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2-aryl-2-oxazoline preparation method

A technology of oxazoline and aryl, applied in the chemical field, can solve the problem of high price of aminoethanol, and achieve the effects of increasing cost advantage, improving economy, and easily obtaining raw materials

Inactive Publication Date: 2015-10-28
ANYANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the price of aminoethanol used in these methods is relatively high, so a new synthetic process with lower raw material cost is needed in the synthesis of 2-aryl-2-oxazoline and its derivatives

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Add 121mg (1mmol) benzamide, 1mL 1,2-dichloroethane, 210mg (2mmol) sodium carbonate to a 20mL pressure-resistant reaction tube, seal, heat to 140°C for reaction, stir for 24 hours, after reaction, column chromatography After separation, 51 mg of the target product was obtained, and 73 mg of raw material benzamide and 1,2-dichloroethane were recovered. The yield based on converted starting material was 89%. The recovered benzamide and 1,2-dichloroethane are further utilized.

Embodiment 2

[0014] Add 135mg (1mmol) 4-methylbenzamide, 1mL 1,2-dichloroethane, 210mg (2mmol) sodium carbonate into a 20mL pressure-resistant reaction tube, seal it, heat to 140°C for reaction, stir for 24 hours, and react Afterwards, column chromatography separated to obtain 64 mg of the target product, and 73 mg of raw materials 4-methylbenzamide and 1,2-dichloroethane were recovered. The yield based on converted starting material was 87%. The recovered 4-methylbenzamide and 1,2-dichloroethane are further utilized.

Embodiment 3

[0016] Add 171mg (1mmol) 1-naphthylcarboxamide, 1mL 1,2-dichloroethane, 210mg (2mmol) sodium carbonate into a 20mL pressure-resistant reaction tube, seal it, heat it to 140°C for reaction, and stir for 24 hours. After the reaction, After column chromatography, 63 mg of the target product was obtained, and 103 mg of raw material benzamide and 1,2-dichloroethane were recovered. The yield was 80% based on converted starting material. The recovered benzamide and 1,2-dichloroethane are further utilized.

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Abstract

The invention discloses a 2-aryl-2-oxazoline preparation method and belongs to the field of chemistry. According to the method, an aryl-amide compound and 1,2-dichloroethane are reacted for synthesis, and the synthesis reaction is conducted under the alkaline condition. The low-price 1,2-dichloroethane is used for replacing high-price aminoethanol to serve as a raw material, the economical efficiency of the synthesis reaction is improved, and the cost advantage of the product is improved under the situation that the product quality is guaranteed.

Description

technical field [0001] The invention relates to a preparation method of oxazoline, in particular to a preparation method of 2-aryl-2-oxazoline, which belongs to the field of chemistry. Background technique [0002] 2-Oxazoline and its derivatives are an important class of organic compounds, and are key intermediates in the synthesis of many dyes, medicines, pesticides, coatings and new materials. It has always been a research hotspot to develop and explore new methods for preparing 2-oxazoline derivatives efficiently and cheaply. So far, the main methods for the synthesis of 2-aryl-2-oxazoline derivatives that humans have developed are aryl carboxylic acid derivatives (aryl acid, aryl nitrile, aryl carboxylate) and aryl formaldehyde And aryl carbinol etc. react with aminoethanol under different conditions, the reaction formula is as follows: [0003] [0004] These methods have good yields, and many have been widely used in laboratory and industrial synthesis. However,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D263/12C07D263/10C07D263/14
CPCC07D263/10C07D263/12C07D263/14
Inventor 李刚杨素玲王志勇吴汉夔何其戈韩晴晴马星星
Owner ANYANG NORMAL UNIV