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Medicament for treating or preventing diseases related to multiplication of abnormal cells

A technology for proliferating diseases and abnormal cells, applied in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., can solve the problems of toxic and side effects, low killing rate of cancer cells, high concentration, etc., and achieve good results.

Active Publication Date: 2015-10-07
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current tumor drugs have a low killing rate on cancer cells or require a higher concentration, which brings many toxic and side effects

Method used

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  • Medicament for treating or preventing diseases related to multiplication of abnormal cells
  • Medicament for treating or preventing diseases related to multiplication of abnormal cells
  • Medicament for treating or preventing diseases related to multiplication of abnormal cells

Examples

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Embodiment 1

[0024] A medicine for treating or preventing diseases involving abnormal cell proliferation, the active ingredients include ferrocene derivatives, which have the following general structural formula:

[0025]

[0026] wherein R is hydrogen, alkyl, halogen, nitro or hydroxyl.

[0027] The disease involving abnormal cell proliferation is cancer.

[0028] For the preparation method of the ferrocene derivatives, see Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C–H bond activation. Chao Pi, Ying Li, Xiuling Cui, Hao Zhang, Yanbing Han and Yangjie Wu.Chem. Sci., 2013, 4, 2675-2679.

Embodiment 2

[0030] The structural formula of the ferrocene derivatives involved in this embodiment is:

[0031]

[0032] Preparation of the above-mentioned ferrocenyl olefin derivative solution: Dissolve the compound with a small amount of DMSO, and then use 1640 culture medium to prepare the original solution with a concentration of 1 mg / mL. Then prepare different final concentrations according to the needs of the experiment, and store them in the refrigerator at 4°C in the dark for future use.

[0033] 1. Anticancer activity detection in vitro

[0034] DLD-1, MCF-7, A549, HUVEC cells use 1640 medium, 10% fetal bovine serum, 5% CO 2 , and incubated in a 37°C cell culture incubator. Collect the logarithmic phase cells, adjust the concentration of the cell suspension, add 100uL to each well, and plate to adjust the density of the cells to be tested to 10,000 / well, and fill the edge wells with sterile PBS. 5%CO 2 , incubate at 37°C in a cell incubator until the cell monolayer covers ...

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Abstract

The invention discloses a medicament for treating or preventing diseases related to multiplication of abnormal cells. An effective component is a ferrocene olefins derivative which has the following structural general formula: FORMULA, wherein R is hydrogen, alkyl, halogen, nitryl or hydroxyl. The medicament can suppress growth of tumor cells by induction of apoptosis of the tumor cells and induction of production of active oxygen in the tumor cells through retardation of the period of the tumor cells and is good in effect.

Description

technical field [0001] The invention belongs to the technical field of chemical medicines, in particular to a medicine for treating or preventing diseases involving abnormal cell proliferation. Background technique [0002] Tumor is a common and frequently-occurring disease that endangers human health. In recent decades, some breakthroughs and progress have been made in the research of tumor, but the morbidity and mortality of tumor are still on the rise. Tumor treatment methods include surgical treatment, radiotherapy and drug treatment, among which chemotherapy is the main treatment at present. However, the current tumor drugs have a low killing rate on cancer cells or require a high concentration, which brings many toxic and side effects. Therefore, it is extremely urgent to discover new and highly effective antitumor compounds. Contents of the invention [0003] The object of the present invention is to provide a medicine for treating or preventing diseases involving...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F17/02A61K31/295A61P35/00
CPCA61K31/295C07F17/02
Inventor 崔秀灵孙爱静许瑞安
Owner HUAQIAO UNIVERSITY
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