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Rosuvastatin calcium composition and application thereof in preparation of blood lipid and blood sugar lowering drugs

A technology of rosuvastatin and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problem of hypoglycemia without ciclopirox, and achieve the goal of reducing side effects and adverse reaction rate Effect

Active Publication Date: 2015-10-28
SHANGHAI XUDONG HAIPU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no literature report on ciclopirox lowering blood sugar, let alone the literature report on lowering blood lipid and blood sugar after it is combined with hydroxymethylglutaryl-CoA reductase inhibitors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 50 male SD rats, weighing 180-220g. After adaptive feeding for 1 week, randomly select 8 from 50 male SD rats as a normal control group, and the remaining 42 are used as a replica animal model. The method is: give high-sugar and high-fat feed (10% lard, sucrose 20%, cholesterol 2.5%, cholate 1%, conventional feed 66.5%) feeding. The normal control group was fed with normal rat diet. Eight weeks later, the model rats were fasted for 12 hours and injected intraperitoneally with a small dose of streptozotocin (STZ) 40 mg / kg, and the normal control group was only injected with the same dose of citrate buffer as a control. One week later, after the rats fasted for 12 hours, blood was taken to measure blood glucose, and the rat model was successfully replicated mainly when the fasting blood glucose was greater than 7.0mmol / L.

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PUM

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Abstract

The invention discloses a blood lipid and blood sugar lowering pharmaceutical composition and application thereof in preparation of drugs treating type 2 diabetes. The pharmaceutical composition is prepared from active ingredients and pharmaceutically available auxiliary materials. The active ingredients include: (1) rosuvastatin or other pharmaceutically acceptable salt; and (2) ciclopirox or ciclopirox olamine. Combined application of rosuvastatin calcium and ciclopirox has the effect of collaborative reduction of blood lipid and blood sugar, and the two can be prepared into a pharmaceutical composition to treat type 2 diabetes.

Description

technical field [0001] The invention relates to a cardiovascular drug, in particular to a pharmaceutical composition containing rosuvastatin calcium and its application in the preparation of a drug for lowering blood lipid and blood sugar, and belongs to the technical field of medicine. Background technique [0002] Type 2 diabetes, formerly known as adult-onset diabetes, usually occurs after the age of 35 to 40, accounting for more than 90% of diabetic patients. Type 2 diabetes is a pathological process from insulin resistance with relative insulin deficiency to insulin secretion with insulin resistance. Complex genetic diseases caused by multiple genes individually or interacting. In recent years, more and more evidences have proved that inflammation plays a crucial role in the occurrence of insulin resistance and pancreatic β-cell injury. The main causes of type 2 diabetes include obesity, physical inactivity and stress. Stress includes stress, exhaustion, mental stimu...

Claims

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Application Information

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IPC IPC(8): A61K31/505A61P3/06A61P3/10A61K31/4412
Inventor 白玲强
Owner SHANGHAI XUDONG HAIPU PHARMA
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