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Ibuprofen slow-release pellets and preparation method thereof

A technology of slow-release pellets and pellet cores, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low safety, high cost, and high equipment requirements, and achieve The production cycle is shortened, the requirements for production equipment are reduced, and the fluidity is good.

Inactive Publication Date: 2015-09-30
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to overcome the problems of high equipment requirements, strict parameter accuracy requirements, high cost, and low safety in the prior art, aiming to provide a low equipment requirements, good production safety, and low energy consumption. , preparation method of ibuprofen sustained-release pellets with good stability

Method used

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  • Ibuprofen slow-release pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription:

[0030] Name of raw material

prescription dosage

ibuprofen

300g

Blank core (starch, sucrose 0.6-0.71mm)

80g

Povidone K 30

20g

water

750g

production

1000 capsules

[0031] Preparation method:

[0032] Ingredients: add povidone k30 and ibuprofen to the water of the prescribed amount, stir, pass through a 60-mesh sieve to disperse the ibuprofen evenly, and obtain a suspension of ibuprofen; wherein the mixture of ibuprofen, povidone k30 and water The mass ratio is 30:2:75;

[0033] Ball core application: add blank pellet cores into the fluidized bed, fan frequency is 30Hz, turntable speed is 15Hz, pellet cores are preheated for 20min, spray pressure is adjusted to 0.08Mp, needle valve pressure is 0.08MP, take step (1 ) in the ibuprofen suspension is sprayed onto the ball core by a spray gun under stirring, and dried to obtain the ibuprofen sustained-release pellets, and the mater...

Embodiment 2

[0036] prescription:

[0037] Name of raw material

prescription dosage

ibuprofen

300g

Blank core (microfine cellulose, 0.6-0.71mm)

80g

Povidone K 30

30g

water

600g

production

1000 capsules

[0038] Preparation method:

[0039] Ingredients: add povidone k30 and ibuprofen to the water of the prescribed amount, stir, pass through a 60-mesh sieve to disperse the ibuprofen evenly, and obtain a suspension of ibuprofen; wherein the mixture of ibuprofen, povidone k30 and water The mass ratio is 30:3:60;

[0040] Ball core application: add blank pellet cores into the fluidized bed, fan frequency is 35Hz, turntable speed is 15Hz, pellet cores are preheated for 30min, spray pressure is adjusted to 0.12Mp, needle valve pressure is 0.06MP, take step (1 ) in the ibuprofen suspension is stirred and sprayed onto the ball core by a spray gun, and dried to obtain the ibuprofen sustained-release pellets. During the ...

Embodiment 3

[0043] prescription:

[0044] Name of raw material

prescription dosage

ibuprofen

300g

Blank core (microfine cellulose, 0.6-0.71mm)

80g

Povidone K 30

20g

water

800g

production

1000 capsules

[0045] Preparation method:

[0046] Ingredients: add povidone k30 and ibuprofen to the water of the prescribed amount, stir, pass through a 60-mesh sieve to disperse the ibuprofen evenly, and obtain a suspension of ibuprofen; wherein the mixture of ibuprofen, povidone k30 and water The mass ratio is 30:2:80;

[0047] Ball core application: add the blank pellet core into the fluidized bed, the fan frequency is 33Hz, the turntable speed is 15Hz, the pellet core is preheated for 25min, the spray pressure is adjusted to 0.10Mp, the needle valve pressure is 0.04MP, take the step (1 ) in the ibuprofen suspension is stirred and sprayed onto the ball core by a spray gun, and dried to obtain the ibuprofen sustained-rel...

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Abstract

The invention discloses ibuprofen slow-release pellets and a preparation method thereof, which belong to the technical field of medicine preparation. The preparation method comprises the following steps: adding polyvinylpyrrolidone k30 and ibuprofen in water to prepare an ibuprofen suspension, wherein mass ratio of ibuprofen to polyvinylpyrrolidone k30 to water is 20-40: 1-5: 60-80; sprinkling the ibuprofen suspension on the pill cores through a fluidized bed medicine feeding technology, and drying to obtain the ibuprofen slow-release pellets, wherein the material temperature is controlled at 40-50 DEG C in the process. The preparation method employs the specific ibuprofen, polyvinylpyrrolidone k30 and water to prepare the ibuprofen suspension according to the mass ratio, the material temperature is controlled at 40-50 DEG C, ibuprofen fluidity is ensured, massive usage of ethanol is reduced during production, production cost is reduced, production safety is increased, and the prepared ibuprofen slow-release pellets have the advantages of uniform medicine feeding, good fluidity and good slow release effect.

Description

technical field [0001] The invention relates to an ibuprofen sustained-release pellet and a preparation method thereof, belonging to the technical field of medicine preparation. Background technique [0002] Ibuprofen is a non-selective cyclooxygenase inhibitor, which belongs to the class of arylpropionic acid non-steroidal anti-inflammatory drugs, and has anti-inflammatory, analgesic and anti-inflammatory effects. Ibuprofen was listed in the UK in 1966, and in 1983, ibuprofen became the first non-steroidal anti-inflammatory drug that could be sold over-the-counter in the UK; it was listed in the United States in 1974, and it was widely used as an over-the-counter drug in the United States in 1984. Pain and fever. In addition, ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. [0003] Pellets are spherical or quasi-spherical part...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/192A61K47/32A61P29/00
Inventor 张艳斌刘志刚张璐娜邵记马鹏岗孙亚洲
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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