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A method for preparing red luminescent guanylic acid/rare earth coordination polymer based on the principle of energy transfer

A coordination polymer and red light-emitting technology, which is applied to compounds containing elements of group 3/13 of the periodic table, organic compounds of group 3/13 without C-metal bonds, luminescent materials, etc., can solve the problem of low excitation energy levels etc. to achieve the effects of simple preparation, controllable luminous intensity and color, and avoiding complex synthesis

Inactive Publication Date: 2018-07-06
JIANGXI NORMAL UNIV
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  • Claims
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Problems solved by technology

However, since the excitation energy level of guanine is lower than that of rare earth europium ions, guanine cannot directly sensitize Eu 3+ emits red fluorescence
At present, the preparation of red light-emitting rare earth coordination polymers by directly using guanine as a bridging ligand to sensitize rare earth ions without the participation of guest molecules has not been reported.

Method used

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  • A method for preparing red luminescent guanylic acid/rare earth coordination polymer based on the principle of energy transfer
  • A method for preparing red luminescent guanylic acid/rare earth coordination polymer based on the principle of energy transfer
  • A method for preparing red luminescent guanylic acid/rare earth coordination polymer based on the principle of energy transfer

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Experimental program
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Embodiment 1

[0022] Embodiment 1: The mol ratio of Tb:Eu is the preparation of the guanine / rare earth coordination polymer of 1:1

[0023] First, dissolve PVP in N,N'-dimethylformamide (DMF) to prepare a PVP solution with a concentration of 10 mM. Then, pipette 500μL of PVP solution (10mM) into 3.9mL of HEPES buffer solution (10mM, pH=7.4), stir and mix. Then, 200 μL of Tb(NO 3 ) 3 and Eu(NO 3 ) 3 DMF solution and mix well. Under constant stirring, 200 μL of 100 mM GMP aqueous solution was added to the above mixture. After stirring in the greenhouse for 2 h, the white precipitate was collected by centrifugation. The precipitate was washed three times with ultrapure water, dried at 60°C for use or resuspended in ultrapure water for use.

Embodiment 2

[0024] The mol ratio of embodiment 2:Tb:Eu is the preparation of the guanine / rare earth coordination polymer of 1:2

[0025] First, dissolve PVP in N,N'-dimethylformamide (DMF) to prepare a PVP solution with a concentration of 10 mM. Then, pipette 500μL of PVP solution (10mM) into 3.7mL of HEPES buffer solution (10mM, pH=7.4), stir and mix. Then, 200 μL of 100 mM Tb(NO 3 ) 3 and 400 μL of 100mM Eu(NO 3 ) 3 DMF solution and mix well. Under constant stirring, 200 μL of 100 mM GMP aqueous solution was added to the above mixture. After stirring in the greenhouse for 2 h, the white precipitate was collected by centrifugation. The precipitate was washed three times with ultrapure water, dried at 60°C for use or resuspended in ultrapure water for use.

Embodiment 3

[0026] The mol ratio of embodiment 3:Tb:Eu is the preparation of the guanine / rare earth coordination polymer of 1:3

[0027] First, dissolve PVP in N,N'-dimethylformamide (DMF) to prepare a PVP solution with a concentration of 10 mM. Then, pipette 500μL of PVP solution (10mM) into 3.5mL of HEPES buffer solution (10mM, pH=7.4), stir and mix. Then, 200 μL of 100 mM Tb(NO 3 ) 3 and 600 μL of 100mM Eu(NO 3 ) 3 DMF solution and mix well. Under constant stirring, 200 μL of 100 mM GMP aqueous solution was added to the above mixture. After stirring in the greenhouse for 2 h, the white precipitate was collected by centrifugation. The precipitate was washed three times with ultrapure water, dried at 60°C for use or resuspended in ultrapure water for use.

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Abstract

The present invention proposes a method for preparing red luminescent guanylic acid / rare earth coordination polymer based on the principle of energy transfer. The coordination polymer is composed of guanine and two different rare earth ions (Tb3+ and Eu3+) through self-assembly to make. Based on the sensitization effect of guanine on Tb3+ and the energy resonance transfer effect between rare earth ions Tb3+ and Eu3+, the guanine / rare earth coordination polymer prepared by this method can emit high-intensity red fluorescence. Meanwhile, since guanine is a biological molecule, the guanine / rare earth coordination polymer has good biocompatibility. The method has the advantages of simple operation, rapid response, and environmental protection. The prepared guanine / rare earth coordination polymers have great application potential in chemical sensing, fluorescent labeling and cell imaging.

Description

technical field [0001] The invention relates to a method for preparing a rare earth luminescent coordination polymer using the principle of biomolecular sensitization and energy resonance transfer between rare earth ions, especially a preparation method for a red luminescent guanylic acid / rare earth coordination polymer. The prepared guanylic acid / Rare earth coordination polymers can be used in chemical sensing, fluorescent labeling and drug delivery, especially in cell tracking imaging, and belong to the field of rare earth luminescent materials preparation. Background technique [0002] Fluorescence analysis is favored by biomedical researchers because of its simple sample preparation, short analysis time, and high detection sensitivity. Fluorescent probes that emit red light have unique advantages in biological analysis and imaging, because they can well overcome the interference of biological background fluorescence (350-575 nm). Rare earth fluorescent probes have the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F5/00C09K11/06
CPCC07F5/003C09K11/06C09K2211/1044C09K2211/1088C09K2211/1096
Inventor 谭宏亮熊谢微李茜
Owner JIANGXI NORMAL UNIV
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