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Red-section Smilax ocreafa A. DC effective part and use thereof

A technology of effective parts and red soil, applied to medical preparations containing active ingredients, plant raw materials, bone diseases, etc., to achieve high safety, good effect, and high purity

Active Publication Date: 2015-11-18
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no studies and reports on the determination of the effective part of the sectioned red Smilax cocos in anti-inflammatory and other functions, the extraction process of the effective part and other applications.

Method used

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  • Red-section Smilax ocreafa A. DC effective part and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1: The effective part of cut-faced red Smilax cocos produced in Guizhou is the total flavonoid part of cut-faced red Smilax cocos produced in Guizhou, and the preparation method of the effective part comprises the following steps in sequence;

[0075] a, extraction process: take a certain amount of cut surface red Smilax smilax medicinal material coarse powder, add 10 times the amount of 70% ethanol for the first time to soak overnight, reflux extraction for 1.5h (the condensation tube has liquid droplets to drip out, and after slightly boiling start timing), filter to obtain the filtrate; add 8 times the amount of 70% ethanol for the second time, reflux extraction for 1h (the condensation tube has liquid droplets dripping out, and start timing after slight boiling), filter to obtain the filtrate; the third time Add 8 times the amount of 70% ethanol, reflux and extract for 1 hour (droplets drip out from the condenser tube, and start timing after slightly boili...

Embodiment 2

[0169] Example 2: The application of the effective part of cut-faced red Smilax smilax cocos produced in Guizhou in the preparation of medicines for treating or preventing rheumatoid arthritis.

[0170] 1. Rat paw adjuvant-induced inflammation experiment

[0171] 1. Research purpose

[0172] (1) To understand the effect of total flavonoids of Smilax smilax produced in Guizhou (cut surface red) on adjuvant by observing the degree of continuous dynamic paw swelling in the acute stage (primary) of rat paw adjuvant and the concentration change of NO in serum. Dynamic effects of acute inflammation on the paw of rats.

[0173] (2) Further investigate the optimal dose of total flavonoids from Guizhou (cut surface red) Smilax smilax on the primary phase of adjuvant arthritis in rats.

[0174] 2. Experimental animals

[0175] Male SD rats, 160-180g.

[0176] 3. Experimental grouping and administration

[0177] Divided into a blank control group, a model control group, a prednisone...

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Abstract

The invention discloses a red-section Smilax ocreafa A. DC effective part and a use thereof. A general flavone part is an effective part of red-section Smilax ocreafa A. DC. A ratio of the flavones components to general flavone part solids of the general flavone part is more than 90%. Through repeated tests, screening, comparison and summarizing, the preparation method (extraction method) of an effective part general flavone part of red-section Smilax ocreafa A. DC is determined. A test result shows that based on a peak area of a main chemical component astilbin of red-section Smilax ocreafa A. DC, astilbin content is 59.8%, based on the sum of peak areas of all flavones, flavones content is 94.2% and the general flavone part has high purity and good effects. The test result shows that the preparation method has good repeatability and good stability.

Description

technical field [0001] The invention relates to the effective part of cut-faced red Smilax smilax and its application, belonging to the field of traditional Chinese medicine technology. technical background [0002] Smilax glabra Roxb. is the dried rhizome of Smilax glabra Roxb., a plant in the family Liliaceae. Smilax glabra Roxb. is widely used. It is a traditional medicinal material with the same source of medicine and food. It has the functions of detoxification, dehumidification, and benefiting joints. Smilax tuckahoe sold in the market is white in section, but the section of Smilax tuckahoe produced in Guizhou is red, so the Miao people in Guizhou call it "red soil tuckahoe". It is a traditional medicinal material commonly used by the Miao people with the regional characteristics of Guizhou. Advantage. "Study on the Pharmacognosy of Smilax Smilax" (Journal of Guiyang College of Traditional Chinese Medicine, Volume 33, No. 3, Page 18-20, May 2011.) made a study on Smil...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/896A61P19/02A61P29/00A61K39/04
Inventor 董立莎农亨杜洪志任广聪葛向前何席呈
Owner 贵州中医药大学
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