High-stability corymbia citriodora essential oil nano lipidosome antibacterial agent and preparation method

Abstract

The invention belongs to the field of an antibacterial agent and a medicinal preparation or cosmetics, and particularly relates to a high-stability corymbia citriodora essential oil nano lipidosome antibacterial agent and a preparation method. The corymbia citriodora essential oil nano lipidosome is prepared by corymbia citriodora essential oil, soybean lecithin, cholesterol, surfactant, chitosan and gelatin. The preparation method comprises the steps: mixing the corymbia citriodora essential oil, soybean lecithin and cholesterol with organic solvent to obtain a mixture I, decompressing and steam drying the mixture I to form a smooth film, dissolving the film product by virtue of a water-phase medium and surfactant, forming an emulsion in an ultrasonic manner, uniformly stirring and homogenizing the emulsion with chitosan and gelatin solution, and centrifuging and filtering by virtue of a microporous filter membrane, to obtain lipidosome with a nano-scale particle size. The preparation process is good in reproducibility, the encapsulation efficiency of the corymbia citriodora essential oil multilayer nano lipidosome can reach up to 86.7 percent; moreover, the product is complete in shape, uniform in particle size and good in stability and antibacterial property.

Description

technical field [0001] The invention belongs to the field of antibacterial agents and pharmaceutical preparations or cosmetics, and in particular relates to a highly stable lemon eucalyptus essential oil nano liposome antibacterial agent and a preparation method. Background technique [0002] Lemon eucalyptus (scientific name: Eucalyptus citriodora , family name: Myrtaceae, genus name: Eucalyptus) native to Australia, China introduced it in the mid-1920s, and has been widely cultivated in Guangdong, Guangxi, Sichuan, Yunnan and other provinces and regions; from lemon eucalyptus The lemon eucalyptus oil extracted and purified from the leaves, the main active ingredient is citronellal. This essential oil has a pleasant fragrance and has been widely used in flavors, fragrances, soaps, cosmetics and food industries; studies have shown that lemon The volatile components in eucalyptus essential oil have inhibitory effects on phytopathogenic fungi, among which citronellal has an i...

AI Technical Summary

Problems solved by technology

[0004] Although lemon eucalyptus essential oil has good antibacterial properties, the extraction of lemon eucalyptus essential oil comes from pure natural plants without adding any artificial preservatives, so its chemical composition is extremely fragile and will be affected by natural environments such as air and sunlight. Moreover, the content of volatile substances in lemon eucalyptus essential oil is relatively high, and it is extremely volatile during use, which will reduce the utilization rate of lemon eucalyptus essential oil and cause waste of resources. Therefore, it is necessary to find effective ways to improve these problems

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