Ibuprofen slow-release pellets and preparation method thereof

A technology of slow-release pellets and pellet cores, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low safety, high cost, and high equipment requirements, and achieve The production cycle is shortened, the requirements for production equipment are reduced, and the fluidity is good.

Inactive Publication Date: 2015-09-30
CHINA RESOURCES SANJIU MEDICAL & PHARMA
View PDF4 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to overcome the problems of high equipment requirements, strict parameter accuracy requirements, high cost, and low safety in

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ibuprofen slow-release pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1

[0029] prescription:

[0030] Name of raw materials

[0031] Preparation method:

[0032] Ingredients: Add povidone k30 and ibuprofen to the prescribed amount of water, stir and pass through a 60 mesh sieve to disperse the ibuprofen evenly to obtain an ibuprofen suspension; among them, ibuprofen, povidone k30 and water The mass ratio is 30:2:75;

[0033] Pill core application: add blank pill core to fluidized bed, fan frequency is 30Hz, turntable speed is 15Hz, pellet core is preheated for 20min, adjust spray pressure to 0.08Mp, needle valve pressure to 0.08MP, take step (1 ) The intermediate ibuprofen suspension is sprayed onto the pellet core through a spray gun under stirring, and dried to obtain ibuprofen sustained-release pellets. During the process, the material temperature in the fluidized bed is controlled to 45°C.

[0034] The ibuprofen sustained-release pellets are prepared according to the above-mentioned preparation method, and the finished product ra...

Example Embodiment

[0035] Example 2

[0036] prescription:

[0037] Name of raw materials

[0038] Preparation method:

[0039] Ingredients: Add povidone k30 and ibuprofen to the prescribed amount of water, stir and pass through a 60 mesh sieve to disperse the ibuprofen evenly to obtain an ibuprofen suspension; among them, ibuprofen, povidone k30 and water The mass ratio is 30:3:60;

[0040] Pill core application: add blank pill core to fluidized bed, fan frequency is 35Hz, turntable speed is 15Hz, pellet core is preheated for 30min, adjust spray pressure to 0.12Mp, needle valve pressure to 0.06MP, take step (1 ) The intermediate ibuprofen suspension was sprayed on the pellet core through a spray gun under stirring, and dried to obtain ibuprofen sustained-release pellets. During the process, the material temperature in the fluidized bed was controlled to 43°C.

[0041] The ibuprofen sustained-release pellets were prepared according to the above-mentioned preparation method, and the yield rate of one-...

Example Embodiment

[0042] Example 3

[0043] prescription:

[0044] Name of raw materials

[0045] Preparation method:

[0046] Ingredients: Add povidone k30 and ibuprofen to the prescribed amount of water, stir and pass through a 60 mesh sieve to disperse the ibuprofen evenly to obtain an ibuprofen suspension; among them, ibuprofen, povidone k30 and water The mass ratio is 30:2:80;

[0047] Pill core application: add blank pill core to fluidized bed, fan frequency is 33Hz, turntable speed is 15Hz, pellet core is preheated for 25min, adjust spray pressure to 0.10Mp, needle valve pressure to 0.04MP, take step (1 ) The intermediate ibuprofen suspension was sprayed on the pellet core through a spray gun under stirring, and dried to obtain ibuprofen sustained-release pellets. During the process, the material temperature in the fluidized bed was controlled to 47°C.

[0048] According to the above-mentioned preparation method, the sustained-release ibuprofen pellets were prepared, and the finished product ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses ibuprofen slow-release pellets and a preparation method thereof, which belong to the technical field of medicine preparation. The preparation method comprises the following steps: adding polyvinylpyrrolidone k30 and ibuprofen in water to prepare an ibuprofen suspension, wherein mass ratio of ibuprofen to polyvinylpyrrolidone k30 to water is 20-40: 1-5: 60-80; sprinkling the ibuprofen suspension on the pill cores through a fluidized bed medicine feeding technology, and drying to obtain the ibuprofen slow-release pellets, wherein the material temperature is controlled at 40-50 DEG C in the process. The preparation method employs the specific ibuprofen, polyvinylpyrrolidone k30 and water to prepare the ibuprofen suspension according to the mass ratio, the material temperature is controlled at 40-50 DEG C, ibuprofen fluidity is ensured, massive usage of ethanol is reduced during production, production cost is reduced, production safety is increased, and the prepared ibuprofen slow-release pellets have the advantages of uniform medicine feeding, good fluidity and good slow release effect.

Description

technical field [0001] The invention relates to an ibuprofen sustained-release pellet and a preparation method thereof, belonging to the technical field of medicine preparation. Background technique [0002] Ibuprofen is a non-selective cyclooxygenase inhibitor, which belongs to the class of arylpropionic acid non-steroidal anti-inflammatory drugs, and has anti-inflammatory, analgesic and anti-inflammatory effects. Ibuprofen was listed in the UK in 1966, and in 1983, ibuprofen became the first non-steroidal anti-inflammatory drug that could be sold over-the-counter in the UK; it was listed in the United States in 1974, and it was widely used as an over-the-counter drug in the United States in 1984. Pain and fever. In addition, ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. [0003] Pellets are spherical or quasi-spherical part...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/16A61K31/192A61K47/32A61P29/00
Inventor 张艳斌刘志刚张璐娜邵记马鹏岗孙亚洲
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap