Externally-applied pharmaceutical composition for promoting healing of wound

A technology for topical medicine and wound healing. It is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of sepsis, high cost of Western medicine treatment, and enlarged wounds. It can inhibit the infiltration of wound inflammatory cells, Effects of promoting skin wound healing and maturation of granulation tissue

Inactive Publication Date: 2015-09-23
QINGDAO JINZHI HIGH NEW TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If it is not treated in time, pathogens and bacteria will invade, which will not only expand the wound, cause skin ulceration, and even cause infection, sepsis, and death
At present, the cost of Western medicine treatment for burns and skin diseases is relatively high, and the treatment cycle is long. In addition, it is difficult for patients with burns and skin diseases in rural areas to seek medical treatment, and scars will be left if they are not treated in time

Method used

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  • Externally-applied pharmaceutical composition for promoting healing of wound
  • Externally-applied pharmaceutical composition for promoting healing of wound
  • Externally-applied pharmaceutical composition for promoting healing of wound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of Chinese medicine dry ointment

[0013] Medicinal material formula: Luying 5.0kg, ramie leaves 3.8kg, orchid herbs 2.5kg, ebony 3.8kg, rhubarb 1.3kg.

[0014] Preparation method: Take the above-mentioned raw materials of Chinese medicinal materials in the prescribed amount, wash and remove impurities, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, add up for the first time Add 12 times the amount of medicinal materials in water, decoct for 2 hours, take the decoction, filter, add 10 times the amount of medicinal materials in water for the second time, decoct for 1.5 hours, take the two decoctions and combine, filter, and concentrate to 65°C A concentrated solution with a relative density of 1.15-1.20; add an appropriate amount of ethanol to make the volume alcohol content reach 75%, refrigerate at 0°C for 24 hours, f...

Embodiment 2

[0015] Embodiment 2: the preparation of Chinese medicine gel

[0016]

[0017] Preparation Process:

[0018] (1) Take by weighing the dry Chinese medicine plaster (5g or 10g) prepared by embodiment 1 according to the prescription, pulverize, cross a 100 mesh sieve, and set aside;

[0019] (2) Measure the 1,2-propanediol of prescription quantity, add in 500ml distilled water, stir well, then add the Chinese medicine dry ointment powder prepared in step (1), stir to dissolve;

[0020] (3) Mix carboxymethyl cellulose and glycerin, then add it to the solution obtained in step (2), stir evenly, let it swell into a gel, and then add distilled water to a sufficient amount.

Embodiment 3

[0026] Example 3: Experimental Study of Chinese Medicine Gel Promoting Wound Healing in Rats

[0027] Clean-grade Wistar rats, half male and half female, body weight 180-220g, depilated with 8% sodium sulfide on the back, washed with warm water and returned to the cage. Water was fasted the night before the operation. On the day of the operation, 10% chloral hydrate (300 mg / kg) was injected intraperitoneally for anesthesia. With the back spine of the rat as the midline, a square wound with a symmetrical area of ​​about 2.5 cm × 2.5 cm was designed. After 75% alcohol disinfection, the skin and superficial fascia were completely removed according to the design, until the superficial surface of the deep fascia was completely hemostasis. After injury, normal saline was injected intraperitoneally at 40 mL / kg body weight for resuscitation during the shock period. The postoperative wound was disinfected, fed in a single cage, and had free access to water and food. Rats were randomly...

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Abstract

The invention discloses an externally-applied pharmaceutical composition for promoting the healing of a wound. The pharmaceutical composition is prepared from active ingredients and auxiliary materials, wherein the active ingredients are prepared from the following traditional Chinese medicinal raw materials in parts by weight through water extraction and alcohol precipitation: 40 to 60 parts of sambucus chinensis, 33 to 46 parts of ramie leaves, 21 to 30 parts of common bluebeard herbs, 33 to 46 parts of dark plums, and 9 to 18 parts of rheum officinale. By using the externally-applied pharmaceutical composition for promoting the healing of the wound, the growth of a desmocyte and a newly born capillary can be promoted at the early stage of the healing of a trauma, and meanwhile, the infiltration of an inflammatory cell on the surface of the trauma can be restrained; the maturity of a granulation tissue, the formation of collagen and the proliferation of an epidermis can be promoted at the middle and later stages of the healing of the trauma, the excoriation of an old blood scab is quickened, and the effect of promoting the healing of the wound in skin is realized.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to an external pharmaceutical composition for promoting wound healing. Background technique [0002] A wound is a breakdown in the function and integrity of tissue in the body. In daily life, skin burns or scalds caused by careless actions often occur. In mild cases, pain and redness occur, and in severe cases, blisters and even exfoliation and necrosis of the epidermis, and injuries to bones. If it is not treated in time, pathogenic factors and bacteria will invade, which will not only enlarge the wound, cause skin ulceration, and even cause infection, sepsis, and death. At present, western medicine treatment of burns and skin diseases is expensive and takes a long time, and it is difficult for patients with burns and skin diseases in rural areas to seek medical treatment, and scars will be left if they are not treated in time. The re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P17/02
Inventor 不公告发明人
Owner QINGDAO JINZHI HIGH NEW TECH
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