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A preparation method of single-hole hollow polyarabinogalactose-chitosan composite microspheres

A technology of arabinogalactose and composite microspheres, which is applied in the directions of non-active ingredients such as medical preparations, pharmaceutical formulations, and bulk transportation, can solve the problems of large residues, utilization restrictions, waste of biomass energy, etc., and achieves the preparation process. Simple, Inexpensive Effects

Inactive Publication Date: 2018-02-16
NORTHEAST FORESTRY UNIVERSITY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Xing'an larch contains resin, so its utilization is severely limited.
The processing residues of larch processing are very large in forest processing factories, resulting in a great waste of biomass energy, but the content of polyarabinogalactose is very high

Method used

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  • A preparation method of single-hole hollow polyarabinogalactose-chitosan composite microspheres
  • A preparation method of single-hole hollow polyarabinogalactose-chitosan composite microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Stir 2.8 mg of the water-soluble drug 5-Fu uracil, 10 mg of polyarabinogalactose, 1.075 g of chitosan, and 10 mL of 1 wt % acetic acid aqueous solution into a transparent mixture and vacuum degassing for 2 hours to obtain drug-loaded microsphere slurry A; Add 2.4g of compound emulsifier (the mass ratio of sodium lauryl sulfate to Tween-80 is 1:1) and 10mL of liquid paraffin and stir at high speed for 1 hour to form O / W emulsion B; Add 190mL of liquid paraffin and continue to stir for 1 hour to form O / W / O emulsion C; use glutaraldehyde to cross-link polyarabinogalactose and chitosan and set it at 40°C for 6 hours, cool and solidify and separate with a separatory funnel The crude microspheres D were obtained from the upper layer of liquid paraffin; the crude product D was dialyzed in distilled water with a dialysis membrane with a molecular weight cut-off of 8000Da; centrifuged at a speed of 4000r / min, washed with hot water for 3 times, and freeze-dried to obtain an averag...

Embodiment 2

[0018] Stir 2.8 mg of the water-soluble drug 5-Fu uracil, 10 mg of polyarabinogalactose, 1.075 g of chitosan, and 10 mL of 1 wt % acetic acid aqueous solution into a transparent mixture and vacuum degassing for 2 hours to obtain drug-loaded microsphere slurry A; Add 2.4g Tween-80 and 10mL liquid paraffin and stir at high speed for 1 hour to form O / W emulsion B; under the condition of 1000r / min high-speed turbulent flow, add 190mL liquid paraffin and continue stirring for 1 hour to form O / W / O emulsion C; Dialdehyde cross-linked polyarabinogalactose and chitosan and set it at 40°C for 6 hours. After cooling and solidifying, the upper layer of liquid paraffin was separated with a separating funnel to obtain crude microspheres D; a dialysis membrane with a molecular weight cut-off of 8000Da was used to The crude product D was dialyzed in distilled water; centrifuged at a speed of 4000r / min, washed three times with hot water, and freeze-dried to obtain single-hole hollow polyarabino...

Embodiment 3

[0020] Stir 2.8 mg of the water-soluble drug 5-Fu uracil, 10 mg of polyarabinogalactose, 1.075 g of chitosan, and 10 mL of 1 wt % acetic acid aqueous solution into a transparent mixture and vacuum degassing for 2 hours to obtain drug-loaded microsphere slurry A; Add 2.4g of polyvinyl alcohol and 10mL of liquid paraffin and stir at high speed for 1 hour to form O / W emulsion B; under the condition of 1000r / min high-speed turbulent flow, add 190mL of liquid paraffin and continue to stir for 1 hour to form O / W / O emulsion C; use glutaraldehyde Cross-link polyarabinogalactose and chitosan and set it at 40°C for 6 hours. After cooling and solidifying, use a separatory funnel to separate the upper liquid paraffin to obtain crude microspheres D; use a dialysis membrane with a molecular weight cut-off of 8000Da in distilled water The crude product D was dialyzed; centrifuged at a speed of 4000r / min, washed three times with hot water, and freeze-dried to obtain single-hole hollow polyarab...

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Abstract

The invention discloses a method for preparing single-hole hollow polyarabinogalactose-chitosan composite microspheres. The polyarabinogalactose, chitosan and water-soluble medicine are dispersed in an organic solvent containing an emulsifier or compatible with an emulsifier. O / W / O dispersion emulsion was prepared by ultra-high-speed emulsification and centrifugation technology, and glutaraldehyde was added to cross-link and solidify for 6 hours to form. After standing still, the organic solvent was separated with a separatory funnel to obtain crude microspheres; the molecular weight cut-off was 8000Da The crude product was dialyzed in distilled water with a dialysis membrane, centrifuged at a speed of 4000r / min, washed with hot water and then freeze-dried to obtain single-hole hollow polyarabinogalactose-chitosan composite microspheres. The polyarabinogalactose used in the invention is derived from larch processing residue, and the raw material price is low. The method does not require high equipment, the preparation process is simple and convenient for industrial production, and the used organic solvent can be reused. The preparation of the polyarabinogalactose-chitosan composite microsphere of the present invention is a chemical reaction; the microsphere slow-release carrier also has good biocompatibility and organ targeting, and has practical medical and medicinal value.

Description

technical field [0001] The invention relates to the preparation of a drug controlled release carrier and the application field of drug sustained release, in particular to a preparation method of a single-hole hollow polyarabinogalactose-chitosan composite microsphere and its application as a drug release carrier. technical background [0002] As early as the early 1970s, foreign countries began research and development of sustained-release preparations in the field of medicine, and it has been 40 years of development. Sustained-release preparations have gradually attracted clinical attention because of their advantages such as less frequent administration and long-lasting curative effect, less fluctuation in blood drug concentration, diversified administration routes, and less irritation and side effects. In recent years, research on sustained-release preparations has developed rapidly, and various dosage forms such as tablets, capsules, microspheres, liposomes, and nanosphe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K9/16C08J9/28C08J3/24C08L5/08C08L5/00
Inventor 马艳丽陈文龙方桂珍卢天云孙亚杰
Owner NORTHEAST FORESTRY UNIVERSITY
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