Preparation method of organic-inorganic core sheath structure compound biological material and product

A technology of composite biomaterials and inorganic cores, applied in the field of preparation of products obtained by this method, organic-inorganic core-sheath structure composite biomaterials, can solve the problems of strong tissue erosion, complicated operation, high cost, etc., and achieve easy scale Chemical production, uniform surface coating, and good tissue compatibility

Inactive Publication Date: 2015-10-21
CHONGQING ACAD OF ANIMAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Polypropylene synthetic material is widely used clinically as a gynecological pelvic floor patch. Although the patch is effective, it has disadvantages such as poor compliance, strong tissue erosion, and high infection rate, and it is easy to cause related complications such as dyspareunia
In 2014, the preparation method of pelvic floor patch composite biomateria

Method used

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  • Preparation method of organic-inorganic core sheath structure compound biological material and product
  • Preparation method of organic-inorganic core sheath structure compound biological material and product

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Experimental program
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Effect test

Embodiment 1

[0027] The preparation method of organic-inorganic core sheath structure composite biological material specifically includes the following steps:

[0028] (1) Preparation of acellular tissue matrix

[0029] Take the fresh bladder of the pig, clean it with tap water, and then remove the surface mucosa to obtain the pig dermal tissue;

[0030] Cut the obtained pig dermal tissue into small pieces with scissors, rinse with pure water 3 times, and then soak in a disinfectant for 15 minutes, where the disinfectant is 0.1% neogermide;

[0031] The pig dermal tissue is immersed in a degreasing solution, placed at a temperature of 4℃, and magnetically stirred for 16 hours for degreasing to obtain degreasing pig dermal tissue; the degreasing solution is ethanol: isopropanol: water in a volume ratio of 7:4: 89 mixed;

[0032] The obtained defatted pig dermal tissue was repeatedly washed with ultrapure water for 5 times, and the defatted bladder tissue was immersed in a 0.5% acetic acid solution e...

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Abstract

The invention discloses a preparation method of an organic-inorganic core sheath structure compound biological material and the product. The method particularly comprises the following steps: immersing a dopamine activated polypropylene mesh piece into an acellular matrix solution, then adding an MES buffer solution dissolved with EDC and NHS, and conducting light resistant reaction to obtain the organic-inorganic core sheath structure compound biological material, wherein the acellular matrix solution is an MES buffer solution containing acellular matrix. The preparation method is simple, needs no special equipment and easy for scale production, and the prepared organic-inorganic core sheath structure compound biological material not only has the mechanical property of polypropylene material, but also has the good tissue compatibility of the acellular matrix, has no obvious inflammatory reaction after being implanted, and is expected to be developed and applied to the fields of regeneration medicine and the like.

Description

Technical field [0001] The invention belongs to the field of and materials, and specifically relates to a preparation method of an organic-inorganic core sheath structure composite biological material, and also relates to a product prepared by the method. Background technique [0002] Female pelvic organ prolapse is a common disease. The domestic incidence is about 40% and it is increasing year by year. It has become a major gynecological problem that seriously affects the health and quality of life of middle-aged and elderly women. Currently, polypropylene synthetic material is widely used clinically as a gynecological pelvic floor patch. Although the patch has a definite effect, it has the disadvantages of poor compliance, strong tissue erosion, high infection rate and other related complications. In 2014, the preparation method and product of pelvic floor patch composite biomaterial authorized by the State Intellectual Property Office (Patent No.: ZL201210153430.8) announced a...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/16
Inventor 葛良鹏刘雪芹游小燕丁玉春吴梦黄勇刘作华林保忠
Owner CHONGQING ACAD OF ANIMAL SCI
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