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Composition for repairing epithelial injury of bladders and urinary tracts

A damage repair and composition technology, applied in the field of polymer materials, can solve problems such as low concentration of active ingredients, and achieve the effects of reducing the degree of inflammatory infiltration, good blood compatibility, reliable biological safety and effectiveness

Inactive Publication Date: 2015-09-30
BEIJING DATSING BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] CN201310753152.4 (publication number is CN103655601A) discloses a bladder irrigation agent composed of chitosan, hyaluronic acid and phosphate buffer, wherein the concentration of hyaluronic acid is 0.01-0.1%, and chitosan is 0.005-0.2%. However, the concentration of active ingredients used in it is relatively low

Method used

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  • Composition for repairing epithelial injury of bladders and urinary tracts
  • Composition for repairing epithelial injury of bladders and urinary tracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Compositions for Bladder and Urothelium Damage Repair

[0043] 1. Active ingredient content: hyaluronic acid 0.2%, chitosan 0.85%.

[0044] 2. Preparation method

[0045] (1) prepare the phosphate buffer containing the sodium chloride of 0.85% (w / v), the disodium hydrogen phosphate of 0.22% (w / v) and the sodium dihydrogen phosphate of 0.02% (w / v), and place In a high-pressure steam sterilizer, sterilize at 121°C and 0.11MPa for 30 minutes to obtain a sterile phosphate buffer solution for later use;

[0046] (2) dissolving hyaluronic acid in the sterile phosphate buffer solution obtained in step 1), and preparing a solution with a concentration of 0.4% (w / v) for subsequent use;

[0047] (3) dissolving chitosan in the sterile phosphate buffer solution obtained in step 1), and preparing a solution with a concentration of 1.7% (w / v), for subsequent use;

[0048] (4) Mix the solutions in steps (2) and (3) according to the volume ratio of 1:1, and stir well to m...

Embodiment 2

[0050] Example 2: Compositions for Bladder and Urothelium Damage Repair

[0051] 1. Active ingredient content: hyaluronic acid 0.01%, chitosan 8%.

[0052] 2. Preparation method

[0053] (1) prepare the phosphate buffer containing the sodium chloride of 0.85% (w / v), the disodium hydrogen phosphate of 0.22% (w / v) and the sodium dihydrogen phosphate of 0.02% (w / v), and place In a high-pressure steam sterilizer, sterilize at 121°C and 0.11MPa for 30 minutes to obtain a sterile phosphate buffer solution for later use;

[0054] (2) dissolving hyaluronic acid in the sterile phosphate buffer solution obtained in step 1), and preparing a solution with a concentration of 0.02% (w / v) for subsequent use;

[0055] (3) dissolving chitosan in the sterile phosphate buffer solution obtained in step 1), and preparing a solution with a concentration of 16% (w / v), for subsequent use;

[0056] (4) Mix the solutions in steps (2) and (3) according to the volume ratio of 1:1, and stir well to mak...

Embodiment 3

[0058] Example 3: Compositions for Bladder and Urothelium Damage Repair

[0059] 1. Active ingredient content: hyaluronic acid 2.5%, chitosan 0.01%.

[0060] 2. Preparation method

[0061] (1) prepare the phosphate buffer containing the sodium chloride of 0.85% (w / v), the disodium hydrogen phosphate of 0.22% (w / v) and the sodium dihydrogen phosphate of 0.02% (w / v), and place In a high-pressure steam sterilizer, sterilize at 121°C and 0.11MPa for 30 minutes to obtain a sterile phosphate buffer solution for later use;

[0062] (2) dissolving hyaluronic acid in the sterile phosphate buffer solution obtained in step 1), and preparing a solution with a concentration of 5% (w / v) for subsequent use;

[0063] (3) dissolving chitosan in the sterile phosphate buffer solution obtained in step 1), and preparing a solution with a concentration of 0.02% (w / v), for subsequent use;

[0064] (4) Mix the solutions in steps (2) and (3) according to the volume ratio of 1:1, and stir well to ma...

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Abstract

The invention relates to a composition for repairing epithelial injury of bladders and urinary tracts. The composition is composed of two or three components selected from a group including hyaluronic acid, chitosan and chondroitin sulphate. Clinical animal experiments show that the composition for repairing epithelial injury of bladders and urinary tracts disclosed by the invention is capable of obviously repairing epithelial injury of bladders due to protamine sulphate or cyclophosphamide, obviously reducing the bladder epithelial injury range and the injury degree and lightening the inflammatory infiltration degree.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a composition for repairing bladder and urethral epithelial damage and its clinical application range. Background technique [0002] Cystitis, an inflammation of the bladder, is one of the most common diseases of the urinary system. Cystitis is mainly divided into two types: acute and chronic. The pathogenic mechanism of chronic cystitis has not been widely recognized, which hinders the development of its treatment. The clinical manifestations of chronic cystitis are interstitial cystitis, glandular cystitis, chemical cystitis, radiation cystitis, etc. The main manifestations are urgency, frequency and chronic pelvic pain. [0003] The cause of chronic cystitis is still unclear, but many studies believe that epithelial injury is the main cause of chronic cystitis, and interstitial cystitis, chemical cystitis, radiation cystitis, etc. all show bladder mucosa damage. symptom. ...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61K31/728A61P29/00A61P13/10A61K31/722
Inventor 袁源翟晖李湘杰李次会殷瑞贤
Owner BEIJING DATSING BIO TECH
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