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Energy saving and low temperature extraction process of heparin sodium

A heparin sodium and process technology, applied in the field of biomedicine, can solve the problems of large coal burning pollution, incomplete enzymatic hydrolysis, short holding time, etc., and achieves the effects of saving energy, not easy to be deactivated, and saving fuel

Active Publication Date: 2018-04-24
DAYING COUNTY TIANFENG BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the traditional production process, it is necessary to first heat up to 50-55 degrees, keep warm for 2 hours, then add 3-4% sodium chloride, and heat up to 85-95 degrees, in order to solve the problem of incomplete enzymolysis due to short holding time To overcome, 520kg-580kg of coal is required to extract 1kg of fuel, so a lot of energy is consumed, and coal burning causes more pollution to the environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Pour clean water into the small intestine of the pig, and use a casing machine to squeeze out the small intestinal mucosa to the mucosa pool; wind the casing to form a casing handle, then put the casing casing into the soaking liquid for the first time soaking for 4 hours, take it out and drain it, and use the casing Special salt is used to marinate the casings, and then put the casings into the soaking solution for a second soak for 8 hours. The soaking solution for the first soaking is a saturated sodium chloride solution, and the soaking solution for the second soaking is a salinity of 15° Sodium chloride solution; when soaking for the first time and for the second time, soak 155 casings per 1000L of soaking liquid, collect the leachate for the first time for use, and collect the leachate for the second time as the casing for the next extraction Soaking liquid for the first soak; add the pig small intestinal mucosal slurry to the enzymatic hydrolysis tank, the pig sma...

Embodiment 2

[0023] Pour clean water into the small intestine of the pig, and use a casing machine to squeeze out the small intestinal mucosa to the mucosa pool; wind the casing to form a casing handle, then put the casing into the soaking liquid for the first time soaking for 4.5 hours, take it out and drain it, and use the casing Special salt is used to marinate the casings, and then put the casings into the soaking solution for a second soak for 7 hours. The soaking solution for the first soaking is a saturated sodium chloride solution, and the soaking solution for the second soaking is a salinity of 16° Sodium chloride solution; for the first soaking and second soaking, soak 160 casings in every 1000L soaking solution, collect the leachate from the first soaking for use, and collect the leachate after the second soaking as the casing for the next extraction Put the soaking solution soaked for the first time; add the pig small intestinal mucosal slurry into the enzymolysis tank, the pig ...

Embodiment 3

[0025]Pour clean water into the small intestine of the pig, and use a casing machine to squeeze out the small intestinal mucosa to the mucosa pool; wind the casing to form a casing handle, and then put the casing casing into the soaking liquid for the first time soaking for 5 hours, take it out and drain it, and use the casing Special salt is used to marinate the casings, and then put the casings into the soaking solution for a second soak for 6 hours. The soaking solution for the first soaking is a saturated sodium chloride solution, and the soaking solution for the second soaking is a salinity of 18° Sodium chloride solution; when soaking for the first time and for the second time, soak 165 pieces of casings per 1000L of soaking liquid, collect the leachate for the first time for use, and collect the leachate for the second time as the casing for the next extraction Soaking liquid for the first soak; add the pig small intestinal mucosal slurry to the enzymolysis tank, the pig...

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PUM

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Abstract

The present invention proposes an energy-saving and low-temperature extraction process of heparin sodium, which includes the following steps: preparation of intestinal mucosa, soaking of intestinal coating, enzymatic hydrolysis, adsorption, elution, precipitation and dehydration, adding 2709 protease to pig small intestinal mucosa, and raising the temperature to 50 -55 degrees, keep warm for 8-12 hours, add 3-4% sodium chloride, heat up to 60-65 degrees, keep warm for 1 hour, filter; the filtrate strengthens the adsorption of alkaline ion exchange resin for 8 hours, filter out the resin and add 20 % sodium chloride solution was eluted twice, and the eluent was precipitated with ethanol for 12 hours, and the ethanol was filtered to obtain crude heparin sodium. Compared with the prior art, the extraction of crude heparin sodium per kilogram can save about 200kg of coal and 30%-40% of fuel cost.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an energy-saving and low-temperature extraction process of heparin sodium. Background technique [0002] Heparin is a mucopolysaccharide that widely exists in mammalian tissues, mainly exists in mast cells, has anticoagulant effect, and is widely used in the treatment of surgery, cerebral thrombosis, myocardial infarction, etc. The molecular weight of heparin is about 3000-37500, and research on commercial heparin suggests that there are at least 21 molecular entities. Heparin sodium is the sodium salt of heparin. As a natural anticoagulant substance, heparin sodium has been valued by countries all over the world. It is also one of the main export drugs in my country. With the deepening of research, people found that heparin sodium not only has anticoagulant, antithrombotic and blood lipid regulation functions, but also has anti-inflammatory, anti-allergic, anti-viral, anti-cancer a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/10
Inventor 邓军肖莉
Owner DAYING COUNTY TIANFENG BIOLOGICAL PROD