requirements for the timing of drug application
(2) Ordinary granules do not have the effect of disintegrating and dispersing in water, so the active ingredients cannot be uniformly diffused with water, and the effect of oncomelania control is not good, and comprehensive control cannot be achieved

Method used

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  • Niclosamide ethanolamine slow-release water dispersion granules and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of 30% spiroxamine ethanolamine salt slow-release water-dispersible granules

[0024] a. Take by weight 30% of the raw material spiroxamine ethanolamine salt, 10% of the dispersant NNO, 5% of sodium tripolyphosphate and filler kaolin, and put it into a jet mill for pulverization;

[0025] b. The pulverized material is kneaded with 13% water, and then granulated by rotary extrusion;

[0026] c. Weigh 0.2% polyvinyl alcohol and prepare it into a polyvinyl alcohol aqueous solution with a mass concentration of 5%, put the granulated granules into a boiling dryer for drying, and spray polyethylene during the drying process Alcohol aqueous solution; then dry the granules to get the finished product. During this period, the drying temperature is controlled between 50 and 65°C, and the drying time is between 20 and 35 minutes.

Embodiment 2

[0028] Preparation of 40% spiroxamine ethanolamine salt slow-release water-dispersible granules

[0029] a. Take by weight 40% of the raw material spiroxamine ethanolamine salt, 3% of dispersant D425, 5% of dispersant NNO, 5% of sodium tripolyphosphate and filler kaolin, and put it into a jet mill for pulverization;

[0030] b. The pulverized material is kneaded with 13% water, and then granulated by rotary extrusion;

[0031] c. Weigh 0.25% polyvinyl alcohol and prepare it into a polyvinyl alcohol aqueous solution with a mass concentration of 5%, put the granulated granules into a boiling dryer for drying, and spray polyethylene during the drying process Alcohol aqueous solution; then dry the granules to get the finished product. During this period, the drying temperature is controlled between 50 and 65°C, and the drying time is between 20 and 35 minutes.

Embodiment 3

[0033] Preparation of 50% spiroxamine ethanolamine salt slow-release water-dispersible granules

[0034] a. Put 50% of spiroxamine ethanolamine salt, 5% of dispersant NNO, 1% of dispersant K30, 5% of sodium tripolyphosphate and filler kaolin into the jet mill for pulverization;

[0035] b. The pulverized material is kneaded with 13% water, and then granulated by rotary extrusion;

[0036] c. Weigh 0.25% polyvinyl alcohol and prepare it into a polyvinyl alcohol aqueous solution with a mass concentration of 5%, put the granulated granules into a boiling dryer for drying, and spray polyethylene during the drying process Alcohol aqueous solution; then dry the granules to get the finished product. During this period, the drying temperature is controlled between 50 and 65°C, and the drying time is between 20 and 35 minutes.

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Abstract

The invention discloses niclosamide ethanolamine slow-release water dispersion granules and a preparation process thereof. Raw materials comprise the following components in percentage by mass: 20-60 percent of niclosamide ethanolamine, 0.1-0.25 percent of polyvinyl alcohol, 1-10 percent of a dispersing agent, 4-10 percent of sodium tripolyphosphate and the balance of padding. The surfaces of the water dispersion granules are sprayed with polyvinyl alcohol protecting films, the completeness of the granules can be kept before the granules are immersed by water, and effective components are protected from being lost; after coming into contact with the water, a medicine is automatically disintegrated in the water and is uniformly dispersed in the water without the limitation of medicine application time, the medicine can be flexibly applied, the operation is convenient, playing of the medicine effect is ensured, the snail control effect is improved, and the aim of comprehensive prevention is achieved; the granules are smooth in surface and dust-free, the medicine application is environment-friendly, the medicine can be applied manually or can be applied by an unmanned aerial vehicle; compared with conventional granules, the niclosamide ethanolamine slow-release water dispersion granules have the advantages of low dosage, high efficiency and environmental friendliness.

Description

technical field [0001] The invention belongs to the technical field of molluscicide, and in particular relates to a slow-release water-dispersible granule of spirochetamine ethanolamine salt and a preparation process thereof. Background technique [0002] Spirocidal is the only molluscicide recommended by the World Health Organization and widely used in my country. At present, because the spiroxaden granule does not need to be diluted with water, this drug dosage form is generally used in tidal flat areas. Compared with other dosage forms, it is more convenient to operate and saves labor. However, the common granules show the following defects in the process of use: (1) Before the water surface is inflated or the snails are not flooded, the common granules have no protective film on the surface, and when they are in the humid air or the ground, most The active ingredient of the drug has been lost, which affects the molluscicidal effect of the drug; therefore, it puts forwar...

Claims

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Application Information

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IPC IPC(8): A01N25/18A01N25/26A01N37/40A01P9/00
Inventor 石伟山王川戴宗行
Owner JIANGSU ESSENCE AGROCHEM
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