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Compositions consisting of alkylamidothiazoles and uv-filter substances

A technology of alkylamide and ultraviolet filter, which is applied in the direction of drug combination, medical preparations containing active ingredients, organic active ingredients, etc. It can solve the problems of lack of active ingredients and treatment possibility, chronicity, distress, etc.

Active Publication Date: 2015-11-11
BEIERSDORF AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In younger people, symptoms disappear again after a good night's sleep, but after a longer period of time the condition can become chronic and become very disturbing for the person involved
There is still a lack of sufficiently promising active ingredients and treatment possibilities for this skin manifestation

Method used

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  • Compositions consisting of alkylamidothiazoles and uv-filter substances
  • Compositions consisting of alkylamidothiazoles and uv-filter substances
  • Compositions consisting of alkylamidothiazoles and uv-filter substances

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0161] Method description for validity experiments

[0162] Thiazole effectiveness was determined by an enzymatic assay in which the conversion of levodopa to levodopaquinone by human tyrosinase was measured. In this method known from the literature (Winder, A.J., and Harris, H., New assays forthetyrosinehydroxylase and dopaoxidaseactivitiessoft tyrosinase. Eur.J. Analytical method). (1991), 198, 317-26), the reaction product levodopa quinone and MBTH (3-methyl-2-benzothiazolinone hydrazone) transforms into a pink substance, and the pink substance changes with time The increase was measured by absorption at 490 nm. In the table, the effectiveness data of several claimed substances are shown by way of example. This shows that the substances according to the invention are extremely effective pigmentation-inhibiting substances.

[0163]

[0164] Synthetic rules for exemplary selected alkylamidothiazoles:

[0165] 2-Bromo-2',4'-bismethoxycarbonyloxy-acetophenone:

[0166]...

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Abstract

Disclosed are active ingredient combinations consisting of alkylamidothiazoles and one or more cosmetically or dermatologically acceptable UV-filter substances.

Description

technical field [0001] The invention relates to an active ingredient combination consisting of an alkylamidothiazole and one or more cosmetically or dermatologically acceptable UV filter substances. The invention further relates to cosmetic and dermatological preparations with a content of such active ingredient combinations, and to their use for lightening human skin. Background technique [0002] The melanocytes responsible for the pigmentation of the skin are in the lowest layer of the epidermis (the basal layer), next to the basal cells as pigment-forming cells that occur in isolation or with more or less frequency depending on the skin type and exist. [0003] Melanocytes contain melanosomes as characteristic organelles in which melanin is formed. Furthermore, melanin formation is enhanced upon stimulation by UV radiation. The melanin is eventually transferred to the stratum corneum (keratinocytes) through the living cell layer of the epidermis (keratinocytes) and ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q19/02A61Q17/04A61K31/426A61K8/06
CPCA61K31/426A61K8/49A61K2800/5922A61Q5/002A61Q5/02A61Q5/12A61Q17/04A61P17/00A61K2300/00A61K2800/40A61Q19/02
Inventor 托比亚斯·曼卡特琳·舍纳路哲尔·科尔比扬·巴策尔
Owner BEIERSDORF AG
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